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Pulmonary tumor thrombotic microangiopathy from metastatic prostate carcinoma.

Nayyar D, Muthiah K, Hayward CS, Lim Z, Granger EK, Nicholls M, Glanville AR - Case Rep Pulmonol (2015)

Bottom Line: Pulmonary tumor thrombotic microangiopathy is a rare but serious malignancy-related respiratory complication.The most common causative neoplasm is gastric adenocarcinoma.To our knowledge, this is the second reported case from metastatic prostate adenocarcinoma.

View Article: PubMed Central - PubMed

Affiliation: St. Vincent's Hospital, Victoria Street, Darlinghurst, Sydney, NSW 2010, Australia.

ABSTRACT
Pulmonary tumor thrombotic microangiopathy is a rare but serious malignancy-related respiratory complication. The most common causative neoplasm is gastric adenocarcinoma. We report a case caused by metastatic prostate adenocarcinoma, diagnosed postmortem in a 58-year-old male. To our knowledge, this is the second reported case from metastatic prostate adenocarcinoma.

No MeSH data available.


Related in: MedlinePlus

CTPA indicating subtle bilateral and diffuse bronchiolar densities with tree-in-bud appearance but no evidence of pulmonary embolism.
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fig1: CTPA indicating subtle bilateral and diffuse bronchiolar densities with tree-in-bud appearance but no evidence of pulmonary embolism.

Mentions: Full blood count and blood chemistry were normal. Arterial blood gas measurement revealed hypoxemia with chronic respiratory alkalosis (pH 7.45, pO2 37 mmHg, pCO2 22 mmHg). Electrocardiogram showed sinus tachycardia. Chest radiograph indicated clear lung fields and mild cardiomegaly. Transthoracic echocardiogram revealed severe pulmonary hypertension (pulmonary artery pressure 90 mmHg) and right ventricular dilatation with impaired right ventricular systolic function. Left ventricular size and systolic function were normal. Computed tomography pulmonary angiogram (CTPA) revealed subtle bilateral and diffuse bronchiolar densities with tree-in-bud appearance but no evidence of pulmonary embolism (Figure 1). A ventilation-perfusion (V/Q) scan was not performed. Pulmonary function testing was normal.


Pulmonary tumor thrombotic microangiopathy from metastatic prostate carcinoma.

Nayyar D, Muthiah K, Hayward CS, Lim Z, Granger EK, Nicholls M, Glanville AR - Case Rep Pulmonol (2015)

CTPA indicating subtle bilateral and diffuse bronchiolar densities with tree-in-bud appearance but no evidence of pulmonary embolism.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4302364&req=5

fig1: CTPA indicating subtle bilateral and diffuse bronchiolar densities with tree-in-bud appearance but no evidence of pulmonary embolism.
Mentions: Full blood count and blood chemistry were normal. Arterial blood gas measurement revealed hypoxemia with chronic respiratory alkalosis (pH 7.45, pO2 37 mmHg, pCO2 22 mmHg). Electrocardiogram showed sinus tachycardia. Chest radiograph indicated clear lung fields and mild cardiomegaly. Transthoracic echocardiogram revealed severe pulmonary hypertension (pulmonary artery pressure 90 mmHg) and right ventricular dilatation with impaired right ventricular systolic function. Left ventricular size and systolic function were normal. Computed tomography pulmonary angiogram (CTPA) revealed subtle bilateral and diffuse bronchiolar densities with tree-in-bud appearance but no evidence of pulmonary embolism (Figure 1). A ventilation-perfusion (V/Q) scan was not performed. Pulmonary function testing was normal.

Bottom Line: Pulmonary tumor thrombotic microangiopathy is a rare but serious malignancy-related respiratory complication.The most common causative neoplasm is gastric adenocarcinoma.To our knowledge, this is the second reported case from metastatic prostate adenocarcinoma.

View Article: PubMed Central - PubMed

Affiliation: St. Vincent's Hospital, Victoria Street, Darlinghurst, Sydney, NSW 2010, Australia.

ABSTRACT
Pulmonary tumor thrombotic microangiopathy is a rare but serious malignancy-related respiratory complication. The most common causative neoplasm is gastric adenocarcinoma. We report a case caused by metastatic prostate adenocarcinoma, diagnosed postmortem in a 58-year-old male. To our knowledge, this is the second reported case from metastatic prostate adenocarcinoma.

No MeSH data available.


Related in: MedlinePlus