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Role of c-Maf in Chondrocyte Differentiation: A Review.

Hong E, Di Cesare PE, Haudenschild DR - Cartilage (2011)

Bottom Line: Chondrocyte differentiation in the growth plate is an important process for the longitudinal growth of endochondral bones.Mafs are a subfamily of the basic ZIP (bZIP) transcription factor superfamily, which act as key regulators of tissue-specific gene expression and terminal differentiation in many tissues.There is increasing evidence that c-Maf and its splicing variant Lc-Maf play a role in chondrocyte differentiation in a temporal-spatial manner.

View Article: PubMed Central - PubMed

Affiliation: University of California Davis Medical Center, Division of Orthopaedic Research, Department of Orthopaedic Surgery, Sacramento, CA, USA.

ABSTRACT
Chondrocyte differentiation in the growth plate is an important process for the longitudinal growth of endochondral bones. Sox9 and Runx2 are the most often-studied transcriptional regulators of the chondrocyte differentiation process, but the importance of additional factors is also becoming apparent. Mafs are a subfamily of the basic ZIP (bZIP) transcription factor superfamily, which act as key regulators of tissue-specific gene expression and terminal differentiation in many tissues. There is increasing evidence that c-Maf and its splicing variant Lc-Maf play a role in chondrocyte differentiation in a temporal-spatial manner. This review summarizes the functions of c-Maf in chondrocyte differentiation and discusses the possible role of c-Maf in osteoarthritis progression.

No MeSH data available.


Related in: MedlinePlus

Schematic representation of c-Maf genomic structure and predicted functional domains. c-Maf and its RNA splice variant Lc-Maf (long form c-Maf) contain the same 5′ untranslated region. c-Maf is transcribed from a single exon, and through mRNA splicing, Lc-Maf has a frame shift that alters the last amino acid of c-Maf Exon 1 and codes for an additional 10 amino acids (in mouse) or 30 amino acids (in human). The mechanism of splicing is unknown. Intron/exon sizes are not drawn to scale.
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fig1-1947603510377464: Schematic representation of c-Maf genomic structure and predicted functional domains. c-Maf and its RNA splice variant Lc-Maf (long form c-Maf) contain the same 5′ untranslated region. c-Maf is transcribed from a single exon, and through mRNA splicing, Lc-Maf has a frame shift that alters the last amino acid of c-Maf Exon 1 and codes for an additional 10 amino acids (in mouse) or 30 amino acids (in human). The mechanism of splicing is unknown. Intron/exon sizes are not drawn to scale.

Mentions: The founding member of Maf family, v-Maf (musculoaponeurotic fibrosarcoma), was originally identified as a retroviral oncoprotein, and then cellular counterparts, c-Mafs, were cloned from a number of vertebrate genomes.16 The Maf family is currently subdivided into two groups, small Maf (MafF, MafG, MafK, MafT, and MafS) and large Maf (c-Maf, MafA, MafB, and Nrl [neural retina leucine zipper]) proteins based on their domain structure and function (Table 1). A transcript variant of c-Maf, Lc-Maf, also has been reported15 (Fig. 1). The large Maf proteins contain a conserved N-terminal transactivation domain, whereas the small Maf proteins lack this transactivation domain.17 Based on the strong sequence conservation, the members of the Maf family are classified under the bZIP transcription factor superfamily.


Role of c-Maf in Chondrocyte Differentiation: A Review.

Hong E, Di Cesare PE, Haudenschild DR - Cartilage (2011)

Schematic representation of c-Maf genomic structure and predicted functional domains. c-Maf and its RNA splice variant Lc-Maf (long form c-Maf) contain the same 5′ untranslated region. c-Maf is transcribed from a single exon, and through mRNA splicing, Lc-Maf has a frame shift that alters the last amino acid of c-Maf Exon 1 and codes for an additional 10 amino acids (in mouse) or 30 amino acids (in human). The mechanism of splicing is unknown. Intron/exon sizes are not drawn to scale.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4300789&req=5

fig1-1947603510377464: Schematic representation of c-Maf genomic structure and predicted functional domains. c-Maf and its RNA splice variant Lc-Maf (long form c-Maf) contain the same 5′ untranslated region. c-Maf is transcribed from a single exon, and through mRNA splicing, Lc-Maf has a frame shift that alters the last amino acid of c-Maf Exon 1 and codes for an additional 10 amino acids (in mouse) or 30 amino acids (in human). The mechanism of splicing is unknown. Intron/exon sizes are not drawn to scale.
Mentions: The founding member of Maf family, v-Maf (musculoaponeurotic fibrosarcoma), was originally identified as a retroviral oncoprotein, and then cellular counterparts, c-Mafs, were cloned from a number of vertebrate genomes.16 The Maf family is currently subdivided into two groups, small Maf (MafF, MafG, MafK, MafT, and MafS) and large Maf (c-Maf, MafA, MafB, and Nrl [neural retina leucine zipper]) proteins based on their domain structure and function (Table 1). A transcript variant of c-Maf, Lc-Maf, also has been reported15 (Fig. 1). The large Maf proteins contain a conserved N-terminal transactivation domain, whereas the small Maf proteins lack this transactivation domain.17 Based on the strong sequence conservation, the members of the Maf family are classified under the bZIP transcription factor superfamily.

Bottom Line: Chondrocyte differentiation in the growth plate is an important process for the longitudinal growth of endochondral bones.Mafs are a subfamily of the basic ZIP (bZIP) transcription factor superfamily, which act as key regulators of tissue-specific gene expression and terminal differentiation in many tissues.There is increasing evidence that c-Maf and its splicing variant Lc-Maf play a role in chondrocyte differentiation in a temporal-spatial manner.

View Article: PubMed Central - PubMed

Affiliation: University of California Davis Medical Center, Division of Orthopaedic Research, Department of Orthopaedic Surgery, Sacramento, CA, USA.

ABSTRACT
Chondrocyte differentiation in the growth plate is an important process for the longitudinal growth of endochondral bones. Sox9 and Runx2 are the most often-studied transcriptional regulators of the chondrocyte differentiation process, but the importance of additional factors is also becoming apparent. Mafs are a subfamily of the basic ZIP (bZIP) transcription factor superfamily, which act as key regulators of tissue-specific gene expression and terminal differentiation in many tissues. There is increasing evidence that c-Maf and its splicing variant Lc-Maf play a role in chondrocyte differentiation in a temporal-spatial manner. This review summarizes the functions of c-Maf in chondrocyte differentiation and discusses the possible role of c-Maf in osteoarthritis progression.

No MeSH data available.


Related in: MedlinePlus