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Pharmacokinetic interactions of herbs with cytochrome p450 and p-glycoprotein.

Cho HJ, Yoon IS - Evid Based Complement Alternat Med (2015)

Bottom Line: The concurrent use of drugs and herbal products is becoming increasingly prevalent over the last decade.Several herbal products have been known to modulate cytochrome P450 (CYP) enzymes and P-glycoprotein (P-gp) which are recognized as representative drug metabolizing enzymes and drug transporter, respectively.The main focus is placed on previous works on the ability of herbal extracts and their phytochemicals to modulate the expression and function of CYP and P-gp in several in vitro and in vivo animal and human systems.

View Article: PubMed Central - PubMed

Affiliation: College of Pharmacy, Kangwon National University, Chuncheon 200-701, Republic of Korea.

ABSTRACT
The concurrent use of drugs and herbal products is becoming increasingly prevalent over the last decade. Several herbal products have been known to modulate cytochrome P450 (CYP) enzymes and P-glycoprotein (P-gp) which are recognized as representative drug metabolizing enzymes and drug transporter, respectively. Thus, a summary of knowledge on the modulation of CYP and P-gp by commonly used herbs can provide robust fundamentals for optimizing CYP and/or P-gp substrate drug-based therapy. Herein, we review ten popular medicinal and/or dietary herbs as perpetrators of CYP- and P-gp-mediated pharmacokinetic herb-drug interactions. The main focus is placed on previous works on the ability of herbal extracts and their phytochemicals to modulate the expression and function of CYP and P-gp in several in vitro and in vivo animal and human systems.

No MeSH data available.


Related in: MedlinePlus

Chemical structures of rosmarinic acid (a) and curcumin (b).
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Related In: Results  -  Collection


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fig5: Chemical structures of rosmarinic acid (a) and curcumin (b).

Mentions: Rosmarinus officinalis (rosemary) has been used as a dietary herb for beverage, flavouring food, and cosmetics and as a medicinal herb for stimulant, antirheumatic, diuretic, analgesic, antiepileptic, and cancer prevention [76]. The main active component of rosemary is rosmarinic acid (Figure 5(a)) [77]. The effect of rosemary and its main active component on the expression and activity of CYP and P-gp is listed in Table 4. Oral treatment with rosemary extract increased the protein expression of hepatic CYP2B1/2, while it did not change hepatic CYP1A1/2 in rats [78]. Moreover, rosemary extract inhibited P-gp-mediated efflux of doxorubicin and vinblastine in P-gp-overexpressing MCF-7 cells [79]. Rosmarinic acid induced the in vitro activity of CYP1A, 2B, and 3A in rat HepG2/C3A and MH1C1 cells [80]. However, it inhibited human recombinant CYP3A4 activity, but not CYP2C9 and 2D6 activities [81]. It reduced the mRNA and protein expression of P-gp and also inhibited P-gp-mediated efflux of doxorubicin and rhodamine 123 in SGC7901/Adr cells [82].


Pharmacokinetic interactions of herbs with cytochrome p450 and p-glycoprotein.

Cho HJ, Yoon IS - Evid Based Complement Alternat Med (2015)

Chemical structures of rosmarinic acid (a) and curcumin (b).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4302358&req=5

fig5: Chemical structures of rosmarinic acid (a) and curcumin (b).
Mentions: Rosmarinus officinalis (rosemary) has been used as a dietary herb for beverage, flavouring food, and cosmetics and as a medicinal herb for stimulant, antirheumatic, diuretic, analgesic, antiepileptic, and cancer prevention [76]. The main active component of rosemary is rosmarinic acid (Figure 5(a)) [77]. The effect of rosemary and its main active component on the expression and activity of CYP and P-gp is listed in Table 4. Oral treatment with rosemary extract increased the protein expression of hepatic CYP2B1/2, while it did not change hepatic CYP1A1/2 in rats [78]. Moreover, rosemary extract inhibited P-gp-mediated efflux of doxorubicin and vinblastine in P-gp-overexpressing MCF-7 cells [79]. Rosmarinic acid induced the in vitro activity of CYP1A, 2B, and 3A in rat HepG2/C3A and MH1C1 cells [80]. However, it inhibited human recombinant CYP3A4 activity, but not CYP2C9 and 2D6 activities [81]. It reduced the mRNA and protein expression of P-gp and also inhibited P-gp-mediated efflux of doxorubicin and rhodamine 123 in SGC7901/Adr cells [82].

Bottom Line: The concurrent use of drugs and herbal products is becoming increasingly prevalent over the last decade.Several herbal products have been known to modulate cytochrome P450 (CYP) enzymes and P-glycoprotein (P-gp) which are recognized as representative drug metabolizing enzymes and drug transporter, respectively.The main focus is placed on previous works on the ability of herbal extracts and their phytochemicals to modulate the expression and function of CYP and P-gp in several in vitro and in vivo animal and human systems.

View Article: PubMed Central - PubMed

Affiliation: College of Pharmacy, Kangwon National University, Chuncheon 200-701, Republic of Korea.

ABSTRACT
The concurrent use of drugs and herbal products is becoming increasingly prevalent over the last decade. Several herbal products have been known to modulate cytochrome P450 (CYP) enzymes and P-glycoprotein (P-gp) which are recognized as representative drug metabolizing enzymes and drug transporter, respectively. Thus, a summary of knowledge on the modulation of CYP and P-gp by commonly used herbs can provide robust fundamentals for optimizing CYP and/or P-gp substrate drug-based therapy. Herein, we review ten popular medicinal and/or dietary herbs as perpetrators of CYP- and P-gp-mediated pharmacokinetic herb-drug interactions. The main focus is placed on previous works on the ability of herbal extracts and their phytochemicals to modulate the expression and function of CYP and P-gp in several in vitro and in vivo animal and human systems.

No MeSH data available.


Related in: MedlinePlus