Evaluation of association of maternal IL-10 polymorphisms with risk of preeclampsia by A meta-analysis.
Bottom Line: However, various published results were inconsistent.Our meta-analysis results indicated that IL-10 -819 C/T (C versus T, OR = 1.28, 95% CI = 1.08-1.50, P = 0.003) and -592 C/A (C versus A, OR = 1.28, 95% CI = 1.03-1.59, P = 0.03) polymorphisms were associated with preeclampsia.Although there was no overall association between -1082 A/G polymorphism and preeclampsia (G versus A, OR = 0.93, 95% CI = 0.77-1.13, P = 0.49), such association existed among Asian (G versus A, OR = 1.29, 95% CI = 1.04-1.60, P = 0.02) and South American (G versus A, OR = 0.72, 95% CI = 0.54-0.94, P = 0.02) populations in the subgroup analysis stratified by continents.
Affiliation: Management Department, Shanghai Medical Instrumentation College, Shanghai, China.Show MeSH
Related in: MedlinePlus
Mentions: In the subgroup analysis stratified by continents, we found that the heterogeneity was significantly lower in the Asia (Pheterogeneity = 0.35, I2 = 6%), Europe (Pheterogeneity = 0.58, I2 = 0%), South America (Pheterogeneity = 0.91, I2 = 0%) and North America groups (Pheterogeneity = 0.37, I2 = 0%) than in the whole population (Pheterogeneity = 0.002, I2 = 63%; Fig. 2). Therefore, the regions where the individual studies were performed could explain the source of heterogeneity. This result was somewhat reminiscent of Daher et al.'s previous report that the association between IL-10 -1082A/G polymorphism and preeclampsia were only observed in white women instead of non-white women . However, our meta-analysis results based upon four previously published relevant studies did not support the association between IL-10 -1082A/G polymorphism and the risk of preeclampsia among white women under the allelic model (G allele versus A allele, OR = 0.83, 95% CI = 0.56–1.21, P = 0.32; Fig. 3).
Affiliation: Management Department, Shanghai Medical Instrumentation College, Shanghai, China.