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Magnetic Resonance Imaging of Cartilage Repair: A Review.

Trattnig S, Winalski CS, Marlovits S, Jurvelin JS, Welsch GH, Potter HG - Cartilage (2011)

Bottom Line: Articular cartilage lesions are a common pathology of the knee joint, and many patients may benefit from cartilage repair surgeries that offer the chance to avoid the development of osteoarthritis or delay its progression.This goal is best fulfilled by magnetic resonance imaging (MRI).In the third section, a short overview is provided on the regulatory issues of the United States Food and Drug Administration (FDA) and the European Medicines Agency (EMEA) regarding MR follow-up studies of patients after cartilage repair surgeries.

View Article: PubMed Central - PubMed

Affiliation: MR Centre - High Field MR, Department of Radiology, Medical University of Vienna, Vienna, Austria.

ABSTRACT
Articular cartilage lesions are a common pathology of the knee joint, and many patients may benefit from cartilage repair surgeries that offer the chance to avoid the development of osteoarthritis or delay its progression. Cartilage repair surgery, no matter the technique, requires a noninvasive, standardized, and high-quality longitudinal method to assess the structure of the repair tissue. This goal is best fulfilled by magnetic resonance imaging (MRI). The present article provides an overview of the current state of the art of MRI of cartilage repair. In the first 2 sections, preclinical and clinical MRI of cartilage repair tissue are described with a focus on morphological depiction of cartilage and the use of functional (biochemical) MR methodologies for the visualization of the ultrastructure of cartilage repair. In the third section, a short overview is provided on the regulatory issues of the United States Food and Drug Administration (FDA) and the European Medicines Agency (EMEA) regarding MR follow-up studies of patients after cartilage repair surgeries.

No MeSH data available.


Related in: MedlinePlus

Axial 3-D magnetization transfer (MT)–weighted images of a 17-year-old male patient 3 months after matrix-associated autologous chondrocyte transplantation (MACT) of the patella. MT-saturated (a) and MT-free (b) images and the corresponding MT contrast (MTC) map (c). The MTC map shows clearly lower MTC ratio within the repair tissue (arrows).
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fig7-1947603509360209: Axial 3-D magnetization transfer (MT)–weighted images of a 17-year-old male patient 3 months after matrix-associated autologous chondrocyte transplantation (MACT) of the patella. MT-saturated (a) and MT-free (b) images and the corresponding MT contrast (MTC) map (c). The MTC map shows clearly lower MTC ratio within the repair tissue (arrows).

Mentions: The use of magnetization transfer (MT) imaging for articular cartilage was first described by Wolff et al.134 MT effects are based on the interaction of 2 different proton pools, the free (unbound) water pool, which is visible by MRI, and the unseen, very short T2 water pool that is bound to macromolecules. After saturation of the magnetization of bound water molecules by off-resonance or binomial pulses, the equilibrium is shifted to the bound proton pool, which results in a reduction of the observable magnetization and, thus, in a reduction of the MR signal. Thus, MT is specific for tissues with a large number of macromolecules and may provide a quantitative method for tissue characterization of basic macromolecular dynamics and chemistry.134-139 In the evaluation of articular cartilage, in vitro studies140,141 show that collagen concentration and collagen orientation may possibly play the most important role for magnetization transfer contrast (MTC). MT has been used for the quantitative in vivo evaluation of articular cartilage, with promising results for cartilage repair (Fig. 7).142,143


Magnetic Resonance Imaging of Cartilage Repair: A Review.

Trattnig S, Winalski CS, Marlovits S, Jurvelin JS, Welsch GH, Potter HG - Cartilage (2011)

Axial 3-D magnetization transfer (MT)–weighted images of a 17-year-old male patient 3 months after matrix-associated autologous chondrocyte transplantation (MACT) of the patella. MT-saturated (a) and MT-free (b) images and the corresponding MT contrast (MTC) map (c). The MTC map shows clearly lower MTC ratio within the repair tissue (arrows).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4300792&req=5

fig7-1947603509360209: Axial 3-D magnetization transfer (MT)–weighted images of a 17-year-old male patient 3 months after matrix-associated autologous chondrocyte transplantation (MACT) of the patella. MT-saturated (a) and MT-free (b) images and the corresponding MT contrast (MTC) map (c). The MTC map shows clearly lower MTC ratio within the repair tissue (arrows).
Mentions: The use of magnetization transfer (MT) imaging for articular cartilage was first described by Wolff et al.134 MT effects are based on the interaction of 2 different proton pools, the free (unbound) water pool, which is visible by MRI, and the unseen, very short T2 water pool that is bound to macromolecules. After saturation of the magnetization of bound water molecules by off-resonance or binomial pulses, the equilibrium is shifted to the bound proton pool, which results in a reduction of the observable magnetization and, thus, in a reduction of the MR signal. Thus, MT is specific for tissues with a large number of macromolecules and may provide a quantitative method for tissue characterization of basic macromolecular dynamics and chemistry.134-139 In the evaluation of articular cartilage, in vitro studies140,141 show that collagen concentration and collagen orientation may possibly play the most important role for magnetization transfer contrast (MTC). MT has been used for the quantitative in vivo evaluation of articular cartilage, with promising results for cartilage repair (Fig. 7).142,143

Bottom Line: Articular cartilage lesions are a common pathology of the knee joint, and many patients may benefit from cartilage repair surgeries that offer the chance to avoid the development of osteoarthritis or delay its progression.This goal is best fulfilled by magnetic resonance imaging (MRI).In the third section, a short overview is provided on the regulatory issues of the United States Food and Drug Administration (FDA) and the European Medicines Agency (EMEA) regarding MR follow-up studies of patients after cartilage repair surgeries.

View Article: PubMed Central - PubMed

Affiliation: MR Centre - High Field MR, Department of Radiology, Medical University of Vienna, Vienna, Austria.

ABSTRACT
Articular cartilage lesions are a common pathology of the knee joint, and many patients may benefit from cartilage repair surgeries that offer the chance to avoid the development of osteoarthritis or delay its progression. Cartilage repair surgery, no matter the technique, requires a noninvasive, standardized, and high-quality longitudinal method to assess the structure of the repair tissue. This goal is best fulfilled by magnetic resonance imaging (MRI). The present article provides an overview of the current state of the art of MRI of cartilage repair. In the first 2 sections, preclinical and clinical MRI of cartilage repair tissue are described with a focus on morphological depiction of cartilage and the use of functional (biochemical) MR methodologies for the visualization of the ultrastructure of cartilage repair. In the third section, a short overview is provided on the regulatory issues of the United States Food and Drug Administration (FDA) and the European Medicines Agency (EMEA) regarding MR follow-up studies of patients after cartilage repair surgeries.

No MeSH data available.


Related in: MedlinePlus