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Cutaneous lymphocyte antigen expression loss and PD1 positivity in early cutaneous lesions of rapidly progressive mycosis fungoides.

Ogunrinade O, Ahn CS, Gergis U, Yassin AH, Magro C - Clin Case Rep (2014)

Bottom Line: It's important to assess cases both clinically and pathologically for factors potentially predictive of an aggressive clinical course.We concluded that the relative immunosuppressive effects of PD1 may contribute to tumor progression while the lack of staining for cutaneous lymphocyte antigen may be an additional factor facilitating distant extracutaneous migration.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Weill Cornell Medical College New York City, New York, 10065.

ABSTRACT

Key clinical message: It's important to assess cases both clinically and pathologically for factors potentially predictive of an aggressive clinical course. We concluded that the relative immunosuppressive effects of PD1 may contribute to tumor progression while the lack of staining for cutaneous lymphocyte antigen may be an additional factor facilitating distant extracutaneous migration.

No MeSH data available.


Related in: MedlinePlus

(A) The lymph node sample performed in October, 2011 shows expansion and replacement of the paracortex by highly atypical neoplastic T lymphocytes of presumptive cutaneous origin. (B) Higher power magnification demonstrates the pleomorphic intermediate and large-sized lymphocytes with abundant cytoplasm and marked nuclear hyperchromasia. They also appear to focally infiltrate the germinal center and surrounding mantle zone. The cells are cytomorphologically.
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fig10: (A) The lymph node sample performed in October, 2011 shows expansion and replacement of the paracortex by highly atypical neoplastic T lymphocytes of presumptive cutaneous origin. (B) Higher power magnification demonstrates the pleomorphic intermediate and large-sized lymphocytes with abundant cytoplasm and marked nuclear hyperchromasia. They also appear to focally infiltrate the germinal center and surrounding mantle zone. The cells are cytomorphologically.

Mentions: A left inguinal lymph node biopsy performed in October of 2011 demonstrated a normal architecture largely effaced by a diffuse paracortical proliferation composed of small, medium-sized to large cells (Figs.10A and B). Residual reactive-appearing lymphoid follicles are seen. The neoplastic cells demonstrated a hyperconvoluted cerebriform appearance, similar to those in the skinbiopsy. The findings were characteristic for MF involving the lymph node.


Cutaneous lymphocyte antigen expression loss and PD1 positivity in early cutaneous lesions of rapidly progressive mycosis fungoides.

Ogunrinade O, Ahn CS, Gergis U, Yassin AH, Magro C - Clin Case Rep (2014)

(A) The lymph node sample performed in October, 2011 shows expansion and replacement of the paracortex by highly atypical neoplastic T lymphocytes of presumptive cutaneous origin. (B) Higher power magnification demonstrates the pleomorphic intermediate and large-sized lymphocytes with abundant cytoplasm and marked nuclear hyperchromasia. They also appear to focally infiltrate the germinal center and surrounding mantle zone. The cells are cytomorphologically.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4302628&req=5

fig10: (A) The lymph node sample performed in October, 2011 shows expansion and replacement of the paracortex by highly atypical neoplastic T lymphocytes of presumptive cutaneous origin. (B) Higher power magnification demonstrates the pleomorphic intermediate and large-sized lymphocytes with abundant cytoplasm and marked nuclear hyperchromasia. They also appear to focally infiltrate the germinal center and surrounding mantle zone. The cells are cytomorphologically.
Mentions: A left inguinal lymph node biopsy performed in October of 2011 demonstrated a normal architecture largely effaced by a diffuse paracortical proliferation composed of small, medium-sized to large cells (Figs.10A and B). Residual reactive-appearing lymphoid follicles are seen. The neoplastic cells demonstrated a hyperconvoluted cerebriform appearance, similar to those in the skinbiopsy. The findings were characteristic for MF involving the lymph node.

Bottom Line: It's important to assess cases both clinically and pathologically for factors potentially predictive of an aggressive clinical course.We concluded that the relative immunosuppressive effects of PD1 may contribute to tumor progression while the lack of staining for cutaneous lymphocyte antigen may be an additional factor facilitating distant extracutaneous migration.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Weill Cornell Medical College New York City, New York, 10065.

ABSTRACT

Key clinical message: It's important to assess cases both clinically and pathologically for factors potentially predictive of an aggressive clinical course. We concluded that the relative immunosuppressive effects of PD1 may contribute to tumor progression while the lack of staining for cutaneous lymphocyte antigen may be an additional factor facilitating distant extracutaneous migration.

No MeSH data available.


Related in: MedlinePlus