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Isolated vitamin D deficiency is not associated with nonthyroidal illness syndrome, but with thyroid autoimmunity.

Arslan MS, Topaloglu O, Ucan B, Karakose M, Karbek B, Tutal E, Caliskan M, Ginis Z, Cakal E, Sahin M, Ozbek M, Delibasi T - ScientificWorldJournal (2015)

Bottom Line: In addition, the nonthyroidal illness syndrome status was evaluated.In addition, there was a significant weak inverse correlation between anti-TPO positivity and the 25(OH)D level and a positive correlation between the TSH level and 25(OH)D level.Only 1 thyroid function test result was compatible with NTIS among the participants with moderate vitamin D deficiency; therefore the difference was not significant.

View Article: PubMed Central - PubMed

Affiliation: Department of Endocrinology and Metabolism, Diskapi Training and Research Hospital, 06330 Ankara, Turkey.

ABSTRACT

Aim: This study aimed to compare thyroid functions, thyroid autoantibodies, and the existence of nonthyroidal illness syndrome (NTIS) according to vitamin D level.

Materials and methods: The study included age- and BMI-matched healthy volunteers with and without vitamin D deficiency. In addition, the nonthyroidal illness syndrome status was evaluated.

Results: Anti-TPO positivity was significantly more common in those with severe and moderate vitamin D deficiency, as compared to those with a normal 25(OH)D level. Furthermore, TSH levels were significantly lower in those with severe and moderate vitamin D deficiency than in those with a normal 25(OH)D level. In addition, there was a significant weak inverse correlation between anti-TPO positivity and the 25(OH)D level and a positive correlation between the TSH level and 25(OH)D level. Only 1 thyroid function test result was compatible with NTIS among the participants with moderate vitamin D deficiency; therefore the difference was not significant.

Conclusions: The prevalence of thyroid autoantibody positivity was higher in those with severe and moderate vitamin D deficiency than in those with a normal 25(OH)D level. Additional large-scale studies must be conducted to determine if vitamin D deficiency plays a causal role in the pathogenesis of Hashimoto's thyroiditis and NTIS.

No MeSH data available.


Related in: MedlinePlus

The correlation between anti-TPO and vitamin D in each group. The cut-off value for negative anti-TPO concentration is <57 IU mL−1.
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fig3: The correlation between anti-TPO and vitamin D in each group. The cut-off value for negative anti-TPO concentration is <57 IU mL−1.

Mentions: A positive correlation was observed between the 25(OH)D3 and TSH levels; the TSH level increased significantly as the 25(OH)D3 level increased (r = 0.213, P = 0.008) (Figure 1). Furthermore, a negative correlation was observed between anti-TPO and anti-Tg levels and the 25(OH)D3 level (r = −0.199 and P = 0.017 and r = −0.154 and P = 0.05, resp.) (Figures 2 and 3).


Isolated vitamin D deficiency is not associated with nonthyroidal illness syndrome, but with thyroid autoimmunity.

Arslan MS, Topaloglu O, Ucan B, Karakose M, Karbek B, Tutal E, Caliskan M, Ginis Z, Cakal E, Sahin M, Ozbek M, Delibasi T - ScientificWorldJournal (2015)

The correlation between anti-TPO and vitamin D in each group. The cut-off value for negative anti-TPO concentration is <57 IU mL−1.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4306373&req=5

fig3: The correlation between anti-TPO and vitamin D in each group. The cut-off value for negative anti-TPO concentration is <57 IU mL−1.
Mentions: A positive correlation was observed between the 25(OH)D3 and TSH levels; the TSH level increased significantly as the 25(OH)D3 level increased (r = 0.213, P = 0.008) (Figure 1). Furthermore, a negative correlation was observed between anti-TPO and anti-Tg levels and the 25(OH)D3 level (r = −0.199 and P = 0.017 and r = −0.154 and P = 0.05, resp.) (Figures 2 and 3).

Bottom Line: In addition, the nonthyroidal illness syndrome status was evaluated.In addition, there was a significant weak inverse correlation between anti-TPO positivity and the 25(OH)D level and a positive correlation between the TSH level and 25(OH)D level.Only 1 thyroid function test result was compatible with NTIS among the participants with moderate vitamin D deficiency; therefore the difference was not significant.

View Article: PubMed Central - PubMed

Affiliation: Department of Endocrinology and Metabolism, Diskapi Training and Research Hospital, 06330 Ankara, Turkey.

ABSTRACT

Aim: This study aimed to compare thyroid functions, thyroid autoantibodies, and the existence of nonthyroidal illness syndrome (NTIS) according to vitamin D level.

Materials and methods: The study included age- and BMI-matched healthy volunteers with and without vitamin D deficiency. In addition, the nonthyroidal illness syndrome status was evaluated.

Results: Anti-TPO positivity was significantly more common in those with severe and moderate vitamin D deficiency, as compared to those with a normal 25(OH)D level. Furthermore, TSH levels were significantly lower in those with severe and moderate vitamin D deficiency than in those with a normal 25(OH)D level. In addition, there was a significant weak inverse correlation between anti-TPO positivity and the 25(OH)D level and a positive correlation between the TSH level and 25(OH)D level. Only 1 thyroid function test result was compatible with NTIS among the participants with moderate vitamin D deficiency; therefore the difference was not significant.

Conclusions: The prevalence of thyroid autoantibody positivity was higher in those with severe and moderate vitamin D deficiency than in those with a normal 25(OH)D level. Additional large-scale studies must be conducted to determine if vitamin D deficiency plays a causal role in the pathogenesis of Hashimoto's thyroiditis and NTIS.

No MeSH data available.


Related in: MedlinePlus