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A patchless dissolving microneedle delivery system enabling rapid and efficient transdermal drug delivery.

Lahiji SF, Dangol M, Jung H - Sci Rep (2015)

Bottom Line: Dissolving microneedles (DMNs) are polymeric, microscopic needles that deliver encapsulated drugs in a minimally invasive manner.However, due to wide variations in skin elasticity and the amount of hair on the skin, the arrays fabricated on the patch are often not completely inserted and large amount of loaded materials are not delivered.Here, we report "Microlancer", a novel micropillar based system by which patients can self-administer DMNs and which would also be capable of achieving 97 ± 2% delivery efficiency of the loaded drugs regardless of skin type or the amount of hair on the skin in less than a second.

View Article: PubMed Central - PubMed

Affiliation: Department of Biotechnology, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul, 120-749, Korea.

ABSTRACT
Dissolving microneedles (DMNs) are polymeric, microscopic needles that deliver encapsulated drugs in a minimally invasive manner. Currently, DMN arrays are superimposed onto patches that facilitate their insertion into skin. However, due to wide variations in skin elasticity and the amount of hair on the skin, the arrays fabricated on the patch are often not completely inserted and large amount of loaded materials are not delivered. Here, we report "Microlancer", a novel micropillar based system by which patients can self-administer DMNs and which would also be capable of achieving 97 ± 2% delivery efficiency of the loaded drugs regardless of skin type or the amount of hair on the skin in less than a second.

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Related in: MedlinePlus

Schematic illustration of the Microlancer and its performance.(a) Main units of Microlancer. (b) A 3 × 3 DMN array with respect to the other components of the Microlancer. (c) The positioning of the hole and its alignment with the micropillar results in the physical detachment of the DMNs. A protective layer ensures that only DMNs, and not the surrounding layer, are detached from the main layer. (d) Activation of the system releases the micropillars and inserts the DMNs into the skin through the injector spring. (e) DMNs are fully inserted into the skin and immediately dissolved.
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f1: Schematic illustration of the Microlancer and its performance.(a) Main units of Microlancer. (b) A 3 × 3 DMN array with respect to the other components of the Microlancer. (c) The positioning of the hole and its alignment with the micropillar results in the physical detachment of the DMNs. A protective layer ensures that only DMNs, and not the surrounding layer, are detached from the main layer. (d) Activation of the system releases the micropillars and inserts the DMNs into the skin through the injector spring. (e) DMNs are fully inserted into the skin and immediately dissolved.

Mentions: The Microlancer is currently designed to utilize a 3 × 3 array of rounded micropillars (r = 250 μm) in order to insert DMNs into the epidermis and dermis layers of the skin (Fig. 1a). The necessary injection force is generated by thumb pressure applied along the axis of the system. In parallel, a spring also pushes the array of micropillars, in order to maintain the correct alignment of the array with respect to the skin (Supplementary Fig. S1). Upon completion of the injection, two extractor springs enable the retraction of the micropillars back into the Microlancer housing. The DMN insertion depth is completely controlled by a micropillar length alignment system. Thus, securing the correct height block inside the system controls the insertion depth of the DMNs (Fig. 1b).


A patchless dissolving microneedle delivery system enabling rapid and efficient transdermal drug delivery.

Lahiji SF, Dangol M, Jung H - Sci Rep (2015)

Schematic illustration of the Microlancer and its performance.(a) Main units of Microlancer. (b) A 3 × 3 DMN array with respect to the other components of the Microlancer. (c) The positioning of the hole and its alignment with the micropillar results in the physical detachment of the DMNs. A protective layer ensures that only DMNs, and not the surrounding layer, are detached from the main layer. (d) Activation of the system releases the micropillars and inserts the DMNs into the skin through the injector spring. (e) DMNs are fully inserted into the skin and immediately dissolved.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4300505&req=5

f1: Schematic illustration of the Microlancer and its performance.(a) Main units of Microlancer. (b) A 3 × 3 DMN array with respect to the other components of the Microlancer. (c) The positioning of the hole and its alignment with the micropillar results in the physical detachment of the DMNs. A protective layer ensures that only DMNs, and not the surrounding layer, are detached from the main layer. (d) Activation of the system releases the micropillars and inserts the DMNs into the skin through the injector spring. (e) DMNs are fully inserted into the skin and immediately dissolved.
Mentions: The Microlancer is currently designed to utilize a 3 × 3 array of rounded micropillars (r = 250 μm) in order to insert DMNs into the epidermis and dermis layers of the skin (Fig. 1a). The necessary injection force is generated by thumb pressure applied along the axis of the system. In parallel, a spring also pushes the array of micropillars, in order to maintain the correct alignment of the array with respect to the skin (Supplementary Fig. S1). Upon completion of the injection, two extractor springs enable the retraction of the micropillars back into the Microlancer housing. The DMN insertion depth is completely controlled by a micropillar length alignment system. Thus, securing the correct height block inside the system controls the insertion depth of the DMNs (Fig. 1b).

Bottom Line: Dissolving microneedles (DMNs) are polymeric, microscopic needles that deliver encapsulated drugs in a minimally invasive manner.However, due to wide variations in skin elasticity and the amount of hair on the skin, the arrays fabricated on the patch are often not completely inserted and large amount of loaded materials are not delivered.Here, we report "Microlancer", a novel micropillar based system by which patients can self-administer DMNs and which would also be capable of achieving 97 ± 2% delivery efficiency of the loaded drugs regardless of skin type or the amount of hair on the skin in less than a second.

View Article: PubMed Central - PubMed

Affiliation: Department of Biotechnology, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul, 120-749, Korea.

ABSTRACT
Dissolving microneedles (DMNs) are polymeric, microscopic needles that deliver encapsulated drugs in a minimally invasive manner. Currently, DMN arrays are superimposed onto patches that facilitate their insertion into skin. However, due to wide variations in skin elasticity and the amount of hair on the skin, the arrays fabricated on the patch are often not completely inserted and large amount of loaded materials are not delivered. Here, we report "Microlancer", a novel micropillar based system by which patients can self-administer DMNs and which would also be capable of achieving 97 ± 2% delivery efficiency of the loaded drugs regardless of skin type or the amount of hair on the skin in less than a second.

Show MeSH
Related in: MedlinePlus