Limits...
Assessment of the Relationship between Galectin-3 and Ejection Fraction and Functional Capacity in the Patients with Compensated Systolic Heart Failure.

Atabakhshian R, Kazerouni F, Raygan F, Amirrasouli H, Rahimipour A, Shakeri N - Int Cardiovasc Res J (2014)

Bottom Line: P < 0.05 was considered as statistically significant.The results revealed no significant correlation between Galectin-3 and age, body mass index, and estimated glomerular filtration rate.Yet, a significant difference was found between males and females regarding the mean of Galectin-3 (P = 0.039).

View Article: PubMed Central - PubMed

Affiliation: Department of Laboratory Medicine, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran.

ABSTRACT

Background: Galectin-3 is a soluble ß-galactoside-binding lectin released by activated cardiac macrophages. Galectin-3 has been proposed for diagnosis and prognosis of HF patients.

Objectives: The present study aimed to investigate the relationship between galectin-3 as a biomarker and ejection fraction and functional capacity in the patients with compensated systolic heart failure.

Patients and methods: In this study, serum levels of Galectin-3 were measured in 76 patients with compensated heart failure with New York Heart Association class I-IV and left ventricular ejection fraction < 45%. Galectin-3 was measured by an ELISA kit. Besides, echocardiography was used to evaluate left ventricular ejection fraction. Additionally, functional capacity was determined based on the patients' ability to perform a set of activities. After all, the data were analyzed used t-test, Kruskal-Wallis, one-way ANOVA, and chi-square test. P < 0.05 was considered as statistically significant.

Results: The patients' age ranged from 45 to 75 years, with the mean age of 63.85 ± 9 years. In addition 57.9% of the patients were male. The results revealed no significant correlation between Galectin-3 and age, body mass index, and estimated glomerular filtration rate. Also, no significant correlation was observed between Galectin-3 levels and left ventricular ejection fraction (P = 0.166) and functional capacity (P = 0.420). Yet, a significant difference was found between males and females regarding the mean of Galectin-3 (P = 0.039).

Conclusions: The study results suggested that Galectin-3 could not be used as a marker of disease progression in the patients under treatment, which could probably be the result of medication use in these patients.

No MeSH data available.


Related in: MedlinePlus

Histogram of Normal Distribution of Galectin-3
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4302500&req=5

fig13724: Histogram of Normal Distribution of Galectin-3

Mentions: After removal of the outliers (the variables’ values greater than 3 IQR are assumed as outliers) from the data, Galectin-3 showed normal distribution and the mean Galectin-3 level was 490 ± 95 pg/mL (Figure 1). The study results revealed no significant correlation between Galectin-3 levels and age (r = 0.108, P = 0.358), Body Mass Index (BMI) (r = -0.029, P = 0.807), and estimated Glomerular Filtration Rate (eGFR) (r = -0.070, P = 0.550). The patients’ mean of BMI was 27.11 ± 4.5. Moreover, the mean of Galectin-3 was 666 ± 467 pg/mL in males and 499 ± 199 pg/mL in females and the difference was statistically significant (P = 0.039). However, no significant correlation was found between Galectin-3 levels and LVEF (P = 0.166) and FC (P = 0.420) in the HF patients.


Assessment of the Relationship between Galectin-3 and Ejection Fraction and Functional Capacity in the Patients with Compensated Systolic Heart Failure.

Atabakhshian R, Kazerouni F, Raygan F, Amirrasouli H, Rahimipour A, Shakeri N - Int Cardiovasc Res J (2014)

Histogram of Normal Distribution of Galectin-3
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4302500&req=5

fig13724: Histogram of Normal Distribution of Galectin-3
Mentions: After removal of the outliers (the variables’ values greater than 3 IQR are assumed as outliers) from the data, Galectin-3 showed normal distribution and the mean Galectin-3 level was 490 ± 95 pg/mL (Figure 1). The study results revealed no significant correlation between Galectin-3 levels and age (r = 0.108, P = 0.358), Body Mass Index (BMI) (r = -0.029, P = 0.807), and estimated Glomerular Filtration Rate (eGFR) (r = -0.070, P = 0.550). The patients’ mean of BMI was 27.11 ± 4.5. Moreover, the mean of Galectin-3 was 666 ± 467 pg/mL in males and 499 ± 199 pg/mL in females and the difference was statistically significant (P = 0.039). However, no significant correlation was found between Galectin-3 levels and LVEF (P = 0.166) and FC (P = 0.420) in the HF patients.

Bottom Line: P < 0.05 was considered as statistically significant.The results revealed no significant correlation between Galectin-3 and age, body mass index, and estimated glomerular filtration rate.Yet, a significant difference was found between males and females regarding the mean of Galectin-3 (P = 0.039).

View Article: PubMed Central - PubMed

Affiliation: Department of Laboratory Medicine, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran.

ABSTRACT

Background: Galectin-3 is a soluble ß-galactoside-binding lectin released by activated cardiac macrophages. Galectin-3 has been proposed for diagnosis and prognosis of HF patients.

Objectives: The present study aimed to investigate the relationship between galectin-3 as a biomarker and ejection fraction and functional capacity in the patients with compensated systolic heart failure.

Patients and methods: In this study, serum levels of Galectin-3 were measured in 76 patients with compensated heart failure with New York Heart Association class I-IV and left ventricular ejection fraction < 45%. Galectin-3 was measured by an ELISA kit. Besides, echocardiography was used to evaluate left ventricular ejection fraction. Additionally, functional capacity was determined based on the patients' ability to perform a set of activities. After all, the data were analyzed used t-test, Kruskal-Wallis, one-way ANOVA, and chi-square test. P < 0.05 was considered as statistically significant.

Results: The patients' age ranged from 45 to 75 years, with the mean age of 63.85 ± 9 years. In addition 57.9% of the patients were male. The results revealed no significant correlation between Galectin-3 and age, body mass index, and estimated glomerular filtration rate. Also, no significant correlation was observed between Galectin-3 levels and left ventricular ejection fraction (P = 0.166) and functional capacity (P = 0.420). Yet, a significant difference was found between males and females regarding the mean of Galectin-3 (P = 0.039).

Conclusions: The study results suggested that Galectin-3 could not be used as a marker of disease progression in the patients under treatment, which could probably be the result of medication use in these patients.

No MeSH data available.


Related in: MedlinePlus