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A patchless dissolving microneedle delivery system enabling rapid and efficient transdermal drug delivery.

Lahiji SF, Dangol M, Jung H - Sci Rep (2015)

Bottom Line: Dissolving microneedles (DMNs) are polymeric, microscopic needles that deliver encapsulated drugs in a minimally invasive manner.However, due to wide variations in skin elasticity and the amount of hair on the skin, the arrays fabricated on the patch are often not completely inserted and large amount of loaded materials are not delivered.Here, we report "Microlancer", a novel micropillar based system by which patients can self-administer DMNs and which would also be capable of achieving 97 ± 2% delivery efficiency of the loaded drugs regardless of skin type or the amount of hair on the skin in less than a second.

View Article: PubMed Central - PubMed

Affiliation: Department of Biotechnology, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul, 120-749, Korea.

ABSTRACT
Dissolving microneedles (DMNs) are polymeric, microscopic needles that deliver encapsulated drugs in a minimally invasive manner. Currently, DMN arrays are superimposed onto patches that facilitate their insertion into skin. However, due to wide variations in skin elasticity and the amount of hair on the skin, the arrays fabricated on the patch are often not completely inserted and large amount of loaded materials are not delivered. Here, we report "Microlancer", a novel micropillar based system by which patients can self-administer DMNs and which would also be capable of achieving 97 ± 2% delivery efficiency of the loaded drugs regardless of skin type or the amount of hair on the skin in less than a second.

Show MeSH
DMN injection into polyacrylamide gel.Complete insertion was achieved by 0.5 s, with a depth of approximately 650 μm.
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f2: DMN injection into polyacrylamide gel.Complete insertion was achieved by 0.5 s, with a depth of approximately 650 μm.

Mentions: In order to visually capture the mechanical performance of the Microlancer, the insertion of DMNs into a polyacrylamide gel was recorded using a high-speed camera. Although poly acrylamide gel does not fully mimic human skin, it is widely used due to its transparency and skin-like properties2932. The position of the DMN tip was tracked using microscopic calibration software by evaluating still photographs. The minimum insertion depth (50 μm) was chosen as representative depth for controlled insertion performed by the Microlancer. The whole process lasted approximately 0.5 s (Fig. 2).


A patchless dissolving microneedle delivery system enabling rapid and efficient transdermal drug delivery.

Lahiji SF, Dangol M, Jung H - Sci Rep (2015)

DMN injection into polyacrylamide gel.Complete insertion was achieved by 0.5 s, with a depth of approximately 650 μm.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4300505&req=5

f2: DMN injection into polyacrylamide gel.Complete insertion was achieved by 0.5 s, with a depth of approximately 650 μm.
Mentions: In order to visually capture the mechanical performance of the Microlancer, the insertion of DMNs into a polyacrylamide gel was recorded using a high-speed camera. Although poly acrylamide gel does not fully mimic human skin, it is widely used due to its transparency and skin-like properties2932. The position of the DMN tip was tracked using microscopic calibration software by evaluating still photographs. The minimum insertion depth (50 μm) was chosen as representative depth for controlled insertion performed by the Microlancer. The whole process lasted approximately 0.5 s (Fig. 2).

Bottom Line: Dissolving microneedles (DMNs) are polymeric, microscopic needles that deliver encapsulated drugs in a minimally invasive manner.However, due to wide variations in skin elasticity and the amount of hair on the skin, the arrays fabricated on the patch are often not completely inserted and large amount of loaded materials are not delivered.Here, we report "Microlancer", a novel micropillar based system by which patients can self-administer DMNs and which would also be capable of achieving 97 ± 2% delivery efficiency of the loaded drugs regardless of skin type or the amount of hair on the skin in less than a second.

View Article: PubMed Central - PubMed

Affiliation: Department of Biotechnology, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul, 120-749, Korea.

ABSTRACT
Dissolving microneedles (DMNs) are polymeric, microscopic needles that deliver encapsulated drugs in a minimally invasive manner. Currently, DMN arrays are superimposed onto patches that facilitate their insertion into skin. However, due to wide variations in skin elasticity and the amount of hair on the skin, the arrays fabricated on the patch are often not completely inserted and large amount of loaded materials are not delivered. Here, we report "Microlancer", a novel micropillar based system by which patients can self-administer DMNs and which would also be capable of achieving 97 ± 2% delivery efficiency of the loaded drugs regardless of skin type or the amount of hair on the skin in less than a second.

Show MeSH