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Early hyperbaric oxygen therapy inhibits aquaporin 4 and adrenocorticotropic hormone expression in the pituitary gland of rabbits with blast-induced craniocerebral injury.

Huo J, Liu J, Wang J, Zhang Y, Wang C, Yang Y, Sun W, Xu S - Neural Regen Res (2012)

Bottom Line: Immunohistochemistry showed significantly reduced aquaporin 4 expression and adrenocorticotropic hormone expression in the pituitary gland of rabbits with craniocerebral injury.Aquaporin 4 expression was positively correlated with adrenocorticotropic hormone expression.These findings indicate that early hyperbaric oxygen therapy may suppress adrenocorticotropic hormone secretion by inhibiting aquaporin 4 expression.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurosurgery, the 105 Hospital of Chinese PLA, Hefei 230032, Anhui Province, China.

ABSTRACT
In the present study, rabbits were treated with hyperbaric oxygen for 1 hour after detonator-blast- induced craniocerebral injury. Immunohistochemistry showed significantly reduced aquaporin 4 expression and adrenocorticotropic hormone expression in the pituitary gland of rabbits with craniocerebral injury. Aquaporin 4 expression was positively correlated with adrenocorticotropic hormone expression. These findings indicate that early hyperbaric oxygen therapy may suppress adrenocorticotropic hormone secretion by inhibiting aquaporin 4 expression.

No MeSH data available.


Related in: MedlinePlus

Co-expression of aquaporin 4 (AQP4) and adrenocorticotropic hormone (ACTH) in pituitary cells at 6 hours after blast-induced craniocerebral injury (immunohistochemical double-labeling; × 400).Arrow a shows AQP4 expression. AQP4 was mainly expressed in the membrane and cytoplasm of some cells. Arrow b shows ACTH expression. ACTH was expressed in the cytoplasm of corticotrophs. Arrow c shows AQP4 and ACTH co-expression.(A) Untreated blast injury group.(B) Hyperbaric oxygen group.
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Figure 4: Co-expression of aquaporin 4 (AQP4) and adrenocorticotropic hormone (ACTH) in pituitary cells at 6 hours after blast-induced craniocerebral injury (immunohistochemical double-labeling; × 400).Arrow a shows AQP4 expression. AQP4 was mainly expressed in the membrane and cytoplasm of some cells. Arrow b shows ACTH expression. ACTH was expressed in the cytoplasm of corticotrophs. Arrow c shows AQP4 and ACTH co-expression.(A) Untreated blast injury group.(B) Hyperbaric oxygen group.

Mentions: A number of cells co-expressing aquaporin and adrenocorticotropic hormone were observed in the adenohypophysis of the untreated blast injury group, mixed with aquaporin-positive cells and adrenocorticotropic hormone-positive cells. The number of double-labeled cells decreased significantly after hyperbaric oxygen therapy compared with that in the untreated blast injury group at 72 hours after injury (Figure 4).


Early hyperbaric oxygen therapy inhibits aquaporin 4 and adrenocorticotropic hormone expression in the pituitary gland of rabbits with blast-induced craniocerebral injury.

Huo J, Liu J, Wang J, Zhang Y, Wang C, Yang Y, Sun W, Xu S - Neural Regen Res (2012)

Co-expression of aquaporin 4 (AQP4) and adrenocorticotropic hormone (ACTH) in pituitary cells at 6 hours after blast-induced craniocerebral injury (immunohistochemical double-labeling; × 400).Arrow a shows AQP4 expression. AQP4 was mainly expressed in the membrane and cytoplasm of some cells. Arrow b shows ACTH expression. ACTH was expressed in the cytoplasm of corticotrophs. Arrow c shows AQP4 and ACTH co-expression.(A) Untreated blast injury group.(B) Hyperbaric oxygen group.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4302454&req=5

Figure 4: Co-expression of aquaporin 4 (AQP4) and adrenocorticotropic hormone (ACTH) in pituitary cells at 6 hours after blast-induced craniocerebral injury (immunohistochemical double-labeling; × 400).Arrow a shows AQP4 expression. AQP4 was mainly expressed in the membrane and cytoplasm of some cells. Arrow b shows ACTH expression. ACTH was expressed in the cytoplasm of corticotrophs. Arrow c shows AQP4 and ACTH co-expression.(A) Untreated blast injury group.(B) Hyperbaric oxygen group.
Mentions: A number of cells co-expressing aquaporin and adrenocorticotropic hormone were observed in the adenohypophysis of the untreated blast injury group, mixed with aquaporin-positive cells and adrenocorticotropic hormone-positive cells. The number of double-labeled cells decreased significantly after hyperbaric oxygen therapy compared with that in the untreated blast injury group at 72 hours after injury (Figure 4).

Bottom Line: Immunohistochemistry showed significantly reduced aquaporin 4 expression and adrenocorticotropic hormone expression in the pituitary gland of rabbits with craniocerebral injury.Aquaporin 4 expression was positively correlated with adrenocorticotropic hormone expression.These findings indicate that early hyperbaric oxygen therapy may suppress adrenocorticotropic hormone secretion by inhibiting aquaporin 4 expression.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurosurgery, the 105 Hospital of Chinese PLA, Hefei 230032, Anhui Province, China.

ABSTRACT
In the present study, rabbits were treated with hyperbaric oxygen for 1 hour after detonator-blast- induced craniocerebral injury. Immunohistochemistry showed significantly reduced aquaporin 4 expression and adrenocorticotropic hormone expression in the pituitary gland of rabbits with craniocerebral injury. Aquaporin 4 expression was positively correlated with adrenocorticotropic hormone expression. These findings indicate that early hyperbaric oxygen therapy may suppress adrenocorticotropic hormone secretion by inhibiting aquaporin 4 expression.

No MeSH data available.


Related in: MedlinePlus