Limits...
The multiple sclerosis visual pathway cohort: understanding neurodegeneration in MS.

Martínez-Lapiscina EH, Fraga-Pumar E, Gabilondo I, Martínez-Heras E, Torres-Torres R, Ortiz-Pérez S, Llufriu S, Tercero A, Andorra M, Roca MF, Lampert E, Zubizarreta I, Saiz A, Sanchez-Dalmau B, Villoslada P - BMC Res Notes (2014)

Bottom Line: We started the recruitment of patients in the early phase of MS in 2010 and it remains permanently open.In addition, the imaging protocol includes both retinal (Optical Coherence Tomography and Wide-Field Fundus Imaging) and brain imaging (Magnetic Resonance Imaging).The analysis of the visual pathway with advance imaging and electrophysilogical tools in parallel with clinical information will provide significant and new knowledge regarding neurodegeneration in MS and provide new clinical and imaging biomarkers to help monitor disease progression in these patients.

View Article: PubMed Central - PubMed

Affiliation: Center of Neuroimmunology, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) - Hospital Clinic of Barcelona, Casanova 145, Planta 3A, 08036 Barcelona, Spain. pvilloslada@clinic.ub.es.

ABSTRACT

Background: Multiple Sclerosis (MS) is an immune-mediated disease of the Central Nervous System with two major underlying etiopathogenic processes: inflammation and neurodegeneration. The latter determines the prognosis of this disease. MS is the main cause of non-traumatic disability in middle-aged populations.

Findings: The MS-VisualPath Cohort was set up to study the neurodegenerative component of MS using advanced imaging techniques by focusing on analysis of the visual pathway in a middle-aged MS population in Barcelona, Spain. We started the recruitment of patients in the early phase of MS in 2010 and it remains permanently open. All patients undergo a complete neurological and ophthalmological examination including measurements of physical and disability (Expanded Disability Status Scale; Multiple Sclerosis Functional Composite and neuropsychological tests), disease activity (relapses) and visual function testing (visual acuity, color vision and visual field). The MS-VisualPath protocol also assesses the presence of anxiety and depressive symptoms (Hospital Anxiety and Depression Scale), general quality of life (SF-36) and visual quality of life (25-Item National Eye Institute Visual Function Questionnaire with the 10-Item Neuro-Ophthalmic Supplement). In addition, the imaging protocol includes both retinal (Optical Coherence Tomography and Wide-Field Fundus Imaging) and brain imaging (Magnetic Resonance Imaging). Finally, multifocal Visual Evoked Potentials are used to perform neurophysiological assessment of the visual pathway.

Discussion: The analysis of the visual pathway with advance imaging and electrophysilogical tools in parallel with clinical information will provide significant and new knowledge regarding neurodegeneration in MS and provide new clinical and imaging biomarkers to help monitor disease progression in these patients.

No MeSH data available.


Related in: MedlinePlus

Displays the flow-chart of participants. It shows the participants dropped during the recruitment process as well as those dropped during the follow-up.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
getmorefigures.php?uid=PMC4300678&req=5

Fig1: Displays the flow-chart of participants. It shows the participants dropped during the recruitment process as well as those dropped during the follow-up.

Mentions: The selection process begins by extracting names of potential participants from the electronic medical records (EMR) of the Hospital Clinic. The EMR are checked to corroborate that they meet study eligibility criteria. Candidates are approached during their clinical visits and if they show interest in enrolling in the cohort, an interview with the researcher is scheduled. The researcher explains the purpose, visits, and diagnostic tools included in the protocol. If the patient agrees to participate, he/she signs an informed consent and a screening ophthalmological visit is scheduled to evaluate if the participant fulfils the reliability criteria for OCT and visual fields. Most MS patients approached in this way agreed to enrol in the study (Figure 1). Baseline features of the participants are displayed in Table 1.Figure 1


The multiple sclerosis visual pathway cohort: understanding neurodegeneration in MS.

Martínez-Lapiscina EH, Fraga-Pumar E, Gabilondo I, Martínez-Heras E, Torres-Torres R, Ortiz-Pérez S, Llufriu S, Tercero A, Andorra M, Roca MF, Lampert E, Zubizarreta I, Saiz A, Sanchez-Dalmau B, Villoslada P - BMC Res Notes (2014)

Displays the flow-chart of participants. It shows the participants dropped during the recruitment process as well as those dropped during the follow-up.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4300678&req=5

Fig1: Displays the flow-chart of participants. It shows the participants dropped during the recruitment process as well as those dropped during the follow-up.
Mentions: The selection process begins by extracting names of potential participants from the electronic medical records (EMR) of the Hospital Clinic. The EMR are checked to corroborate that they meet study eligibility criteria. Candidates are approached during their clinical visits and if they show interest in enrolling in the cohort, an interview with the researcher is scheduled. The researcher explains the purpose, visits, and diagnostic tools included in the protocol. If the patient agrees to participate, he/she signs an informed consent and a screening ophthalmological visit is scheduled to evaluate if the participant fulfils the reliability criteria for OCT and visual fields. Most MS patients approached in this way agreed to enrol in the study (Figure 1). Baseline features of the participants are displayed in Table 1.Figure 1

Bottom Line: We started the recruitment of patients in the early phase of MS in 2010 and it remains permanently open.In addition, the imaging protocol includes both retinal (Optical Coherence Tomography and Wide-Field Fundus Imaging) and brain imaging (Magnetic Resonance Imaging).The analysis of the visual pathway with advance imaging and electrophysilogical tools in parallel with clinical information will provide significant and new knowledge regarding neurodegeneration in MS and provide new clinical and imaging biomarkers to help monitor disease progression in these patients.

View Article: PubMed Central - PubMed

Affiliation: Center of Neuroimmunology, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) - Hospital Clinic of Barcelona, Casanova 145, Planta 3A, 08036 Barcelona, Spain. pvilloslada@clinic.ub.es.

ABSTRACT

Background: Multiple Sclerosis (MS) is an immune-mediated disease of the Central Nervous System with two major underlying etiopathogenic processes: inflammation and neurodegeneration. The latter determines the prognosis of this disease. MS is the main cause of non-traumatic disability in middle-aged populations.

Findings: The MS-VisualPath Cohort was set up to study the neurodegenerative component of MS using advanced imaging techniques by focusing on analysis of the visual pathway in a middle-aged MS population in Barcelona, Spain. We started the recruitment of patients in the early phase of MS in 2010 and it remains permanently open. All patients undergo a complete neurological and ophthalmological examination including measurements of physical and disability (Expanded Disability Status Scale; Multiple Sclerosis Functional Composite and neuropsychological tests), disease activity (relapses) and visual function testing (visual acuity, color vision and visual field). The MS-VisualPath protocol also assesses the presence of anxiety and depressive symptoms (Hospital Anxiety and Depression Scale), general quality of life (SF-36) and visual quality of life (25-Item National Eye Institute Visual Function Questionnaire with the 10-Item Neuro-Ophthalmic Supplement). In addition, the imaging protocol includes both retinal (Optical Coherence Tomography and Wide-Field Fundus Imaging) and brain imaging (Magnetic Resonance Imaging). Finally, multifocal Visual Evoked Potentials are used to perform neurophysiological assessment of the visual pathway.

Discussion: The analysis of the visual pathway with advance imaging and electrophysilogical tools in parallel with clinical information will provide significant and new knowledge regarding neurodegeneration in MS and provide new clinical and imaging biomarkers to help monitor disease progression in these patients.

No MeSH data available.


Related in: MedlinePlus