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Prevalence of Precancerous Conditions and Gastric Cancer Based upon the National Cancer Screening Program in Korea for 7 Years, Single Center Experience.

Kang JH, Lim YJ, Kang JH, Yang JN, Shin SM, Choi JH, Lee JH - Gastroenterol Res Pract (2015)

Bottom Line: The prevalence of metaplastic gastritis, peptic ulcer, adenoma, EGC, and AGC was significantly higher in men than in women.The prevalence of preneoplastic/neoplastic disease significantly increased with age.Through the NCSP, the early detection of gastric cancer might contribute to the decreased mortality rate due to gastric cancer in Korea.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Dongguk University Ilsan Hospital, Dongguk University College of Medicine, 27 Dongguk-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do 410-773, Republic of Korea.

ABSTRACT
Aims. Gastric cancer is the second most prevalent cancer and the third leading cause of cancer-related deaths in Korea. The National Cancer Screening Program (NCSP) has implemented esophagogastroduodenoscopy (EGD) biennially for all Koreans starting in their 40s. This study was conducted to estimate the clinical relevance of NCSP through identifying the prevalence of gastric disease, including cancer. Materials and Methods. Data from 40,821 subjects who received the screening EGD in the single center for 7 years were retrospectively investigated. Results. The overall prevalence of nonatrophic/atrophic/metaplastic gastritis, peptic ulcer, adenoma, early gastric cancer (EGC), and advanced gastric cancer (AGC) was 44.28%, 27.97%, 14.95%, 0.59%, 0.43%, 0.21%, and 0.09%, respectively. The prevalence of metaplastic gastritis, peptic ulcer, adenoma, EGC, and AGC was significantly higher in men than in women. The prevalence of preneoplastic/neoplastic disease significantly increased with age. Judged from the ratio of EGC to AGC, the proportion of EGC made up to 70% of all cancers. Conclusions. Screening endoscopy starting for people in their 40s should be strongly recommended for the elderly. Through the NCSP, the early detection of gastric cancer might contribute to the decreased mortality rate due to gastric cancer in Korea.

No MeSH data available.


Related in: MedlinePlus

Proportion of early gastric cancer and advanced gastric cancer according to screening interval for gastric cancer. EGD: esophagogastroduodenoscopy; EGC: early gastric cancer; AGC: advanced gastric cancer.
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fig4: Proportion of early gastric cancer and advanced gastric cancer according to screening interval for gastric cancer. EGD: esophagogastroduodenoscopy; EGC: early gastric cancer; AGC: advanced gastric cancer.

Mentions: A 10-year study of the natural progression of EGC reported that 64.28% (36/56) of the patients progressed to AGC [20, 21]. Determining the proper screening interval is important. All the gastric cancer patients who underwent EGD every 2 years were confirmed to have had EGC and displayed a 5-year survival rate of 96.5%, which was significantly greater than the 71.0% in the EGD group that underwent EGD less frequently [22]. No significant difference in the EGC/AGC ratio was observed between subjects receiving EGD within 2-year interval than every 2 years and every 2 or more years (88.9% versus 83.3%), but the ratios that could be endoscopically treated were 29.6% (8/27) and 0% (0/12), respectively (P = 0.0344) [23]. EGC was observed in 96% (25/26) of the patients who underwent screening EGD within 2 years, whereas only 71% (34/48) of the patients who undergo the screening EGD at more than 2 years were confirmed to have EGC (P = 0.01) [24]. In the present study, of the subjects who were diagnosed with gastric cancer, 12 patients underwent EGD more than twice before the diagnosis. Of those 12, 8 underwent EGD within 2 years: one was diagnosed with AGC and seven were diagnosed with EGC. Of the other 4 subjects who underwent EGD less than once every 2 years before they were diagnosed as gastric cancer, one was diagnosed with EGC and three were diagnosed with AGC (Figure 4). Gastric cancer patients who underwent EGD less than once every 2 years have favorable prognosis. In high-risk examinees diagnosed with a precancerous lesion in their EGD or who had symptoms or a family history of gastric cancer, it may be necessary to have an EGD which may be necessary more than once every 2 years.


Prevalence of Precancerous Conditions and Gastric Cancer Based upon the National Cancer Screening Program in Korea for 7 Years, Single Center Experience.

Kang JH, Lim YJ, Kang JH, Yang JN, Shin SM, Choi JH, Lee JH - Gastroenterol Res Pract (2015)

Proportion of early gastric cancer and advanced gastric cancer according to screening interval for gastric cancer. EGD: esophagogastroduodenoscopy; EGC: early gastric cancer; AGC: advanced gastric cancer.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4302356&req=5

fig4: Proportion of early gastric cancer and advanced gastric cancer according to screening interval for gastric cancer. EGD: esophagogastroduodenoscopy; EGC: early gastric cancer; AGC: advanced gastric cancer.
Mentions: A 10-year study of the natural progression of EGC reported that 64.28% (36/56) of the patients progressed to AGC [20, 21]. Determining the proper screening interval is important. All the gastric cancer patients who underwent EGD every 2 years were confirmed to have had EGC and displayed a 5-year survival rate of 96.5%, which was significantly greater than the 71.0% in the EGD group that underwent EGD less frequently [22]. No significant difference in the EGC/AGC ratio was observed between subjects receiving EGD within 2-year interval than every 2 years and every 2 or more years (88.9% versus 83.3%), but the ratios that could be endoscopically treated were 29.6% (8/27) and 0% (0/12), respectively (P = 0.0344) [23]. EGC was observed in 96% (25/26) of the patients who underwent screening EGD within 2 years, whereas only 71% (34/48) of the patients who undergo the screening EGD at more than 2 years were confirmed to have EGC (P = 0.01) [24]. In the present study, of the subjects who were diagnosed with gastric cancer, 12 patients underwent EGD more than twice before the diagnosis. Of those 12, 8 underwent EGD within 2 years: one was diagnosed with AGC and seven were diagnosed with EGC. Of the other 4 subjects who underwent EGD less than once every 2 years before they were diagnosed as gastric cancer, one was diagnosed with EGC and three were diagnosed with AGC (Figure 4). Gastric cancer patients who underwent EGD less than once every 2 years have favorable prognosis. In high-risk examinees diagnosed with a precancerous lesion in their EGD or who had symptoms or a family history of gastric cancer, it may be necessary to have an EGD which may be necessary more than once every 2 years.

Bottom Line: The prevalence of metaplastic gastritis, peptic ulcer, adenoma, EGC, and AGC was significantly higher in men than in women.The prevalence of preneoplastic/neoplastic disease significantly increased with age.Through the NCSP, the early detection of gastric cancer might contribute to the decreased mortality rate due to gastric cancer in Korea.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Dongguk University Ilsan Hospital, Dongguk University College of Medicine, 27 Dongguk-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do 410-773, Republic of Korea.

ABSTRACT
Aims. Gastric cancer is the second most prevalent cancer and the third leading cause of cancer-related deaths in Korea. The National Cancer Screening Program (NCSP) has implemented esophagogastroduodenoscopy (EGD) biennially for all Koreans starting in their 40s. This study was conducted to estimate the clinical relevance of NCSP through identifying the prevalence of gastric disease, including cancer. Materials and Methods. Data from 40,821 subjects who received the screening EGD in the single center for 7 years were retrospectively investigated. Results. The overall prevalence of nonatrophic/atrophic/metaplastic gastritis, peptic ulcer, adenoma, early gastric cancer (EGC), and advanced gastric cancer (AGC) was 44.28%, 27.97%, 14.95%, 0.59%, 0.43%, 0.21%, and 0.09%, respectively. The prevalence of metaplastic gastritis, peptic ulcer, adenoma, EGC, and AGC was significantly higher in men than in women. The prevalence of preneoplastic/neoplastic disease significantly increased with age. Judged from the ratio of EGC to AGC, the proportion of EGC made up to 70% of all cancers. Conclusions. Screening endoscopy starting for people in their 40s should be strongly recommended for the elderly. Through the NCSP, the early detection of gastric cancer might contribute to the decreased mortality rate due to gastric cancer in Korea.

No MeSH data available.


Related in: MedlinePlus