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Role of c-Maf in Chondrocyte Differentiation: A Review.

Hong E, Di Cesare PE, Haudenschild DR - Cartilage (2011)

Bottom Line: Chondrocyte differentiation in the growth plate is an important process for the longitudinal growth of endochondral bones.Mafs are a subfamily of the basic ZIP (bZIP) transcription factor superfamily, which act as key regulators of tissue-specific gene expression and terminal differentiation in many tissues.There is increasing evidence that c-Maf and its splicing variant Lc-Maf play a role in chondrocyte differentiation in a temporal-spatial manner.

View Article: PubMed Central - PubMed

Affiliation: University of California Davis Medical Center, Division of Orthopaedic Research, Department of Orthopaedic Surgery, Sacramento, CA, USA.

ABSTRACT
Chondrocyte differentiation in the growth plate is an important process for the longitudinal growth of endochondral bones. Sox9 and Runx2 are the most often-studied transcriptional regulators of the chondrocyte differentiation process, but the importance of additional factors is also becoming apparent. Mafs are a subfamily of the basic ZIP (bZIP) transcription factor superfamily, which act as key regulators of tissue-specific gene expression and terminal differentiation in many tissues. There is increasing evidence that c-Maf and its splicing variant Lc-Maf play a role in chondrocyte differentiation in a temporal-spatial manner. This review summarizes the functions of c-Maf in chondrocyte differentiation and discusses the possible role of c-Maf in osteoarthritis progression.

No MeSH data available.


Related in: MedlinePlus

Schematics of c-Maf target genes in chondrocytes and possible pathways regulating c-Maf regulation. FGF/MAPK/ERK pathway may activate and affect the stability of c-Maf, based on homology with interactions affecting MafA. Some interactions are proposed based on homology of the phosphorylation/ubiquitination sites between MafA and c-Maf. These interactions still need to be verified for c-Maf, as clarified in the text.
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fig3-1947603510377464: Schematics of c-Maf target genes in chondrocytes and possible pathways regulating c-Maf regulation. FGF/MAPK/ERK pathway may activate and affect the stability of c-Maf, based on homology with interactions affecting MafA. Some interactions are proposed based on homology of the phosphorylation/ubiquitination sites between MafA and c-Maf. These interactions still need to be verified for c-Maf, as clarified in the text.

Mentions: Although Maf was first identified as a retroviral oncoprotein, the physiological functions of Maf family proteins include regulatory roles in a wide variety of cell- and tissue-specific gene expression and in cell differentiation during development.41 The target genes of Maf transcription factors in tissues are well summarized (see review by Kataoka41). This section focuses on c-Maf targets in chondrocytes, summarizing various lines of evidence that c-Maf regulates genes related to chondrocyte differentiation and the progression of osteoarthritis. This growing list of genes includes matrix metalloproteinase-13 (MMP-13), connective tissue growth factor (CTGF), Col2a1, and Col27a1 (Fig. 3).


Role of c-Maf in Chondrocyte Differentiation: A Review.

Hong E, Di Cesare PE, Haudenschild DR - Cartilage (2011)

Schematics of c-Maf target genes in chondrocytes and possible pathways regulating c-Maf regulation. FGF/MAPK/ERK pathway may activate and affect the stability of c-Maf, based on homology with interactions affecting MafA. Some interactions are proposed based on homology of the phosphorylation/ubiquitination sites between MafA and c-Maf. These interactions still need to be verified for c-Maf, as clarified in the text.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4300789&req=5

fig3-1947603510377464: Schematics of c-Maf target genes in chondrocytes and possible pathways regulating c-Maf regulation. FGF/MAPK/ERK pathway may activate and affect the stability of c-Maf, based on homology with interactions affecting MafA. Some interactions are proposed based on homology of the phosphorylation/ubiquitination sites between MafA and c-Maf. These interactions still need to be verified for c-Maf, as clarified in the text.
Mentions: Although Maf was first identified as a retroviral oncoprotein, the physiological functions of Maf family proteins include regulatory roles in a wide variety of cell- and tissue-specific gene expression and in cell differentiation during development.41 The target genes of Maf transcription factors in tissues are well summarized (see review by Kataoka41). This section focuses on c-Maf targets in chondrocytes, summarizing various lines of evidence that c-Maf regulates genes related to chondrocyte differentiation and the progression of osteoarthritis. This growing list of genes includes matrix metalloproteinase-13 (MMP-13), connective tissue growth factor (CTGF), Col2a1, and Col27a1 (Fig. 3).

Bottom Line: Chondrocyte differentiation in the growth plate is an important process for the longitudinal growth of endochondral bones.Mafs are a subfamily of the basic ZIP (bZIP) transcription factor superfamily, which act as key regulators of tissue-specific gene expression and terminal differentiation in many tissues.There is increasing evidence that c-Maf and its splicing variant Lc-Maf play a role in chondrocyte differentiation in a temporal-spatial manner.

View Article: PubMed Central - PubMed

Affiliation: University of California Davis Medical Center, Division of Orthopaedic Research, Department of Orthopaedic Surgery, Sacramento, CA, USA.

ABSTRACT
Chondrocyte differentiation in the growth plate is an important process for the longitudinal growth of endochondral bones. Sox9 and Runx2 are the most often-studied transcriptional regulators of the chondrocyte differentiation process, but the importance of additional factors is also becoming apparent. Mafs are a subfamily of the basic ZIP (bZIP) transcription factor superfamily, which act as key regulators of tissue-specific gene expression and terminal differentiation in many tissues. There is increasing evidence that c-Maf and its splicing variant Lc-Maf play a role in chondrocyte differentiation in a temporal-spatial manner. This review summarizes the functions of c-Maf in chondrocyte differentiation and discusses the possible role of c-Maf in osteoarthritis progression.

No MeSH data available.


Related in: MedlinePlus