Longitudinal diffusion tensor imaging in frontotemporal dementia.
Bottom Line: MAPT carriers had the greatest change within left uncinate fasciculus (FA: -7.9%/yr, p < 0.001; MD: 10.9%/yr, p < 0.001); sporadic bvFTD and C9ORF72 carriers had the greatest change within right paracallosal cingulum (sporadic bvFTD, FA: -6.7%/yr, p < 0.001; MD: 3.8%/yr, p = 0.001; C9ORF72, FA: -6.8%/yr, p = 0.004).Sample size estimates using FA change were substantially lower than neuropsychological or whole brain measures of change.Serial DTI scans may be useful for measuring disease progression in bvFTD, with particular trajectories of WM damage emerging.
Affiliation: Dementia Research Centre, UCL Institute of Neurology, University College London, London, United Kingdom.Show MeSH
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Mentions: Rates of change for each region of interest and diffusivity metric are shown in Table4 and Figures 2 and 3 (see Supplementary Table3 for RD and AX). Longitudinally, compared with cognitively normal participants, bvFTD patients as a group had the largest reductions in FA within bilateral paracallosal cingulum (right: −6.8%/yr, 95% CI = −8.0 to −2.7%, p < 0.001; left, −5.5%/yr, 95% CI = −6.9 to −2.2%, p < 0.001) and bilateral uncinate fasciculus (right, −4.2%/yr, 95% CI = −8.7 to −2.7%, p < 0.001; left: −3.1%/yr, 95% CI = −8.6 to −1.5%, p = 0.005). The largest increases in MD were within bilateral uncinate fasciculus (right: 5.1%/yr, 95% CI = 2.3 to 8.0%, p < 0.001; left: 6.2%/yr, 95% CI = 1.6 to 10.8%, p = 0.01;) and bilateral parahippocampal cingulum (right: 4.3%/yr, 95% CI = 1.6 to 7.1%, p = 0.002; left, 5.0%/yr, 95% CI = 1.1 to 9.0%, p = 0.01).
Affiliation: Dementia Research Centre, UCL Institute of Neurology, University College London, London, United Kingdom.