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Mechanotransduction in intervertebral discs.

Tsai TT, Cheng CM, Chen CF, Lai PL - J. Cell. Mol. Med. (2014)

Bottom Line: Accordingly, aberrant mechanotransduction can either lead to, or be a result of, a variety of diseases or degenerative states.In this review, we provide an overview of mechanotransduction in the context of intervertebral discs, with a focus on the latest methods of investigating mechanotransduction and the most recent findings regarding the means and effects of mechanotransduction in healthy and degenerative discs.We also provide some discussion of potential directions for future research and treatments.

View Article: PubMed Central - PubMed

Affiliation: Department of Orthopaedic Surgery, Spine Section, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taoyuan, Taiwan.

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A suggested model for the regulation of c-fos expression via MAPK signaling and PKC signaling in NP cells. (Figure adapted from Yokoyama K, Hiyama A, Arai F, et al. C-Fos regulation by the MAPK and PKC pathways in intervertebral disc cells. PLoS ONE. 2013; 8: e73210.)
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fig02: A suggested model for the regulation of c-fos expression via MAPK signaling and PKC signaling in NP cells. (Figure adapted from Yokoyama K, Hiyama A, Arai F, et al. C-Fos regulation by the MAPK and PKC pathways in intervertebral disc cells. PLoS ONE. 2013; 8: e73210.)

Mentions: Understanding mechanotransduction can be difficult because of the sheer complexity of the systems involved. To take an example directly relevant to the topic of this review, Figure 2 provides a model of how a mitogen-activated protein kinase (MAPK) mechanotransduction signalling pathway (which also involves phorbol 12-myristate 13-acetate and protein kinase C) may serve to regulate c-fos expression in nucleus pulposus cells in the context of both intervertebral disc (IVD) degeneration and regeneration [15]. For many readers, both the preceding sentence and Figure 2 will likely seem fairly difficult to decipher. However, in the course, of this review, we hope to break the complex process of mechanotransduction down into more simple and understandable components, to make Figure 2 and similar models of the process substantially easier to understand.


Mechanotransduction in intervertebral discs.

Tsai TT, Cheng CM, Chen CF, Lai PL - J. Cell. Mol. Med. (2014)

A suggested model for the regulation of c-fos expression via MAPK signaling and PKC signaling in NP cells. (Figure adapted from Yokoyama K, Hiyama A, Arai F, et al. C-Fos regulation by the MAPK and PKC pathways in intervertebral disc cells. PLoS ONE. 2013; 8: e73210.)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4302640&req=5

fig02: A suggested model for the regulation of c-fos expression via MAPK signaling and PKC signaling in NP cells. (Figure adapted from Yokoyama K, Hiyama A, Arai F, et al. C-Fos regulation by the MAPK and PKC pathways in intervertebral disc cells. PLoS ONE. 2013; 8: e73210.)
Mentions: Understanding mechanotransduction can be difficult because of the sheer complexity of the systems involved. To take an example directly relevant to the topic of this review, Figure 2 provides a model of how a mitogen-activated protein kinase (MAPK) mechanotransduction signalling pathway (which also involves phorbol 12-myristate 13-acetate and protein kinase C) may serve to regulate c-fos expression in nucleus pulposus cells in the context of both intervertebral disc (IVD) degeneration and regeneration [15]. For many readers, both the preceding sentence and Figure 2 will likely seem fairly difficult to decipher. However, in the course, of this review, we hope to break the complex process of mechanotransduction down into more simple and understandable components, to make Figure 2 and similar models of the process substantially easier to understand.

Bottom Line: Accordingly, aberrant mechanotransduction can either lead to, or be a result of, a variety of diseases or degenerative states.In this review, we provide an overview of mechanotransduction in the context of intervertebral discs, with a focus on the latest methods of investigating mechanotransduction and the most recent findings regarding the means and effects of mechanotransduction in healthy and degenerative discs.We also provide some discussion of potential directions for future research and treatments.

View Article: PubMed Central - PubMed

Affiliation: Department of Orthopaedic Surgery, Spine Section, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taoyuan, Taiwan.

Show MeSH