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A "green" strategy to construct non-covalent, stable and bioactive coatings on porous MOF nanoparticles.

Agostoni V, Horcajada P, Noiray M, Malanga M, Aykaç A, Jicsinszky L, Vargas-Berenguel A, Semiramoth N, Daoud-Mahammed S, Nicolas V, Martineau C, Taulelle F, Vigneron J, Etcheberry A, Serre C, Gref R - Sci Rep (2015)

Bottom Line: Here we bring the proof of concept that the outer surface of porous nanoMOFs can be specifically functionalized in a rapid, biofriendly and non-covalent manner, leading to stable and versatile coatings.The coating procedure did not affect the nanoMOF porosity, crystallinity, adsorption and release abilities.The stable cyclodextrin-based coating was further functionalized with: i) targeting moieties to increase the nanoMOF interaction with specific receptors and ii) poly(ethylene glycol) chains to escape the immune system.

View Article: PubMed Central - PubMed

Affiliation: Institut Galien, Université Paris-Sud, UMR CNRS 8612, 92290 Chatenay Malabry, France.

ABSTRACT
Nanoparticles made of metal-organic frameworks (nanoMOFs) attract a growing interest in gas storage, separation, catalysis, sensing and more recently, biomedicine. Achieving stable, versatile coatings on highly porous nanoMOFs without altering their ability to adsorb molecules of interest represents today a major challenge. Here we bring the proof of concept that the outer surface of porous nanoMOFs can be specifically functionalized in a rapid, biofriendly and non-covalent manner, leading to stable and versatile coatings. Cyclodextrin molecules bearing strong iron complexing groups (phosphates) were firmly anchored to the nanoMOFs' surface, within only a few minutes, simply by incubation with aqueous nanoMOF suspensions. The coating procedure did not affect the nanoMOF porosity, crystallinity, adsorption and release abilities. The stable cyclodextrin-based coating was further functionalized with: i) targeting moieties to increase the nanoMOF interaction with specific receptors and ii) poly(ethylene glycol) chains to escape the immune system. These results pave the way towards the design of surface-engineered nanoMOFs of interest for applications in the field of targeted drug delivery, catalysis, separation and sensing.

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Related in: MedlinePlus

Reconstituted envelope of a MOF crystal coated with rhodamine-labelled CD-P and observed in a confocal microscope.Views from top (a) bottom (b) left (c) and right (d). To enable visualizing inside MOF, signal from the first layer was removed. Bar represents 10 μm.
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f2: Reconstituted envelope of a MOF crystal coated with rhodamine-labelled CD-P and observed in a confocal microscope.Views from top (a) bottom (b) left (c) and right (d). To enable visualizing inside MOF, signal from the first layer was removed. Bar represents 10 μm.

Mentions: The location of the coatings could be visualized in the particular case of larger MOF particles (>10 μm) which were surface-modified with CD-P-R. Optical sections were observed by confocal microscopy (Fig. 2). The CD-P-R molecules were only detected at the surface (depth compatible with the resolution of the confocal microscope, i.e. around 200 nm) of the large crystalline particles. Other examples are given in SI (II.9).


A "green" strategy to construct non-covalent, stable and bioactive coatings on porous MOF nanoparticles.

Agostoni V, Horcajada P, Noiray M, Malanga M, Aykaç A, Jicsinszky L, Vargas-Berenguel A, Semiramoth N, Daoud-Mahammed S, Nicolas V, Martineau C, Taulelle F, Vigneron J, Etcheberry A, Serre C, Gref R - Sci Rep (2015)

Reconstituted envelope of a MOF crystal coated with rhodamine-labelled CD-P and observed in a confocal microscope.Views from top (a) bottom (b) left (c) and right (d). To enable visualizing inside MOF, signal from the first layer was removed. Bar represents 10 μm.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4300503&req=5

f2: Reconstituted envelope of a MOF crystal coated with rhodamine-labelled CD-P and observed in a confocal microscope.Views from top (a) bottom (b) left (c) and right (d). To enable visualizing inside MOF, signal from the first layer was removed. Bar represents 10 μm.
Mentions: The location of the coatings could be visualized in the particular case of larger MOF particles (>10 μm) which were surface-modified with CD-P-R. Optical sections were observed by confocal microscopy (Fig. 2). The CD-P-R molecules were only detected at the surface (depth compatible with the resolution of the confocal microscope, i.e. around 200 nm) of the large crystalline particles. Other examples are given in SI (II.9).

Bottom Line: Here we bring the proof of concept that the outer surface of porous nanoMOFs can be specifically functionalized in a rapid, biofriendly and non-covalent manner, leading to stable and versatile coatings.The coating procedure did not affect the nanoMOF porosity, crystallinity, adsorption and release abilities.The stable cyclodextrin-based coating was further functionalized with: i) targeting moieties to increase the nanoMOF interaction with specific receptors and ii) poly(ethylene glycol) chains to escape the immune system.

View Article: PubMed Central - PubMed

Affiliation: Institut Galien, Université Paris-Sud, UMR CNRS 8612, 92290 Chatenay Malabry, France.

ABSTRACT
Nanoparticles made of metal-organic frameworks (nanoMOFs) attract a growing interest in gas storage, separation, catalysis, sensing and more recently, biomedicine. Achieving stable, versatile coatings on highly porous nanoMOFs without altering their ability to adsorb molecules of interest represents today a major challenge. Here we bring the proof of concept that the outer surface of porous nanoMOFs can be specifically functionalized in a rapid, biofriendly and non-covalent manner, leading to stable and versatile coatings. Cyclodextrin molecules bearing strong iron complexing groups (phosphates) were firmly anchored to the nanoMOFs' surface, within only a few minutes, simply by incubation with aqueous nanoMOF suspensions. The coating procedure did not affect the nanoMOF porosity, crystallinity, adsorption and release abilities. The stable cyclodextrin-based coating was further functionalized with: i) targeting moieties to increase the nanoMOF interaction with specific receptors and ii) poly(ethylene glycol) chains to escape the immune system. These results pave the way towards the design of surface-engineered nanoMOFs of interest for applications in the field of targeted drug delivery, catalysis, separation and sensing.

Show MeSH
Related in: MedlinePlus