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Satellite glial cells in dorsal root ganglia are activated in streptozotocin-treated rodents.

Hanani M, Blum E, Liu S, Peng L, Liang S - J. Cell. Mol. Med. (2014)

Bottom Line: As DM is becoming a global epidemic it is important to understand and treat this problem.We carried out immunohistochemical studies to learn about changes in the activation marker glial fibrillary acidic protein (GFAP) in SGCs.These results indicate for the first time that SGCs are activated in rodent models of DM1.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Experimental Surgery, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.

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Related in: MedlinePlus

GFAP was up-regulated in rat DRG 14 days after STZ injection, as demonstrated by Western blot study. GFAP protein expression in STZ-treated rats was significantly increased in comparison with that in control rats. N = 6 for each of the groups. The asterisk indicates P < 0.05 compared with control, error bars indicate SD.
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fig04: GFAP was up-regulated in rat DRG 14 days after STZ injection, as demonstrated by Western blot study. GFAP protein expression in STZ-treated rats was significantly increased in comparison with that in control rats. N = 6 for each of the groups. The asterisk indicates P < 0.05 compared with control, error bars indicate SD.

Mentions: To obtain quantitative information on the changes in GFAP in STZ-treated rats, we carried out a Western blot study. As shown in Figure 4, there was an over 2-fold increase in the amount of GFAP protein, in accord with the immunostaining results.


Satellite glial cells in dorsal root ganglia are activated in streptozotocin-treated rodents.

Hanani M, Blum E, Liu S, Peng L, Liang S - J. Cell. Mol. Med. (2014)

GFAP was up-regulated in rat DRG 14 days after STZ injection, as demonstrated by Western blot study. GFAP protein expression in STZ-treated rats was significantly increased in comparison with that in control rats. N = 6 for each of the groups. The asterisk indicates P < 0.05 compared with control, error bars indicate SD.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4302642&req=5

fig04: GFAP was up-regulated in rat DRG 14 days after STZ injection, as demonstrated by Western blot study. GFAP protein expression in STZ-treated rats was significantly increased in comparison with that in control rats. N = 6 for each of the groups. The asterisk indicates P < 0.05 compared with control, error bars indicate SD.
Mentions: To obtain quantitative information on the changes in GFAP in STZ-treated rats, we carried out a Western blot study. As shown in Figure 4, there was an over 2-fold increase in the amount of GFAP protein, in accord with the immunostaining results.

Bottom Line: As DM is becoming a global epidemic it is important to understand and treat this problem.We carried out immunohistochemical studies to learn about changes in the activation marker glial fibrillary acidic protein (GFAP) in SGCs.These results indicate for the first time that SGCs are activated in rodent models of DM1.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Experimental Surgery, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.

Show MeSH
Related in: MedlinePlus