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Expression and significance of glucose transporter-1, P-glycoprotein, multidrug resistance-associated protein and glutathione S-transferase-π in laryngeal carcinoma.

Mao ZP, Zhao LJ, Zhou SH, Liu MQ, Tan WF, Yao HT - Oncol Lett (2014)

Bottom Line: GLUT-1 expression was found to significantly correlate with tumor-node-metastasis classification (P=0.02) and clinical stage (P=0.037).Furthermore, P-gp was found to significantly correlate with clinical stage (P=0.026).P-gp was found to significantly correlate with clinical stage, while MRP1 overexpression was significantly associated with poor survival.

View Article: PubMed Central - PubMed

Affiliation: Department of Otolaryngology, The Second Hospital of Shaoxing City, Shaoxing, Zhejiang 312000, P.R. China.

ABSTRACT

Increasing glucose transporter-1 (GLUT-1) activity is one of the most important ways to increase the cellular influx of glucose. We previously demonstrated that increased GLUT-1 expression was an independent predictor of survival in patients with laryngeal carcinoma. Thus, GLUT-1 may present a novel therapeutic target in laryngeal carcinoma. In this study, the expression of GLUT-1, P-glycoprotein (P-gp), multidrug resistance-associated protein 1 (MRP1) and glutathione S-transferase-π (GST-π) in laryngeal carcinomas was investigated by immunohistochemistry. Additionally, possible correlations between GLUT-1 and P-gp, MRP1 and GST-π and various clinicopathological parameters were analyzed. In this study, 52.9% (18/34), 58.8% (20/34), 20.6% (7/34) and 58.8% (20/34) of the laryngeal carcinomas were positive for GLUT-1, P-gp, MRP1 and GST-π, respectively. The expression of GLUT-1, P-gp, MRP1 and GST-π was higher in laryngeal carcinoma specimens when compared with laryngeal precancerous lesions (P<0.05). Pearson's correlation analysis showed correlations between GLUT-1 and P-gp (r=0.364; P=0.034), GLUT-1 and MRP1 (r=0.359; P=0.037) and P-gp and GST-π (r=0.426; P=0.012). GLUT-1 expression was found to significantly correlate with tumor-node-metastasis classification (P=0.02) and clinical stage (P=0.037). Furthermore, P-gp was found to significantly correlate with clinical stage (P=0.026). Univariate analysis showed that MRP1 expression was significantly associated with poor survival (c(2)=5.16; P=0.023). Multivariate analysis revealed that lymph node metastasis (P=0.009) and MRP1 overexpression (P=0.023) were significant predictors of poor survival. In the present study, the expression of GLUT-1, P-gp, MRP1 and GST-π in laryngeal carcinomas was investigated, as well as the correlations between these proteins. P-gp was found to significantly correlate with clinical stage, while MRP1 overexpression was significantly associated with poor survival.

No MeSH data available.


Related in: MedlinePlus

Univariate analysis shows that MRP1-positivity is significantly associated with poorer survival (χ2=5.16; P=0.023). MRP1, multidrug resistance-associated protein 1.
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f2-ol-09-02-0806: Univariate analysis shows that MRP1-positivity is significantly associated with poorer survival (χ2=5.16; P=0.023). MRP1, multidrug resistance-associated protein 1.

Mentions: Univariate analysis showed that MRP1 expression was significantly associated with reduced survival (χ2=5.16; P=0.023; Fig. 2). By contrast, GLUT-1, P-gp and GST-π expression were not associated with survival. Multivariate analysis revealed that lymph node metastasis (P=0.009) and MRP1 overexpression (P=0.023) were significant predictors of poor survival.


Expression and significance of glucose transporter-1, P-glycoprotein, multidrug resistance-associated protein and glutathione S-transferase-π in laryngeal carcinoma.

Mao ZP, Zhao LJ, Zhou SH, Liu MQ, Tan WF, Yao HT - Oncol Lett (2014)

Univariate analysis shows that MRP1-positivity is significantly associated with poorer survival (χ2=5.16; P=0.023). MRP1, multidrug resistance-associated protein 1.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4301491&req=5

f2-ol-09-02-0806: Univariate analysis shows that MRP1-positivity is significantly associated with poorer survival (χ2=5.16; P=0.023). MRP1, multidrug resistance-associated protein 1.
Mentions: Univariate analysis showed that MRP1 expression was significantly associated with reduced survival (χ2=5.16; P=0.023; Fig. 2). By contrast, GLUT-1, P-gp and GST-π expression were not associated with survival. Multivariate analysis revealed that lymph node metastasis (P=0.009) and MRP1 overexpression (P=0.023) were significant predictors of poor survival.

Bottom Line: GLUT-1 expression was found to significantly correlate with tumor-node-metastasis classification (P=0.02) and clinical stage (P=0.037).Furthermore, P-gp was found to significantly correlate with clinical stage (P=0.026).P-gp was found to significantly correlate with clinical stage, while MRP1 overexpression was significantly associated with poor survival.

View Article: PubMed Central - PubMed

Affiliation: Department of Otolaryngology, The Second Hospital of Shaoxing City, Shaoxing, Zhejiang 312000, P.R. China.

ABSTRACT

Increasing glucose transporter-1 (GLUT-1) activity is one of the most important ways to increase the cellular influx of glucose. We previously demonstrated that increased GLUT-1 expression was an independent predictor of survival in patients with laryngeal carcinoma. Thus, GLUT-1 may present a novel therapeutic target in laryngeal carcinoma. In this study, the expression of GLUT-1, P-glycoprotein (P-gp), multidrug resistance-associated protein 1 (MRP1) and glutathione S-transferase-π (GST-π) in laryngeal carcinomas was investigated by immunohistochemistry. Additionally, possible correlations between GLUT-1 and P-gp, MRP1 and GST-π and various clinicopathological parameters were analyzed. In this study, 52.9% (18/34), 58.8% (20/34), 20.6% (7/34) and 58.8% (20/34) of the laryngeal carcinomas were positive for GLUT-1, P-gp, MRP1 and GST-π, respectively. The expression of GLUT-1, P-gp, MRP1 and GST-π was higher in laryngeal carcinoma specimens when compared with laryngeal precancerous lesions (P<0.05). Pearson's correlation analysis showed correlations between GLUT-1 and P-gp (r=0.364; P=0.034), GLUT-1 and MRP1 (r=0.359; P=0.037) and P-gp and GST-π (r=0.426; P=0.012). GLUT-1 expression was found to significantly correlate with tumor-node-metastasis classification (P=0.02) and clinical stage (P=0.037). Furthermore, P-gp was found to significantly correlate with clinical stage (P=0.026). Univariate analysis showed that MRP1 expression was significantly associated with poor survival (c(2)=5.16; P=0.023). Multivariate analysis revealed that lymph node metastasis (P=0.009) and MRP1 overexpression (P=0.023) were significant predictors of poor survival. In the present study, the expression of GLUT-1, P-gp, MRP1 and GST-π in laryngeal carcinomas was investigated, as well as the correlations between these proteins. P-gp was found to significantly correlate with clinical stage, while MRP1 overexpression was significantly associated with poor survival.

No MeSH data available.


Related in: MedlinePlus