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Association between BMP4 rs17563 polymorphism and NSCL/P risk: a meta-analysis.

Hu YY, Qin CQ, Deng MH, Niu YM, Long X - Dis. Markers (2015)

Bottom Line: Overall, no significant association between BMP4 rs17563 polymorphism and NSCL/P risk was found.It was notable that significant susceptibility on different ethnicity was observed in the stratified analysis.On the contrary, significantly protective effects were found in Brazilian population (C versus T: OR = 0.69, 95% CI = 0.50-0.96, P = 0.03, I(2) = 68.5%; TC versus TT: OR = 0.52, 95% CI = 0.40-0.68, P < 0.01, I(2) = 0%; TC + CC versus TT: OR = 0.52, 95% CI = 0.35-0.78, P < 0.010, I(2) = 54.4%).

View Article: PubMed Central - PubMed

Affiliation: Department of Oral and Maxillofacial Surgery, The State Key Laboratory Breeding Base of Basic Science of Stomatology and Key Laboratory of Oral Biomedicine, Ministry of Education, School and Hospital of Stomatology, Wuhan University, Luoyu Road 237, Wuhan 430079, China ; Department of Stomatology and Evidence-Based Medicine Center, Taihe Hospital, Hubei University of Medicine, 32 South Renmin Road, Shiyan 442000, China.

ABSTRACT

Objective: To investigate the association between bone morphogenetic protein 4 (BMP4) rs17563 polymorphism and nonsyndromic cleft lip with or without palate (NSCL/P) risk.

Methods: Four online databases were researched and the related publications were collected. Odds ratio (OR) with 95% confidence interval (CI) was applied to assess the relationship; publication bias, metaregression, and sensitivity analysis were conducted to guarantee the strength of results.

Results: Six published case-control studies were collected. Overall, no significant association between BMP4 rs17563 polymorphism and NSCL/P risk was found. It was notable that significant susceptibility on different ethnicity was observed in the stratified analysis. For Chinese population, the BMP4 rs17563 polymorphism was a significantly increased risk for NSCL/P (C versus T: OR = 1.52, 95% CI = 1.28-1.82, P < 0.01, I (2) = 0%; CC versus TT: OR = 2.58, 95% CI = 1.74-3.82, P < 0.01, I (2) = 0%; TC + CC versus TT: OR = 1.45, 95% CI = 1.14-1.84, P < 0.01, I (2) = 0%; CC versus TT + TC: OR=2.46, 95% CI = 1.46-4.14, P < 0.01, I(2) = 47.0%). On the contrary, significantly protective effects were found in Brazilian population (C versus T: OR = 0.69, 95% CI = 0.50-0.96, P = 0.03, I(2) = 68.5%; TC versus TT: OR = 0.52, 95% CI = 0.40-0.68, P < 0.01, I(2) = 0%; TC + CC versus TT: OR = 0.52, 95% CI = 0.35-0.78, P < 0.010, I(2) = 54.4%).

Conclusion: This meta-analysis indicated that BMP4 rs17563 polymorphism could play a different role during the development of NSCL/P based on ethnicity diversity.

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Related in: MedlinePlus

Flow diagram of the study selection process.
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Related In: Results  -  Collection


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fig1: Flow diagram of the study selection process.

Mentions: Thirty-three relevant studies were selected based on the search words. The flow chart of study selection is presented in Figure 1. After screening the titles and duplicated reports, 21 of the publications were excluded. Abstracts and full texts of the remaining 12 articles were reviewed, and six studies were subsequently excluded. Finally, six publications with eligible genotypes were selected. These studies included 1,040 cases and 1,260 controls [12–17] and were subjected to meta-analysis. No study deviated from HWE. Also, the minor allele frequency of the C allele ranged from 0.27 to 0.52. The characteristics of included studies are summarized in Table 1.


Association between BMP4 rs17563 polymorphism and NSCL/P risk: a meta-analysis.

Hu YY, Qin CQ, Deng MH, Niu YM, Long X - Dis. Markers (2015)

Flow diagram of the study selection process.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4306361&req=5

fig1: Flow diagram of the study selection process.
Mentions: Thirty-three relevant studies were selected based on the search words. The flow chart of study selection is presented in Figure 1. After screening the titles and duplicated reports, 21 of the publications were excluded. Abstracts and full texts of the remaining 12 articles were reviewed, and six studies were subsequently excluded. Finally, six publications with eligible genotypes were selected. These studies included 1,040 cases and 1,260 controls [12–17] and were subjected to meta-analysis. No study deviated from HWE. Also, the minor allele frequency of the C allele ranged from 0.27 to 0.52. The characteristics of included studies are summarized in Table 1.

Bottom Line: Overall, no significant association between BMP4 rs17563 polymorphism and NSCL/P risk was found.It was notable that significant susceptibility on different ethnicity was observed in the stratified analysis.On the contrary, significantly protective effects were found in Brazilian population (C versus T: OR = 0.69, 95% CI = 0.50-0.96, P = 0.03, I(2) = 68.5%; TC versus TT: OR = 0.52, 95% CI = 0.40-0.68, P < 0.01, I(2) = 0%; TC + CC versus TT: OR = 0.52, 95% CI = 0.35-0.78, P < 0.010, I(2) = 54.4%).

View Article: PubMed Central - PubMed

Affiliation: Department of Oral and Maxillofacial Surgery, The State Key Laboratory Breeding Base of Basic Science of Stomatology and Key Laboratory of Oral Biomedicine, Ministry of Education, School and Hospital of Stomatology, Wuhan University, Luoyu Road 237, Wuhan 430079, China ; Department of Stomatology and Evidence-Based Medicine Center, Taihe Hospital, Hubei University of Medicine, 32 South Renmin Road, Shiyan 442000, China.

ABSTRACT

Objective: To investigate the association between bone morphogenetic protein 4 (BMP4) rs17563 polymorphism and nonsyndromic cleft lip with or without palate (NSCL/P) risk.

Methods: Four online databases were researched and the related publications were collected. Odds ratio (OR) with 95% confidence interval (CI) was applied to assess the relationship; publication bias, metaregression, and sensitivity analysis were conducted to guarantee the strength of results.

Results: Six published case-control studies were collected. Overall, no significant association between BMP4 rs17563 polymorphism and NSCL/P risk was found. It was notable that significant susceptibility on different ethnicity was observed in the stratified analysis. For Chinese population, the BMP4 rs17563 polymorphism was a significantly increased risk for NSCL/P (C versus T: OR = 1.52, 95% CI = 1.28-1.82, P < 0.01, I (2) = 0%; CC versus TT: OR = 2.58, 95% CI = 1.74-3.82, P < 0.01, I (2) = 0%; TC + CC versus TT: OR = 1.45, 95% CI = 1.14-1.84, P < 0.01, I (2) = 0%; CC versus TT + TC: OR=2.46, 95% CI = 1.46-4.14, P < 0.01, I(2) = 47.0%). On the contrary, significantly protective effects were found in Brazilian population (C versus T: OR = 0.69, 95% CI = 0.50-0.96, P = 0.03, I(2) = 68.5%; TC versus TT: OR = 0.52, 95% CI = 0.40-0.68, P < 0.01, I(2) = 0%; TC + CC versus TT: OR = 0.52, 95% CI = 0.35-0.78, P < 0.010, I(2) = 54.4%).

Conclusion: This meta-analysis indicated that BMP4 rs17563 polymorphism could play a different role during the development of NSCL/P based on ethnicity diversity.

Show MeSH
Related in: MedlinePlus