Limits...
Diagnosis of Osteoarthritis by Cartilage Surface Smoothness Quantified Automatically from Knee MRI.

Tummala S, Bay-Jensen AC, Karsdal MA, Dam EB - Cartilage (2011)

Bottom Line: A total of 140 subjects concluded the 21-month study.The diagnostic smoothness markers performed at least similar to JSW and were superior to volume markers (e.g., the AUC for femoral smoothness of 0.80 was higher than the 0.57 for volume, P < 0.0001, and marginally higher than 0.73 for JSW, P = 0.25).Thereby, smoothness markers may allow detection and monitoring of OA-supplemented currently accepted markers.

View Article: PubMed Central - PubMed

Affiliation: eScience Center, Department of Computer Science, University of Copenhagen, Copenhagen, Denmark.

ABSTRACT

Objective: We investigated whether surface smoothness of articular cartilage in the medial tibiofemoral compartment quantified from magnetic resonance imaging (MRI) could be appropriate as a diagnostic marker of osteoarthritis (OA).

Method: At baseline, 159 community-based subjects aged 21 to 81 with normal or OA-affected knees were recruited to provide a broad range of OA states. Smoothness was quantified using an automatic framework from low-field MRI in the tibial, femoral, and femoral subcompartments. Diagnostic ability of smoothness was evaluated by comparison with conventional OA markers, specifically cartilage volume from MRI, joint space width (JSW) from radiographs, and pain scores.

Results: A total of 140 subjects concluded the 21-month study. Cartilage smoothness provided diagnostic ability in all compartments (P < 0.0001). The diagnostic smoothness markers performed at least similar to JSW and were superior to volume markers (e.g., the AUC for femoral smoothness of 0.80 was higher than the 0.57 for volume, P < 0.0001, and marginally higher than 0.73 for JSW, P = 0.25). The smoothness markers allowed diagnostic detection of pain presence (P < 0.05) and showed some correlation with pain severity (e.g., r = -0.32). The longitudinal change in smoothness was correlated with cartilage loss (r up to 0.60, P < 0.0001 in all compartments).

Conclusions: This study demonstrated the potential of cartilage smoothness markers for diagnosis of moderate radiographic OA. Furthermore, correlations between smoothness and pain values and smoothness loss and cartilage loss supported a link to progression of OA. Thereby, smoothness markers may allow detection and monitoring of OA-supplemented currently accepted markers.

No MeSH data available.


Related in: MedlinePlus

The smoothness markers at each level of osteoarthritis for the (A) tibial and (B) femoral compartments. The mean smoothness score is given, with the standard error of the mean given as error bars. The Kellgren and Lawrence (KL) ≤1 and KL >1 subpopulations are compared to the left of the dashed lines. To the right, the scores are given for each level of KL. *P < 0.05. **P < 0.01. ****P < 0.0001.
© Copyright Policy
Related In: Results  -  Collection


getmorefigures.php?uid=PMC4300790&req=5

fig3-1947603510381097: The smoothness markers at each level of osteoarthritis for the (A) tibial and (B) femoral compartments. The mean smoothness score is given, with the standard error of the mean given as error bars. The Kellgren and Lawrence (KL) ≤1 and KL >1 subpopulations are compared to the left of the dashed lines. To the right, the scores are given for each level of KL. *P < 0.05. **P < 0.01. ****P < 0.0001.

Mentions: The potentiality of the smoothness marker in diagnosing different degrees of radiographic OA, indicated by KL score, is illustrated for the tibial (Fig. 3A) and femoral (Fig. 3B) compartments. The smoothness marker allowed cross-sectional separation of KL levels above 1.


Diagnosis of Osteoarthritis by Cartilage Surface Smoothness Quantified Automatically from Knee MRI.

Tummala S, Bay-Jensen AC, Karsdal MA, Dam EB - Cartilage (2011)

The smoothness markers at each level of osteoarthritis for the (A) tibial and (B) femoral compartments. The mean smoothness score is given, with the standard error of the mean given as error bars. The Kellgren and Lawrence (KL) ≤1 and KL >1 subpopulations are compared to the left of the dashed lines. To the right, the scores are given for each level of KL. *P < 0.05. **P < 0.01. ****P < 0.0001.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4300790&req=5

fig3-1947603510381097: The smoothness markers at each level of osteoarthritis for the (A) tibial and (B) femoral compartments. The mean smoothness score is given, with the standard error of the mean given as error bars. The Kellgren and Lawrence (KL) ≤1 and KL >1 subpopulations are compared to the left of the dashed lines. To the right, the scores are given for each level of KL. *P < 0.05. **P < 0.01. ****P < 0.0001.
Mentions: The potentiality of the smoothness marker in diagnosing different degrees of radiographic OA, indicated by KL score, is illustrated for the tibial (Fig. 3A) and femoral (Fig. 3B) compartments. The smoothness marker allowed cross-sectional separation of KL levels above 1.

Bottom Line: A total of 140 subjects concluded the 21-month study.The diagnostic smoothness markers performed at least similar to JSW and were superior to volume markers (e.g., the AUC for femoral smoothness of 0.80 was higher than the 0.57 for volume, P < 0.0001, and marginally higher than 0.73 for JSW, P = 0.25).Thereby, smoothness markers may allow detection and monitoring of OA-supplemented currently accepted markers.

View Article: PubMed Central - PubMed

Affiliation: eScience Center, Department of Computer Science, University of Copenhagen, Copenhagen, Denmark.

ABSTRACT

Objective: We investigated whether surface smoothness of articular cartilage in the medial tibiofemoral compartment quantified from magnetic resonance imaging (MRI) could be appropriate as a diagnostic marker of osteoarthritis (OA).

Method: At baseline, 159 community-based subjects aged 21 to 81 with normal or OA-affected knees were recruited to provide a broad range of OA states. Smoothness was quantified using an automatic framework from low-field MRI in the tibial, femoral, and femoral subcompartments. Diagnostic ability of smoothness was evaluated by comparison with conventional OA markers, specifically cartilage volume from MRI, joint space width (JSW) from radiographs, and pain scores.

Results: A total of 140 subjects concluded the 21-month study. Cartilage smoothness provided diagnostic ability in all compartments (P < 0.0001). The diagnostic smoothness markers performed at least similar to JSW and were superior to volume markers (e.g., the AUC for femoral smoothness of 0.80 was higher than the 0.57 for volume, P < 0.0001, and marginally higher than 0.73 for JSW, P = 0.25). The smoothness markers allowed diagnostic detection of pain presence (P < 0.05) and showed some correlation with pain severity (e.g., r = -0.32). The longitudinal change in smoothness was correlated with cartilage loss (r up to 0.60, P < 0.0001 in all compartments).

Conclusions: This study demonstrated the potential of cartilage smoothness markers for diagnosis of moderate radiographic OA. Furthermore, correlations between smoothness and pain values and smoothness loss and cartilage loss supported a link to progression of OA. Thereby, smoothness markers may allow detection and monitoring of OA-supplemented currently accepted markers.

No MeSH data available.


Related in: MedlinePlus