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QT Dispersion after Thrombolytic Therapy.

Oni Heris S, Rahimi B, Faridaalaee G, Hajahmadi M, Sayyadi H, Naghipour B - Int Cardiovasc Res J (2014)

Bottom Line: Besides, P ≤ 0.05 was considered as statistically significant.The results revealed no significant differences among QTd 1, QTd 2, and QTd 3 (P > 0.05).At inferior AMI, however, a significant difference was observed among QTd1, QTd2, and QTd3 (P = 0.031).

View Article: PubMed Central - PubMed

Affiliation: Shahid Rajaee Heart Center, Tehran, IR Iran.

ABSTRACT

Background: QT dispersion (QTd) is equal to longer QTc minus shorter QTc measured by 12-lead electrocardiogram (ECG). QTd reflects inhomogeneity in repolarization of ventricular myocardium and because of easy and fast measurement of QTd, it can be used to predict high-risk patients for dysrhythmia after Acute Myocardial Infarction (AMI).

Objectives: This study aimed to assess the effect of thrombolytic therapy on QTd before and 1 hour and 4 days after beginning of thrombolytic therapy.

Patients and methods: The patients with chest pain and ST Elevated Myocardial Infarction (STEMI) that underwent thrombolytic therapy were enrolled into this study. Streptokinase was the thrombolytic agent in all the patients. Standard 12-lead (ECG) was evaluated before beginning of thrombolytic therapy (QTd 1) and 1 hour (QTd2) and 4 days (QTd3) after thrombolytic therapy. First, ECG was magnified × 10 for exact calculation of QT and QTd. After all, the variables were compared using one-way analysis of variance (ANOVA). Besides, P ≤ 0.05 was considered as statistically significant.

Results: This study was conducted on 160 patients. The results revealed no significant differences among QTd 1, QTd 2, and QTd 3 (P > 0.05). At inferior AMI, however, a significant difference was observed among QTd1, QTd2, and QTd3 (P = 0.031).

Conclusions: Thrombolytic therapy had no significant effects on QTd. Thus, thrombolytic therapy does not increase the risk of arrhythmia.

No MeSH data available.


Related in: MedlinePlus

QTd Mean Variation over Time Based on the Site of Infarction
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fig13728: QTd Mean Variation over Time Based on the Site of Infarction

Mentions: Moreover, over time QTd variation based on sex, age, site of infarction, previous smoking, hypertension, and diabetes mellitus has been shown in Table 3. As the table depicts, no significant differences were found among QTd 1, QTd 2, and QTd 3 (P > 0.05). At inferior AMI, however, a significant difference was observed among QTd1, QTd2, and QTd3 (P = 0.031). Over time QTd mean variations based on the site of infarction have been presented in Figure 2.


QT Dispersion after Thrombolytic Therapy.

Oni Heris S, Rahimi B, Faridaalaee G, Hajahmadi M, Sayyadi H, Naghipour B - Int Cardiovasc Res J (2014)

QTd Mean Variation over Time Based on the Site of Infarction
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4302504&req=5

fig13728: QTd Mean Variation over Time Based on the Site of Infarction
Mentions: Moreover, over time QTd variation based on sex, age, site of infarction, previous smoking, hypertension, and diabetes mellitus has been shown in Table 3. As the table depicts, no significant differences were found among QTd 1, QTd 2, and QTd 3 (P > 0.05). At inferior AMI, however, a significant difference was observed among QTd1, QTd2, and QTd3 (P = 0.031). Over time QTd mean variations based on the site of infarction have been presented in Figure 2.

Bottom Line: Besides, P ≤ 0.05 was considered as statistically significant.The results revealed no significant differences among QTd 1, QTd 2, and QTd 3 (P > 0.05).At inferior AMI, however, a significant difference was observed among QTd1, QTd2, and QTd3 (P = 0.031).

View Article: PubMed Central - PubMed

Affiliation: Shahid Rajaee Heart Center, Tehran, IR Iran.

ABSTRACT

Background: QT dispersion (QTd) is equal to longer QTc minus shorter QTc measured by 12-lead electrocardiogram (ECG). QTd reflects inhomogeneity in repolarization of ventricular myocardium and because of easy and fast measurement of QTd, it can be used to predict high-risk patients for dysrhythmia after Acute Myocardial Infarction (AMI).

Objectives: This study aimed to assess the effect of thrombolytic therapy on QTd before and 1 hour and 4 days after beginning of thrombolytic therapy.

Patients and methods: The patients with chest pain and ST Elevated Myocardial Infarction (STEMI) that underwent thrombolytic therapy were enrolled into this study. Streptokinase was the thrombolytic agent in all the patients. Standard 12-lead (ECG) was evaluated before beginning of thrombolytic therapy (QTd 1) and 1 hour (QTd2) and 4 days (QTd3) after thrombolytic therapy. First, ECG was magnified × 10 for exact calculation of QT and QTd. After all, the variables were compared using one-way analysis of variance (ANOVA). Besides, P ≤ 0.05 was considered as statistically significant.

Results: This study was conducted on 160 patients. The results revealed no significant differences among QTd 1, QTd 2, and QTd 3 (P > 0.05). At inferior AMI, however, a significant difference was observed among QTd1, QTd2, and QTd3 (P = 0.031).

Conclusions: Thrombolytic therapy had no significant effects on QTd. Thus, thrombolytic therapy does not increase the risk of arrhythmia.

No MeSH data available.


Related in: MedlinePlus