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Longitudinal diffusion tensor imaging in frontotemporal dementia.

Mahoney CJ, Simpson IJ, Nicholas JM, Fletcher PD, Downey LE, Golden HL, Clark CN, Schmitz N, Rohrer JD, Schott JM, Zhang H, Ourselin S, Warren JD, Fox NC - Ann. Neurol. (2014)

Bottom Line: MAPT carriers had the greatest change within left uncinate fasciculus (FA: -7.9%/yr, p < 0.001; MD: 10.9%/yr, p < 0.001); sporadic bvFTD and C9ORF72 carriers had the greatest change within right paracallosal cingulum (sporadic bvFTD, FA: -6.7%/yr, p < 0.001; MD: 3.8%/yr, p = 0.001; C9ORF72, FA: -6.8%/yr, p = 0.004).Sample size estimates using FA change were substantially lower than neuropsychological or whole brain measures of change.Serial DTI scans may be useful for measuring disease progression in bvFTD, with particular trajectories of WM damage emerging.

View Article: PubMed Central - PubMed

Affiliation: Dementia Research Centre, UCL Institute of Neurology, University College London, London, United Kingdom.

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Related in: MedlinePlus

Plots of each participant's fractional anisotropy (FA) over time within the uncinate fasciculus and paracallosal (PC) cingulum bundle. Each line represents a single subject, with behavioral variant frontotemporal dementia (bvFTD) participants along the left and controls along the right. Red dashed lines indicate the mean trajectory. L = left; R = right. [Color figure can be viewed in the online issue, which is available at http://www.annalsofneurology.org.]
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fig03: Plots of each participant's fractional anisotropy (FA) over time within the uncinate fasciculus and paracallosal (PC) cingulum bundle. Each line represents a single subject, with behavioral variant frontotemporal dementia (bvFTD) participants along the left and controls along the right. Red dashed lines indicate the mean trajectory. L = left; R = right. [Color figure can be viewed in the online issue, which is available at http://www.annalsofneurology.org.]

Mentions: Rates of change for each region of interest and diffusivity metric are shown in Table4 and Figures 2 and 3 (see Supplementary Table3 for RD and AX). Longitudinally, compared with cognitively normal participants, bvFTD patients as a group had the largest reductions in FA within bilateral paracallosal cingulum (right: −6.8%/yr, 95% CI = −8.0 to −2.7%, p < 0.001; left, −5.5%/yr, 95% CI = −6.9 to −2.2%, p < 0.001) and bilateral uncinate fasciculus (right, −4.2%/yr, 95% CI = −8.7 to −2.7%, p < 0.001; left: −3.1%/yr, 95% CI = −8.6 to −1.5%, p = 0.005). The largest increases in MD were within bilateral uncinate fasciculus (right: 5.1%/yr, 95% CI = 2.3 to 8.0%, p < 0.001; left: 6.2%/yr, 95% CI = 1.6 to 10.8%, p = 0.01;) and bilateral parahippocampal cingulum (right: 4.3%/yr, 95% CI = 1.6 to 7.1%, p = 0.002; left, 5.0%/yr, 95% CI = 1.1 to 9.0%, p = 0.01).


Longitudinal diffusion tensor imaging in frontotemporal dementia.

Mahoney CJ, Simpson IJ, Nicholas JM, Fletcher PD, Downey LE, Golden HL, Clark CN, Schmitz N, Rohrer JD, Schott JM, Zhang H, Ourselin S, Warren JD, Fox NC - Ann. Neurol. (2014)

Plots of each participant's fractional anisotropy (FA) over time within the uncinate fasciculus and paracallosal (PC) cingulum bundle. Each line represents a single subject, with behavioral variant frontotemporal dementia (bvFTD) participants along the left and controls along the right. Red dashed lines indicate the mean trajectory. L = left; R = right. [Color figure can be viewed in the online issue, which is available at http://www.annalsofneurology.org.]
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4305215&req=5

fig03: Plots of each participant's fractional anisotropy (FA) over time within the uncinate fasciculus and paracallosal (PC) cingulum bundle. Each line represents a single subject, with behavioral variant frontotemporal dementia (bvFTD) participants along the left and controls along the right. Red dashed lines indicate the mean trajectory. L = left; R = right. [Color figure can be viewed in the online issue, which is available at http://www.annalsofneurology.org.]
Mentions: Rates of change for each region of interest and diffusivity metric are shown in Table4 and Figures 2 and 3 (see Supplementary Table3 for RD and AX). Longitudinally, compared with cognitively normal participants, bvFTD patients as a group had the largest reductions in FA within bilateral paracallosal cingulum (right: −6.8%/yr, 95% CI = −8.0 to −2.7%, p < 0.001; left, −5.5%/yr, 95% CI = −6.9 to −2.2%, p < 0.001) and bilateral uncinate fasciculus (right, −4.2%/yr, 95% CI = −8.7 to −2.7%, p < 0.001; left: −3.1%/yr, 95% CI = −8.6 to −1.5%, p = 0.005). The largest increases in MD were within bilateral uncinate fasciculus (right: 5.1%/yr, 95% CI = 2.3 to 8.0%, p < 0.001; left: 6.2%/yr, 95% CI = 1.6 to 10.8%, p = 0.01;) and bilateral parahippocampal cingulum (right: 4.3%/yr, 95% CI = 1.6 to 7.1%, p = 0.002; left, 5.0%/yr, 95% CI = 1.1 to 9.0%, p = 0.01).

Bottom Line: MAPT carriers had the greatest change within left uncinate fasciculus (FA: -7.9%/yr, p < 0.001; MD: 10.9%/yr, p < 0.001); sporadic bvFTD and C9ORF72 carriers had the greatest change within right paracallosal cingulum (sporadic bvFTD, FA: -6.7%/yr, p < 0.001; MD: 3.8%/yr, p = 0.001; C9ORF72, FA: -6.8%/yr, p = 0.004).Sample size estimates using FA change were substantially lower than neuropsychological or whole brain measures of change.Serial DTI scans may be useful for measuring disease progression in bvFTD, with particular trajectories of WM damage emerging.

View Article: PubMed Central - PubMed

Affiliation: Dementia Research Centre, UCL Institute of Neurology, University College London, London, United Kingdom.

Show MeSH
Related in: MedlinePlus