A novel immune competent murine hypertrophic scar contracture model: a tool to elucidate disease mechanism and develop new therapies.
Bottom Line: Current therapies are marginally effective.Outcomes were compared with human condition to validate the model.Macrophages and mast cells were increased. qRT-PCR showed up-regulation of transforming growth factor beta, alpha smooth muscle actin, and rho-associated protein kinase 2 in HSc.
Affiliation: Division of Plastic and Reconstructive Surgery, Department of Surgery, Duke University School of Medicine, Durham, North Carolina.Show MeSH
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Mentions: A third-degree burn injures the full thickness of the skin: the epidermis and the dermis.19 Histological analysis revealed that a 1-second burn contact time with a 65 g brass rod heated to 100 °C, held in place by gravity, resulted in a reproducible full-thickness burn (Figure 1A). As is noted in the figure, there was necrosis throughout the epidermis and dermis, but not into the deep muscular layer.
Affiliation: Division of Plastic and Reconstructive Surgery, Department of Surgery, Duke University School of Medicine, Durham, North Carolina.