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Magnetic Resonance Imaging of Cartilage Repair: A Review.

Trattnig S, Winalski CS, Marlovits S, Jurvelin JS, Welsch GH, Potter HG - Cartilage (2011)

Bottom Line: Articular cartilage lesions are a common pathology of the knee joint, and many patients may benefit from cartilage repair surgeries that offer the chance to avoid the development of osteoarthritis or delay its progression.This goal is best fulfilled by magnetic resonance imaging (MRI).In the third section, a short overview is provided on the regulatory issues of the United States Food and Drug Administration (FDA) and the European Medicines Agency (EMEA) regarding MR follow-up studies of patients after cartilage repair surgeries.

View Article: PubMed Central - PubMed

Affiliation: MR Centre - High Field MR, Department of Radiology, Medical University of Vienna, Vienna, Austria.

ABSTRACT
Articular cartilage lesions are a common pathology of the knee joint, and many patients may benefit from cartilage repair surgeries that offer the chance to avoid the development of osteoarthritis or delay its progression. Cartilage repair surgery, no matter the technique, requires a noninvasive, standardized, and high-quality longitudinal method to assess the structure of the repair tissue. This goal is best fulfilled by magnetic resonance imaging (MRI). The present article provides an overview of the current state of the art of MRI of cartilage repair. In the first 2 sections, preclinical and clinical MRI of cartilage repair tissue are described with a focus on morphological depiction of cartilage and the use of functional (biochemical) MR methodologies for the visualization of the ultrastructure of cartilage repair. In the third section, a short overview is provided on the regulatory issues of the United States Food and Drug Administration (FDA) and the European Medicines Agency (EMEA) regarding MR follow-up studies of patients after cartilage repair surgeries.

No MeSH data available.


Related in: MedlinePlus

Conventional axial proton density fast spin-echo (PD FSE) sequence (TR/TE: 2400/28) with ultra-high resolution (512 × 512; 12 cm; slice thickness: 2 mm) of a 17-year-old male patient 3 months after matrix-associated autologous chondrocyte transplantation (MACT) of the patella. The double-layered scaffold is still visible.
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fig1-1947603509360209: Conventional axial proton density fast spin-echo (PD FSE) sequence (TR/TE: 2400/28) with ultra-high resolution (512 × 512; 12 cm; slice thickness: 2 mm) of a 17-year-old male patient 3 months after matrix-associated autologous chondrocyte transplantation (MACT) of the patella. The double-layered scaffold is still visible.

Mentions: Standard morphological MR evaluation of cartilage repair tissue can be performed using the same acquisition techniques as those used for native cartilage.32 The most widely used MRI techniques are intermediate-weighted fast spin-echo (FSE) and 3-D fat-suppressed T1-weighted gradient-echo (GRE) acquisition.29,30,32-34 Whereas the GRE sequence visualizes cartilage defects attributable to T1 differences between cartilage and fluid, the FSE sequence uses differences in T2 weighting. Compared with fluid, cartilage is higher in signal intensity on fat-suppressed T1 weighting and lower on intermediate or T2 weighting. While the T1-weighted, 3-D GRE sequence with fat suppression is suitable for visualization of the thickness and surface of cartilage and allows 3-D volume measurements, the FSE sequence is more sensitive for assessment of the internal cartilage structure.29,32,33 In postoperative imaging, one advantage of FSE sequences is its low sensitivity to artifacts, which are suppressed by the 180° refocusing pulses of the FSE (Fig. 1). Both sequences, the fat-suppressed, 3-D GRE and the FSE, are showing excellent results with high sensitivity, specificity, and accuracy for detecting cartilage lesions in the knee.29,32,35


Magnetic Resonance Imaging of Cartilage Repair: A Review.

Trattnig S, Winalski CS, Marlovits S, Jurvelin JS, Welsch GH, Potter HG - Cartilage (2011)

Conventional axial proton density fast spin-echo (PD FSE) sequence (TR/TE: 2400/28) with ultra-high resolution (512 × 512; 12 cm; slice thickness: 2 mm) of a 17-year-old male patient 3 months after matrix-associated autologous chondrocyte transplantation (MACT) of the patella. The double-layered scaffold is still visible.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4300792&req=5

fig1-1947603509360209: Conventional axial proton density fast spin-echo (PD FSE) sequence (TR/TE: 2400/28) with ultra-high resolution (512 × 512; 12 cm; slice thickness: 2 mm) of a 17-year-old male patient 3 months after matrix-associated autologous chondrocyte transplantation (MACT) of the patella. The double-layered scaffold is still visible.
Mentions: Standard morphological MR evaluation of cartilage repair tissue can be performed using the same acquisition techniques as those used for native cartilage.32 The most widely used MRI techniques are intermediate-weighted fast spin-echo (FSE) and 3-D fat-suppressed T1-weighted gradient-echo (GRE) acquisition.29,30,32-34 Whereas the GRE sequence visualizes cartilage defects attributable to T1 differences between cartilage and fluid, the FSE sequence uses differences in T2 weighting. Compared with fluid, cartilage is higher in signal intensity on fat-suppressed T1 weighting and lower on intermediate or T2 weighting. While the T1-weighted, 3-D GRE sequence with fat suppression is suitable for visualization of the thickness and surface of cartilage and allows 3-D volume measurements, the FSE sequence is more sensitive for assessment of the internal cartilage structure.29,32,33 In postoperative imaging, one advantage of FSE sequences is its low sensitivity to artifacts, which are suppressed by the 180° refocusing pulses of the FSE (Fig. 1). Both sequences, the fat-suppressed, 3-D GRE and the FSE, are showing excellent results with high sensitivity, specificity, and accuracy for detecting cartilage lesions in the knee.29,32,35

Bottom Line: Articular cartilage lesions are a common pathology of the knee joint, and many patients may benefit from cartilage repair surgeries that offer the chance to avoid the development of osteoarthritis or delay its progression.This goal is best fulfilled by magnetic resonance imaging (MRI).In the third section, a short overview is provided on the regulatory issues of the United States Food and Drug Administration (FDA) and the European Medicines Agency (EMEA) regarding MR follow-up studies of patients after cartilage repair surgeries.

View Article: PubMed Central - PubMed

Affiliation: MR Centre - High Field MR, Department of Radiology, Medical University of Vienna, Vienna, Austria.

ABSTRACT
Articular cartilage lesions are a common pathology of the knee joint, and many patients may benefit from cartilage repair surgeries that offer the chance to avoid the development of osteoarthritis or delay its progression. Cartilage repair surgery, no matter the technique, requires a noninvasive, standardized, and high-quality longitudinal method to assess the structure of the repair tissue. This goal is best fulfilled by magnetic resonance imaging (MRI). The present article provides an overview of the current state of the art of MRI of cartilage repair. In the first 2 sections, preclinical and clinical MRI of cartilage repair tissue are described with a focus on morphological depiction of cartilage and the use of functional (biochemical) MR methodologies for the visualization of the ultrastructure of cartilage repair. In the third section, a short overview is provided on the regulatory issues of the United States Food and Drug Administration (FDA) and the European Medicines Agency (EMEA) regarding MR follow-up studies of patients after cartilage repair surgeries.

No MeSH data available.


Related in: MedlinePlus