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Prevalence of Precancerous Conditions and Gastric Cancer Based upon the National Cancer Screening Program in Korea for 7 Years, Single Center Experience.

Kang JH, Lim YJ, Kang JH, Yang JN, Shin SM, Choi JH, Lee JH - Gastroenterol Res Pract (2015)

Bottom Line: The prevalence of metaplastic gastritis, peptic ulcer, adenoma, EGC, and AGC was significantly higher in men than in women.The prevalence of preneoplastic/neoplastic disease significantly increased with age.Through the NCSP, the early detection of gastric cancer might contribute to the decreased mortality rate due to gastric cancer in Korea.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Dongguk University Ilsan Hospital, Dongguk University College of Medicine, 27 Dongguk-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do 410-773, Republic of Korea.

ABSTRACT
Aims. Gastric cancer is the second most prevalent cancer and the third leading cause of cancer-related deaths in Korea. The National Cancer Screening Program (NCSP) has implemented esophagogastroduodenoscopy (EGD) biennially for all Koreans starting in their 40s. This study was conducted to estimate the clinical relevance of NCSP through identifying the prevalence of gastric disease, including cancer. Materials and Methods. Data from 40,821 subjects who received the screening EGD in the single center for 7 years were retrospectively investigated. Results. The overall prevalence of nonatrophic/atrophic/metaplastic gastritis, peptic ulcer, adenoma, early gastric cancer (EGC), and advanced gastric cancer (AGC) was 44.28%, 27.97%, 14.95%, 0.59%, 0.43%, 0.21%, and 0.09%, respectively. The prevalence of metaplastic gastritis, peptic ulcer, adenoma, EGC, and AGC was significantly higher in men than in women. The prevalence of preneoplastic/neoplastic disease significantly increased with age. Judged from the ratio of EGC to AGC, the proportion of EGC made up to 70% of all cancers. Conclusions. Screening endoscopy starting for people in their 40s should be strongly recommended for the elderly. Through the NCSP, the early detection of gastric cancer might contribute to the decreased mortality rate due to gastric cancer in Korea.

No MeSH data available.


Related in: MedlinePlus

Overall prevalence of gastric diseases. EGC: early gastric cancer; AGC: advanced gastric cancer; PUD: peptic ulcer disease.
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Related In: Results  -  Collection


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fig1: Overall prevalence of gastric diseases. EGC: early gastric cancer; AGC: advanced gastric cancer; PUD: peptic ulcer disease.

Mentions: Of the 40,821 examinees, 17,807 (43.62%) were men and 23,014 (56.38%) were women. The subjects ranged in age from 40 years to 93 years, with a mean age of 56.23 ± 9.76 years (Table 1). Regarding the prevalence of gastric diseases, 18,076 people (44.28%) had nonatrophic gastritis, 11,419 (27.97%) had atrophic gastritis, 6,102 (14.95%) had metaplastic gastritis, 175 (0.43%) had adenoma, 86 (0.21%) had EGC, 37 (0.09%) had AGC, and 241 (0.59%) had peptic ulcers. Among peptic ulcers, 102 people (0.25%) had gastric ulcers, 96 (0.24%) had duodenal ulcers, and 43 (0.1%) had both gastric ulcers and duodenal ulcers (Figure 1). Women made up the majority of nonatrophic and atrophic gastritis cases, while more men had metaplastic gastritis, adenomas, EGC, and AGC. Endoscopy showed that normal gastric mucosa decreased as people aged, while nonatrophic gastritis did not remarkably change in age groups. The prevalence of atrophic and metaplastic gastritis increased in people 70 years and over but decreased in people over 80 years. Adenoma and gastric cancer increased in older subjects, with highest prevalence in subjects in their 80s.


Prevalence of Precancerous Conditions and Gastric Cancer Based upon the National Cancer Screening Program in Korea for 7 Years, Single Center Experience.

Kang JH, Lim YJ, Kang JH, Yang JN, Shin SM, Choi JH, Lee JH - Gastroenterol Res Pract (2015)

Overall prevalence of gastric diseases. EGC: early gastric cancer; AGC: advanced gastric cancer; PUD: peptic ulcer disease.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4302356&req=5

fig1: Overall prevalence of gastric diseases. EGC: early gastric cancer; AGC: advanced gastric cancer; PUD: peptic ulcer disease.
Mentions: Of the 40,821 examinees, 17,807 (43.62%) were men and 23,014 (56.38%) were women. The subjects ranged in age from 40 years to 93 years, with a mean age of 56.23 ± 9.76 years (Table 1). Regarding the prevalence of gastric diseases, 18,076 people (44.28%) had nonatrophic gastritis, 11,419 (27.97%) had atrophic gastritis, 6,102 (14.95%) had metaplastic gastritis, 175 (0.43%) had adenoma, 86 (0.21%) had EGC, 37 (0.09%) had AGC, and 241 (0.59%) had peptic ulcers. Among peptic ulcers, 102 people (0.25%) had gastric ulcers, 96 (0.24%) had duodenal ulcers, and 43 (0.1%) had both gastric ulcers and duodenal ulcers (Figure 1). Women made up the majority of nonatrophic and atrophic gastritis cases, while more men had metaplastic gastritis, adenomas, EGC, and AGC. Endoscopy showed that normal gastric mucosa decreased as people aged, while nonatrophic gastritis did not remarkably change in age groups. The prevalence of atrophic and metaplastic gastritis increased in people 70 years and over but decreased in people over 80 years. Adenoma and gastric cancer increased in older subjects, with highest prevalence in subjects in their 80s.

Bottom Line: The prevalence of metaplastic gastritis, peptic ulcer, adenoma, EGC, and AGC was significantly higher in men than in women.The prevalence of preneoplastic/neoplastic disease significantly increased with age.Through the NCSP, the early detection of gastric cancer might contribute to the decreased mortality rate due to gastric cancer in Korea.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Dongguk University Ilsan Hospital, Dongguk University College of Medicine, 27 Dongguk-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do 410-773, Republic of Korea.

ABSTRACT
Aims. Gastric cancer is the second most prevalent cancer and the third leading cause of cancer-related deaths in Korea. The National Cancer Screening Program (NCSP) has implemented esophagogastroduodenoscopy (EGD) biennially for all Koreans starting in their 40s. This study was conducted to estimate the clinical relevance of NCSP through identifying the prevalence of gastric disease, including cancer. Materials and Methods. Data from 40,821 subjects who received the screening EGD in the single center for 7 years were retrospectively investigated. Results. The overall prevalence of nonatrophic/atrophic/metaplastic gastritis, peptic ulcer, adenoma, early gastric cancer (EGC), and advanced gastric cancer (AGC) was 44.28%, 27.97%, 14.95%, 0.59%, 0.43%, 0.21%, and 0.09%, respectively. The prevalence of metaplastic gastritis, peptic ulcer, adenoma, EGC, and AGC was significantly higher in men than in women. The prevalence of preneoplastic/neoplastic disease significantly increased with age. Judged from the ratio of EGC to AGC, the proportion of EGC made up to 70% of all cancers. Conclusions. Screening endoscopy starting for people in their 40s should be strongly recommended for the elderly. Through the NCSP, the early detection of gastric cancer might contribute to the decreased mortality rate due to gastric cancer in Korea.

No MeSH data available.


Related in: MedlinePlus