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Artery buckling affects the mechanical stress in atherosclerotic plaques.

Sanyal A, Han HC - Biomed Eng Online (2015)

Bottom Line: Tortuous arteries are often seen in patients with hypertension and atherosclerosis.Artery with asymmetric plaque had lower critical buckling pressure compared to the artery with symmetric plaque and control artery.Stiffer calcified tissue and severe stenosis increased the critical buckling pressure of the artery with asymmetric plaque.

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ABSTRACT

Background: Tortuous arteries are often seen in patients with hypertension and atherosclerosis. While the mechanical stress in atherosclerotic plaque under lumen pressure has been studied extensively, the mechanical stability of atherosclerotic arteries and subsequent effect on the plaque stress remain unknown. To this end, we investigated the buckling and post-buckling behavior of model stenotic coronary arteries with symmetric and asymmetric plaque.

Methods: Buckling analysis for a model coronary artery with symmetric and asymmetric plaque was conducted using finite element analysis based on the dimensions and nonlinear anisotropic materials properties reported in the literature.

Results: Artery with asymmetric plaque had lower critical buckling pressure compared to the artery with symmetric plaque and control artery. Buckling increased the peak stress in the plaque and led to the development of a high stress concentration in artery with asymmetric plaque. Stiffer calcified tissue and severe stenosis increased the critical buckling pressure of the artery with asymmetric plaque.

Conclusions: Arteries with atherosclerotic plaques are prone to mechanical buckling which leads to a high stress concentration in the plaques that can possibly make the plaques prone to rupture.

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Buckling displacement (maximum deflection at the middle) plotted as function of lumen pressure of a normal artery, artery with symmetric plaque, and artery with an asymmetric plaque.
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Figure 2: Buckling displacement (maximum deflection at the middle) plotted as function of lumen pressure of a normal artery, artery with symmetric plaque, and artery with an asymmetric plaque.

Mentions: The presence of an atherosclerotic plaque affects the critical buckling pressure of a coronary artery. The buckling behavior of the stenotic artery with plaque was different from the normal artery and different for symmetric and asymmetric plaques. The stenotic artery with a symmetric plaque had a critical buckling pressure (7.0 kPa) close to that of a normal artery (6.9 kPa). However, the stenotic artery with an asymmetric plaque had a much lower critical buckling pressure (5.5 kPa) (Figure 2). The post-buckling deflection increased rapidly for the stenotic artery with asymmetric plaque compared to normal artery, whereas stenotic artery with symmetric plaque had a slightly slower rise in the deflection.


Artery buckling affects the mechanical stress in atherosclerotic plaques.

Sanyal A, Han HC - Biomed Eng Online (2015)

Buckling displacement (maximum deflection at the middle) plotted as function of lumen pressure of a normal artery, artery with symmetric plaque, and artery with an asymmetric plaque.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4306115&req=5

Figure 2: Buckling displacement (maximum deflection at the middle) plotted as function of lumen pressure of a normal artery, artery with symmetric plaque, and artery with an asymmetric plaque.
Mentions: The presence of an atherosclerotic plaque affects the critical buckling pressure of a coronary artery. The buckling behavior of the stenotic artery with plaque was different from the normal artery and different for symmetric and asymmetric plaques. The stenotic artery with a symmetric plaque had a critical buckling pressure (7.0 kPa) close to that of a normal artery (6.9 kPa). However, the stenotic artery with an asymmetric plaque had a much lower critical buckling pressure (5.5 kPa) (Figure 2). The post-buckling deflection increased rapidly for the stenotic artery with asymmetric plaque compared to normal artery, whereas stenotic artery with symmetric plaque had a slightly slower rise in the deflection.

Bottom Line: Tortuous arteries are often seen in patients with hypertension and atherosclerosis.Artery with asymmetric plaque had lower critical buckling pressure compared to the artery with symmetric plaque and control artery.Stiffer calcified tissue and severe stenosis increased the critical buckling pressure of the artery with asymmetric plaque.

View Article: PubMed Central - HTML - PubMed

ABSTRACT

Background: Tortuous arteries are often seen in patients with hypertension and atherosclerosis. While the mechanical stress in atherosclerotic plaque under lumen pressure has been studied extensively, the mechanical stability of atherosclerotic arteries and subsequent effect on the plaque stress remain unknown. To this end, we investigated the buckling and post-buckling behavior of model stenotic coronary arteries with symmetric and asymmetric plaque.

Methods: Buckling analysis for a model coronary artery with symmetric and asymmetric plaque was conducted using finite element analysis based on the dimensions and nonlinear anisotropic materials properties reported in the literature.

Results: Artery with asymmetric plaque had lower critical buckling pressure compared to the artery with symmetric plaque and control artery. Buckling increased the peak stress in the plaque and led to the development of a high stress concentration in artery with asymmetric plaque. Stiffer calcified tissue and severe stenosis increased the critical buckling pressure of the artery with asymmetric plaque.

Conclusions: Arteries with atherosclerotic plaques are prone to mechanical buckling which leads to a high stress concentration in the plaques that can possibly make the plaques prone to rupture.

Show MeSH
Related in: MedlinePlus