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Artery buckling affects the mechanical stress in atherosclerotic plaques.

Sanyal A, Han HC - Biomed Eng Online (2015)

Bottom Line: Tortuous arteries are often seen in patients with hypertension and atherosclerosis.Artery with asymmetric plaque had lower critical buckling pressure compared to the artery with symmetric plaque and control artery.Stiffer calcified tissue and severe stenosis increased the critical buckling pressure of the artery with asymmetric plaque.

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ABSTRACT

Background: Tortuous arteries are often seen in patients with hypertension and atherosclerosis. While the mechanical stress in atherosclerotic plaque under lumen pressure has been studied extensively, the mechanical stability of atherosclerotic arteries and subsequent effect on the plaque stress remain unknown. To this end, we investigated the buckling and post-buckling behavior of model stenotic coronary arteries with symmetric and asymmetric plaque.

Methods: Buckling analysis for a model coronary artery with symmetric and asymmetric plaque was conducted using finite element analysis based on the dimensions and nonlinear anisotropic materials properties reported in the literature.

Results: Artery with asymmetric plaque had lower critical buckling pressure compared to the artery with symmetric plaque and control artery. Buckling increased the peak stress in the plaque and led to the development of a high stress concentration in artery with asymmetric plaque. Stiffer calcified tissue and severe stenosis increased the critical buckling pressure of the artery with asymmetric plaque.

Conclusions: Arteries with atherosclerotic plaques are prone to mechanical buckling which leads to a high stress concentration in the plaques that can possibly make the plaques prone to rupture.

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von Mises stress distribution in the artery lumen and the plaque (longitudinal-section view) for a normal artery, artery with symmetric plaque and artery with asymmetric plaque at a lumen pressure of 100 mmHg.
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Figure 5: von Mises stress distribution in the artery lumen and the plaque (longitudinal-section view) for a normal artery, artery with symmetric plaque and artery with asymmetric plaque at a lumen pressure of 100 mmHg.

Mentions: The symmetry of the plaque (symmetric or asymmetric) had a significant effect on the location and magnitude of peak stress in the plaque post-buckling (Figure 5). At a physiological lumen pressure of 100 mmHg, the maximum stress in the symmetric plaque model was observed in the calcified tissue and its magnitude was 32% higher than the maximum stress in the lumen of the normal artery (305 kPa vs 234 kPa). However, the maximum stress in the asymmetric model was observed in the fibrous cap located slightly away from the center of the artery and had almost four-fold higher magnitude (960 kPa). Also, the maximum stress in the asymmetric plaque model increased much more rapidly with increasing lumen pressure compared to the symmetric plaque model (Figure 6).


Artery buckling affects the mechanical stress in atherosclerotic plaques.

Sanyal A, Han HC - Biomed Eng Online (2015)

von Mises stress distribution in the artery lumen and the plaque (longitudinal-section view) for a normal artery, artery with symmetric plaque and artery with asymmetric plaque at a lumen pressure of 100 mmHg.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4306115&req=5

Figure 5: von Mises stress distribution in the artery lumen and the plaque (longitudinal-section view) for a normal artery, artery with symmetric plaque and artery with asymmetric plaque at a lumen pressure of 100 mmHg.
Mentions: The symmetry of the plaque (symmetric or asymmetric) had a significant effect on the location and magnitude of peak stress in the plaque post-buckling (Figure 5). At a physiological lumen pressure of 100 mmHg, the maximum stress in the symmetric plaque model was observed in the calcified tissue and its magnitude was 32% higher than the maximum stress in the lumen of the normal artery (305 kPa vs 234 kPa). However, the maximum stress in the asymmetric model was observed in the fibrous cap located slightly away from the center of the artery and had almost four-fold higher magnitude (960 kPa). Also, the maximum stress in the asymmetric plaque model increased much more rapidly with increasing lumen pressure compared to the symmetric plaque model (Figure 6).

Bottom Line: Tortuous arteries are often seen in patients with hypertension and atherosclerosis.Artery with asymmetric plaque had lower critical buckling pressure compared to the artery with symmetric plaque and control artery.Stiffer calcified tissue and severe stenosis increased the critical buckling pressure of the artery with asymmetric plaque.

View Article: PubMed Central - HTML - PubMed

ABSTRACT

Background: Tortuous arteries are often seen in patients with hypertension and atherosclerosis. While the mechanical stress in atherosclerotic plaque under lumen pressure has been studied extensively, the mechanical stability of atherosclerotic arteries and subsequent effect on the plaque stress remain unknown. To this end, we investigated the buckling and post-buckling behavior of model stenotic coronary arteries with symmetric and asymmetric plaque.

Methods: Buckling analysis for a model coronary artery with symmetric and asymmetric plaque was conducted using finite element analysis based on the dimensions and nonlinear anisotropic materials properties reported in the literature.

Results: Artery with asymmetric plaque had lower critical buckling pressure compared to the artery with symmetric plaque and control artery. Buckling increased the peak stress in the plaque and led to the development of a high stress concentration in artery with asymmetric plaque. Stiffer calcified tissue and severe stenosis increased the critical buckling pressure of the artery with asymmetric plaque.

Conclusions: Arteries with atherosclerotic plaques are prone to mechanical buckling which leads to a high stress concentration in the plaques that can possibly make the plaques prone to rupture.

Show MeSH
Related in: MedlinePlus