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Higher blood aldosterone level in metabolic syndrome is independently related to adiposity and fasting plasma glucose.

Chiang JK, Chen CL, Tseng FY, Chi YC, Huang KC, Yang WS - Cardiovasc Diabetol (2015)

Bottom Line: We found an inverse correlation between blood adiponectin and aldosterone (γ = -0.11, P = 0.009).Although aldosterone was significantly related to body fat %, fasting plasma glucose and serum creatinine levels, the relationship between adiponectin and aldosterone was not obvious after adjustment in the multivariate analysis.Although aldosterone was related to metabolic factors, including body fat % and fasting plasma glucose in our female subjects, the relationship between aldosterone and adiponectin remains unclear.

View Article: PubMed Central - PubMed

Affiliation: Department of Family Medicine, Buddhist Dalin Tzu Chi Hospital, Chiayi, Taiwan. jkch68@gmail.com.

ABSTRACT

Background: Hypoadiponectinemia is a well-known state associated with metabolic syndrome (MetS) and insulin resistance (IR). Recently aldosterone has been highly associated with high blood pressure, and may thus be a possible biomarker for MetS and IR. In this study, we investigate the association of aldosterone with MetS and IR, and compare it with that of adiponectin.

Methods: In this cross-sectional study, we recruited 556 women receiving physical examinations at a general hospital in central Taiwan. At the time of examination, we collected data on various demographic and physical characteristics and measured blood levels of aldosterone, adiponectin and a variety of metabolic factors. Multiple linear regression analysis was performed using adiponectin or aldosterone as the dependent variables.

Results: We found an inverse correlation between blood adiponectin and aldosterone (γ = -0.11, P = 0.009). Adiponectin levels were lower and aldosterone levels higher in women with MetS that those without (8.1 ± 0.4 vs. 11.5 ± 0.2 μg/mL, P < 0.001 and 691 ± 50 vs. 560 ± 11 pmol/L, P = 0.013, respectively), as they were in women with and without IR (adiponectin 10.4 ± 0.5 vs. 11.3 ± 0.2 μg/mL, P = 0.003 and aldosterone 635 ± 31 vs. 560 ± 11 pmol/L, P = 0.022). Although aldosterone was significantly related to body fat %, fasting plasma glucose and serum creatinine levels, the relationship between adiponectin and aldosterone was not obvious after adjustment in the multivariate analysis.

Conclusion: Although aldosterone was related to metabolic factors, including body fat % and fasting plasma glucose in our female subjects, the relationship between aldosterone and adiponectin remains unclear.

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Related in: MedlinePlus

The blood (A) adiponectin levels (Mean ± SEM) and (B) aldosterone levels (Mean ± SEM) in subjects with or without MetS or by the number of the MetS criteria met.
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Fig1: The blood (A) adiponectin levels (Mean ± SEM) and (B) aldosterone levels (Mean ± SEM) in subjects with or without MetS or by the number of the MetS criteria met.

Mentions: The subjects were categorized into those with metabolic syndrome (MetS) and non-MetS groups (Table 2). Adiponectin levels in those with MetS (n = 77, 13.8%) were about around thirty percent lower (mean ± SEM: 8.1 ± 0.4 vs. 11.5 ± 0.2 μg/mL, p < 0.001, Figure 1A). Those meeting none, 1, 2 and 3 and more of the criteria for MetS had blood adiponectin levels of 12.1 ± 0.3, 11.5 ± 0.4, 10.2 ± 0.4 and 8.1 ± 0.4 μg/mL, respectively (mean ± SEM., p for trend = 0.030, Figure 1A), while they had about 19% higher levels of aldosterone (mean ± SEM: 691 ± 50 vs. 560 ± 11 pmol/L, p = 0.013 with unequal variances, Figure 1B). The subjects meeting none, 1, 2 and 3 and more criteria for MetS had blood aldosterone levels of 574 ± 17, 558 ± 17, 530 ± 25 and 694 ± 50 pmol/L, respectively (mean ± SEM., p for trend = 0.410, Figure 1B).Table 2


Higher blood aldosterone level in metabolic syndrome is independently related to adiposity and fasting plasma glucose.

Chiang JK, Chen CL, Tseng FY, Chi YC, Huang KC, Yang WS - Cardiovasc Diabetol (2015)

The blood (A) adiponectin levels (Mean ± SEM) and (B) aldosterone levels (Mean ± SEM) in subjects with or without MetS or by the number of the MetS criteria met.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4302513&req=5

Fig1: The blood (A) adiponectin levels (Mean ± SEM) and (B) aldosterone levels (Mean ± SEM) in subjects with or without MetS or by the number of the MetS criteria met.
Mentions: The subjects were categorized into those with metabolic syndrome (MetS) and non-MetS groups (Table 2). Adiponectin levels in those with MetS (n = 77, 13.8%) were about around thirty percent lower (mean ± SEM: 8.1 ± 0.4 vs. 11.5 ± 0.2 μg/mL, p < 0.001, Figure 1A). Those meeting none, 1, 2 and 3 and more of the criteria for MetS had blood adiponectin levels of 12.1 ± 0.3, 11.5 ± 0.4, 10.2 ± 0.4 and 8.1 ± 0.4 μg/mL, respectively (mean ± SEM., p for trend = 0.030, Figure 1A), while they had about 19% higher levels of aldosterone (mean ± SEM: 691 ± 50 vs. 560 ± 11 pmol/L, p = 0.013 with unequal variances, Figure 1B). The subjects meeting none, 1, 2 and 3 and more criteria for MetS had blood aldosterone levels of 574 ± 17, 558 ± 17, 530 ± 25 and 694 ± 50 pmol/L, respectively (mean ± SEM., p for trend = 0.410, Figure 1B).Table 2

Bottom Line: We found an inverse correlation between blood adiponectin and aldosterone (γ = -0.11, P = 0.009).Although aldosterone was significantly related to body fat %, fasting plasma glucose and serum creatinine levels, the relationship between adiponectin and aldosterone was not obvious after adjustment in the multivariate analysis.Although aldosterone was related to metabolic factors, including body fat % and fasting plasma glucose in our female subjects, the relationship between aldosterone and adiponectin remains unclear.

View Article: PubMed Central - PubMed

Affiliation: Department of Family Medicine, Buddhist Dalin Tzu Chi Hospital, Chiayi, Taiwan. jkch68@gmail.com.

ABSTRACT

Background: Hypoadiponectinemia is a well-known state associated with metabolic syndrome (MetS) and insulin resistance (IR). Recently aldosterone has been highly associated with high blood pressure, and may thus be a possible biomarker for MetS and IR. In this study, we investigate the association of aldosterone with MetS and IR, and compare it with that of adiponectin.

Methods: In this cross-sectional study, we recruited 556 women receiving physical examinations at a general hospital in central Taiwan. At the time of examination, we collected data on various demographic and physical characteristics and measured blood levels of aldosterone, adiponectin and a variety of metabolic factors. Multiple linear regression analysis was performed using adiponectin or aldosterone as the dependent variables.

Results: We found an inverse correlation between blood adiponectin and aldosterone (γ = -0.11, P = 0.009). Adiponectin levels were lower and aldosterone levels higher in women with MetS that those without (8.1 ± 0.4 vs. 11.5 ± 0.2 μg/mL, P < 0.001 and 691 ± 50 vs. 560 ± 11 pmol/L, P = 0.013, respectively), as they were in women with and without IR (adiponectin 10.4 ± 0.5 vs. 11.3 ± 0.2 μg/mL, P = 0.003 and aldosterone 635 ± 31 vs. 560 ± 11 pmol/L, P = 0.022). Although aldosterone was significantly related to body fat %, fasting plasma glucose and serum creatinine levels, the relationship between adiponectin and aldosterone was not obvious after adjustment in the multivariate analysis.

Conclusion: Although aldosterone was related to metabolic factors, including body fat % and fasting plasma glucose in our female subjects, the relationship between aldosterone and adiponectin remains unclear.

Show MeSH
Related in: MedlinePlus