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Solitary fibrous tumor of the submandibular region.

Shi W, Wei Z - Oncol Lett (2014)

Bottom Line: A computed tomography scan demonstrated the presence of a well-defined, slightly low-density nodular shadow measuring 2.6×3.3×3.8 cm, in proximity to the right submandibular gland, with mild contrast enhancement and no association with the adjacent lymph nodes.The patient has so far been followed up for 22 months, with no signs of recurrence or metastases.The study proposes that, although rare, SFTs of the submandibular region should be included in the differential diagnosis of soft-tissue tumors in the submandibular region.

View Article: PubMed Central - PubMed

Affiliation: Department of Stomatology, The Third Central Hospital, Tianjin 300170, P.R. China.

ABSTRACT

Solitary fibrous tumors (SFTs) are a rare type of neoplasm that originate from the pleura. Although SFTs may occur in a variety of extrathoracic regions, they are considered to be rare in the submandibular region. The current study presents the case of a 39-year-old female with a 3×4-cm, fibro-elastic, movable, painless nodule in the right side of the submandibular region. The patient exhibited no other clinical manifestations in the head and neck region. A computed tomography scan demonstrated the presence of a well-defined, slightly low-density nodular shadow measuring 2.6×3.3×3.8 cm, in proximity to the right submandibular gland, with mild contrast enhancement and no association with the adjacent lymph nodes. The lesion was surgically excised, and following histopathological and immunohistochemical analysis, immunohistochemical staining determined that the lesion was positive for cluster of differentiation (CD)34, CD99 and vimentin, and negative for desmin, CD31 and S-100; therefore, a diagnosis of an SFT was determined. The patient has so far been followed up for 22 months, with no signs of recurrence or metastases. The present study also discusses the clinical, histopathological and immunohistochemical features, treatment strategies and potential clinical outcomes of SFTs. The study proposes that, although rare, SFTs of the submandibular region should be included in the differential diagnosis of soft-tissue tumors in the submandibular region.

No MeSH data available.


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Computed tomography scan of a soft-tissue mass located adjacent to the right submandibular gland.
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f1-ol-09-02-0984: Computed tomography scan of a soft-tissue mass located adjacent to the right submandibular gland.

Mentions: In April 2012, a 39-year-old female patient presented to The Third Central Hospital (Tianjin, China) with a one-week history of a progressively enlarging, painless nodule in the right side of the submandibular region. The patient exhibited no other clinical manifestations in the head and neck region, and no symptoms, such as fever, dyspnea, odynophagia, night sweats or weight loss. No significant personal or family medical history was noted and the patient had no history of tobacco or alcohol use. A physical examination revealed a 3×4-cm, fibro-elastic, movable, non-tender mass in the right submandibular triangle, however, no cervical lymphadenopathy was identified and the laboratory data was unremarkable. A computed tomography scan identified the presence of a well-defined, marginally low-density nodular shadow measuring 2.6×3.3×3.8 cm, in proximity to the right submandibular gland, with mild contrast enhancement and no associated adjacent lymph nodes (Fig. 1). Extirpation of the tumor was performed under general anesthesia. During the surgical procedure, a well-demarcated mass was identified; the tumor was well-circumscribed and did not involve the submandibular gland, therefore, it could be removed easily. The post-operative recovery was uneventful. The surgical specimen was a 2.2×3.0×3.5-cm soft-tissue mass that was gray-white in color, oval-shaped and firm in consistency. Microscopically, the lesion consisted of spindle-shaped cells with scant cytoplasm accompanied by prominent hyalinized collagenous tissue, which displayed hemangiopericytomatous patterns. The cells did not display cytological atypia and no mitotic figures were detected. In addition, immunohistochemical staining was positive for CD34, CD99 and vimentin, and negative for desmin, CD31 and S-100 (Fig. 1); these histopathological and immunohistochemical findings were used to determine a diagnosis of an SFT. The patient has so far been followed up for 22 months, with no signs of recurrence or metastases.


Solitary fibrous tumor of the submandibular region.

Shi W, Wei Z - Oncol Lett (2014)

Computed tomography scan of a soft-tissue mass located adjacent to the right submandibular gland.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4301507&req=5

f1-ol-09-02-0984: Computed tomography scan of a soft-tissue mass located adjacent to the right submandibular gland.
Mentions: In April 2012, a 39-year-old female patient presented to The Third Central Hospital (Tianjin, China) with a one-week history of a progressively enlarging, painless nodule in the right side of the submandibular region. The patient exhibited no other clinical manifestations in the head and neck region, and no symptoms, such as fever, dyspnea, odynophagia, night sweats or weight loss. No significant personal or family medical history was noted and the patient had no history of tobacco or alcohol use. A physical examination revealed a 3×4-cm, fibro-elastic, movable, non-tender mass in the right submandibular triangle, however, no cervical lymphadenopathy was identified and the laboratory data was unremarkable. A computed tomography scan identified the presence of a well-defined, marginally low-density nodular shadow measuring 2.6×3.3×3.8 cm, in proximity to the right submandibular gland, with mild contrast enhancement and no associated adjacent lymph nodes (Fig. 1). Extirpation of the tumor was performed under general anesthesia. During the surgical procedure, a well-demarcated mass was identified; the tumor was well-circumscribed and did not involve the submandibular gland, therefore, it could be removed easily. The post-operative recovery was uneventful. The surgical specimen was a 2.2×3.0×3.5-cm soft-tissue mass that was gray-white in color, oval-shaped and firm in consistency. Microscopically, the lesion consisted of spindle-shaped cells with scant cytoplasm accompanied by prominent hyalinized collagenous tissue, which displayed hemangiopericytomatous patterns. The cells did not display cytological atypia and no mitotic figures were detected. In addition, immunohistochemical staining was positive for CD34, CD99 and vimentin, and negative for desmin, CD31 and S-100 (Fig. 1); these histopathological and immunohistochemical findings were used to determine a diagnosis of an SFT. The patient has so far been followed up for 22 months, with no signs of recurrence or metastases.

Bottom Line: A computed tomography scan demonstrated the presence of a well-defined, slightly low-density nodular shadow measuring 2.6×3.3×3.8 cm, in proximity to the right submandibular gland, with mild contrast enhancement and no association with the adjacent lymph nodes.The patient has so far been followed up for 22 months, with no signs of recurrence or metastases.The study proposes that, although rare, SFTs of the submandibular region should be included in the differential diagnosis of soft-tissue tumors in the submandibular region.

View Article: PubMed Central - PubMed

Affiliation: Department of Stomatology, The Third Central Hospital, Tianjin 300170, P.R. China.

ABSTRACT

Solitary fibrous tumors (SFTs) are a rare type of neoplasm that originate from the pleura. Although SFTs may occur in a variety of extrathoracic regions, they are considered to be rare in the submandibular region. The current study presents the case of a 39-year-old female with a 3×4-cm, fibro-elastic, movable, painless nodule in the right side of the submandibular region. The patient exhibited no other clinical manifestations in the head and neck region. A computed tomography scan demonstrated the presence of a well-defined, slightly low-density nodular shadow measuring 2.6×3.3×3.8 cm, in proximity to the right submandibular gland, with mild contrast enhancement and no association with the adjacent lymph nodes. The lesion was surgically excised, and following histopathological and immunohistochemical analysis, immunohistochemical staining determined that the lesion was positive for cluster of differentiation (CD)34, CD99 and vimentin, and negative for desmin, CD31 and S-100; therefore, a diagnosis of an SFT was determined. The patient has so far been followed up for 22 months, with no signs of recurrence or metastases. The present study also discusses the clinical, histopathological and immunohistochemical features, treatment strategies and potential clinical outcomes of SFTs. The study proposes that, although rare, SFTs of the submandibular region should be included in the differential diagnosis of soft-tissue tumors in the submandibular region.

No MeSH data available.


Related in: MedlinePlus