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Magnetic Resonance Imaging of Cartilage Repair: A Review.

Trattnig S, Winalski CS, Marlovits S, Jurvelin JS, Welsch GH, Potter HG - Cartilage (2011)

Bottom Line: Articular cartilage lesions are a common pathology of the knee joint, and many patients may benefit from cartilage repair surgeries that offer the chance to avoid the development of osteoarthritis or delay its progression.This goal is best fulfilled by magnetic resonance imaging (MRI).In the third section, a short overview is provided on the regulatory issues of the United States Food and Drug Administration (FDA) and the European Medicines Agency (EMEA) regarding MR follow-up studies of patients after cartilage repair surgeries.

View Article: PubMed Central - PubMed

Affiliation: MR Centre - High Field MR, Department of Radiology, Medical University of Vienna, Vienna, Austria.

ABSTRACT
Articular cartilage lesions are a common pathology of the knee joint, and many patients may benefit from cartilage repair surgeries that offer the chance to avoid the development of osteoarthritis or delay its progression. Cartilage repair surgery, no matter the technique, requires a noninvasive, standardized, and high-quality longitudinal method to assess the structure of the repair tissue. This goal is best fulfilled by magnetic resonance imaging (MRI). The present article provides an overview of the current state of the art of MRI of cartilage repair. In the first 2 sections, preclinical and clinical MRI of cartilage repair tissue are described with a focus on morphological depiction of cartilage and the use of functional (biochemical) MR methodologies for the visualization of the ultrastructure of cartilage repair. In the third section, a short overview is provided on the regulatory issues of the United States Food and Drug Administration (FDA) and the European Medicines Agency (EMEA) regarding MR follow-up studies of patients after cartilage repair surgeries.

No MeSH data available.


Related in: MedlinePlus

High-resolution, isotropic, 0.5 × 0.5 × 0.5-mm fat-suppressed 3-D proton density (PD) SPACE sequence (TR/TE: 1500/34) to assess postoperatively the cartilage repair tissue 6 months after microfracture (arrows, sagittal) (a), the position and orientation after anterior cruciate ligament surgery (coronal) (b), and the menisci (axial) (c) in a 30-year-old male patient using multiplanar angulated reconstruction from one isotropic data set.
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fig2-1947603509360209: High-resolution, isotropic, 0.5 × 0.5 × 0.5-mm fat-suppressed 3-D proton density (PD) SPACE sequence (TR/TE: 1500/34) to assess postoperatively the cartilage repair tissue 6 months after microfracture (arrows, sagittal) (a), the position and orientation after anterior cruciate ligament surgery (coronal) (b), and the menisci (axial) (c) in a 30-year-old male patient using multiplanar angulated reconstruction from one isotropic data set.

Mentions: 3-D FSE sequences have also shown promising results in the assessment of cartilage lesions together with other internal knee derangements. In a comparison to 2-D FSE sequences, an isotropic (0.7 mm3) 3-D FSE-XETA could be reformatted in arbitrary planes with high-cartilage SNR.46 Another study found the related sequence, 3-D FSE-CUBE, to be more sensitive, but less specific, than standard 2-D acquisitions for the diagnosis of cartilage lesions.47 Although the use of isotropic 3-D sequences for cartilage volume and thickness measurements in the follow-up evaluation of cartilage repair procedures remains challenging, there is great potential of improved 3-D assessment of the cartilage repair tissue because of the lower sensitivity to postoperative magnetic susceptibility changes. Using image postprocessing viewing tools that provide MPRs, the interfaces of the cartilage repair tissue with native cartilage, subchondral bone, and joint fluid can be precisely evaluated in every plane, independent of its location within the joint (Fig. 2).


Magnetic Resonance Imaging of Cartilage Repair: A Review.

Trattnig S, Winalski CS, Marlovits S, Jurvelin JS, Welsch GH, Potter HG - Cartilage (2011)

High-resolution, isotropic, 0.5 × 0.5 × 0.5-mm fat-suppressed 3-D proton density (PD) SPACE sequence (TR/TE: 1500/34) to assess postoperatively the cartilage repair tissue 6 months after microfracture (arrows, sagittal) (a), the position and orientation after anterior cruciate ligament surgery (coronal) (b), and the menisci (axial) (c) in a 30-year-old male patient using multiplanar angulated reconstruction from one isotropic data set.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4300792&req=5

fig2-1947603509360209: High-resolution, isotropic, 0.5 × 0.5 × 0.5-mm fat-suppressed 3-D proton density (PD) SPACE sequence (TR/TE: 1500/34) to assess postoperatively the cartilage repair tissue 6 months after microfracture (arrows, sagittal) (a), the position and orientation after anterior cruciate ligament surgery (coronal) (b), and the menisci (axial) (c) in a 30-year-old male patient using multiplanar angulated reconstruction from one isotropic data set.
Mentions: 3-D FSE sequences have also shown promising results in the assessment of cartilage lesions together with other internal knee derangements. In a comparison to 2-D FSE sequences, an isotropic (0.7 mm3) 3-D FSE-XETA could be reformatted in arbitrary planes with high-cartilage SNR.46 Another study found the related sequence, 3-D FSE-CUBE, to be more sensitive, but less specific, than standard 2-D acquisitions for the diagnosis of cartilage lesions.47 Although the use of isotropic 3-D sequences for cartilage volume and thickness measurements in the follow-up evaluation of cartilage repair procedures remains challenging, there is great potential of improved 3-D assessment of the cartilage repair tissue because of the lower sensitivity to postoperative magnetic susceptibility changes. Using image postprocessing viewing tools that provide MPRs, the interfaces of the cartilage repair tissue with native cartilage, subchondral bone, and joint fluid can be precisely evaluated in every plane, independent of its location within the joint (Fig. 2).

Bottom Line: Articular cartilage lesions are a common pathology of the knee joint, and many patients may benefit from cartilage repair surgeries that offer the chance to avoid the development of osteoarthritis or delay its progression.This goal is best fulfilled by magnetic resonance imaging (MRI).In the third section, a short overview is provided on the regulatory issues of the United States Food and Drug Administration (FDA) and the European Medicines Agency (EMEA) regarding MR follow-up studies of patients after cartilage repair surgeries.

View Article: PubMed Central - PubMed

Affiliation: MR Centre - High Field MR, Department of Radiology, Medical University of Vienna, Vienna, Austria.

ABSTRACT
Articular cartilage lesions are a common pathology of the knee joint, and many patients may benefit from cartilage repair surgeries that offer the chance to avoid the development of osteoarthritis or delay its progression. Cartilage repair surgery, no matter the technique, requires a noninvasive, standardized, and high-quality longitudinal method to assess the structure of the repair tissue. This goal is best fulfilled by magnetic resonance imaging (MRI). The present article provides an overview of the current state of the art of MRI of cartilage repair. In the first 2 sections, preclinical and clinical MRI of cartilage repair tissue are described with a focus on morphological depiction of cartilage and the use of functional (biochemical) MR methodologies for the visualization of the ultrastructure of cartilage repair. In the third section, a short overview is provided on the regulatory issues of the United States Food and Drug Administration (FDA) and the European Medicines Agency (EMEA) regarding MR follow-up studies of patients after cartilage repair surgeries.

No MeSH data available.


Related in: MedlinePlus