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Diagnostic accuracy of single baseline measurement of Elecsys Troponin T high-sensitive assay for diagnosis of acute myocardial infarction in emergency department: systematic review and meta-analysis.

Zhelev Z, Hyde C, Youngman E, Rogers M, Fleming S, Slade T, Coelho H, Jones-Hughes T, Nikolaou V - BMJ (2015)

Bottom Line: The results for 14 ng/L and 3-5 ng/L cut-off values were pooled separately.However, this method should be part of a comprehensive triage strategy and may not be appropriate for patients who present less than three hours after symptom onset.PROSPERO registration number CRD42013003926.

View Article: PubMed Central - PubMed

Affiliation: Institute of Health Research, University of Exeter Medical School, Exeter EX2 4SG, UK Z.Zhelev@exeter.ac.uk.

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Fig 3 Summary receiver operating characteristics plot of sensitivity and specificity at 14 ng/L cut-off value. Each rectangle represents an individual study; size of symbol reflects inverse standard error of specificity (width) and sensitivity (height) estimates; solid spot in middle is summary sensitivity and specificity; inner ellipse represents 95% confidence region, and outer ellipse represents 95% prediction region
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fig3: Fig 3 Summary receiver operating characteristics plot of sensitivity and specificity at 14 ng/L cut-off value. Each rectangle represents an individual study; size of symbol reflects inverse standard error of specificity (width) and sensitivity (height) estimates; solid spot in middle is summary sensitivity and specificity; inner ellipse represents 95% confidence region, and outer ellipse represents 95% prediction region

Mentions: Pooling the results produced the following summary estimates: sensitivity 89.5% (95% confidence interval 86.3% to 92.1%), specificity 77.1% (68.7% to 83.7%), positive likelihood ratio 3.9 (2.8 to 5.4), and negative likelihood ratio 0.14 (0.10 to 0.18). The summary receiver operating characteristics plot (fig 3) shows the summary sensitivity and specificity (the solid blue spot in the middle) and the 95% confidence and prediction regions (the inner and outer ellipses, respectively).


Diagnostic accuracy of single baseline measurement of Elecsys Troponin T high-sensitive assay for diagnosis of acute myocardial infarction in emergency department: systematic review and meta-analysis.

Zhelev Z, Hyde C, Youngman E, Rogers M, Fleming S, Slade T, Coelho H, Jones-Hughes T, Nikolaou V - BMJ (2015)

Fig 3 Summary receiver operating characteristics plot of sensitivity and specificity at 14 ng/L cut-off value. Each rectangle represents an individual study; size of symbol reflects inverse standard error of specificity (width) and sensitivity (height) estimates; solid spot in middle is summary sensitivity and specificity; inner ellipse represents 95% confidence region, and outer ellipse represents 95% prediction region
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4300724&req=5

fig3: Fig 3 Summary receiver operating characteristics plot of sensitivity and specificity at 14 ng/L cut-off value. Each rectangle represents an individual study; size of symbol reflects inverse standard error of specificity (width) and sensitivity (height) estimates; solid spot in middle is summary sensitivity and specificity; inner ellipse represents 95% confidence region, and outer ellipse represents 95% prediction region
Mentions: Pooling the results produced the following summary estimates: sensitivity 89.5% (95% confidence interval 86.3% to 92.1%), specificity 77.1% (68.7% to 83.7%), positive likelihood ratio 3.9 (2.8 to 5.4), and negative likelihood ratio 0.14 (0.10 to 0.18). The summary receiver operating characteristics plot (fig 3) shows the summary sensitivity and specificity (the solid blue spot in the middle) and the 95% confidence and prediction regions (the inner and outer ellipses, respectively).

Bottom Line: The results for 14 ng/L and 3-5 ng/L cut-off values were pooled separately.However, this method should be part of a comprehensive triage strategy and may not be appropriate for patients who present less than three hours after symptom onset.PROSPERO registration number CRD42013003926.

View Article: PubMed Central - PubMed

Affiliation: Institute of Health Research, University of Exeter Medical School, Exeter EX2 4SG, UK Z.Zhelev@exeter.ac.uk.

Show MeSH
Related in: MedlinePlus