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Anti-obesity and anti-hyperglycemic effects of cinnamaldehyde via altered ghrelin secretion and functional impact on food intake and gastric emptying.

Camacho S, Michlig S, de Senarclens-Bezençon C, Meylan J, Meystre J, Pezzoli M, Markram H, le Coutre J - Sci Rep (2015)

Bottom Line: Cinnamon extract is associated to different health benefits but the active ingredients or pathways are unknown.After receiving a single-dose of CIN, mice significantly reduce cumulative food intake and gastric emptying rates.Taken together, the results confirm anti-hyperglycemic and anti-obesity effects of CIN opening a new approach to investigate how certain spice derived compounds regulate endogenous ghrelin release for therapeutic intervention.

View Article: PubMed Central - PubMed

Affiliation: 1] Nestlé Research Center, Vers-chez-les-Blanc, Lausanne, Switzerland [2] Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.

ABSTRACT
Cinnamon extract is associated to different health benefits but the active ingredients or pathways are unknown. Cinnamaldehyde (CIN) imparts the characteristic flavor to cinnamon and is known to be the main agonist of transient receptor potential-ankyrin receptor 1 (TRPA1). Here, expression of TRPA1 in epithelial mouse stomach cells is described. After receiving a single-dose of CIN, mice significantly reduce cumulative food intake and gastric emptying rates. Co-localization of TRPA1 and ghrelin in enteroendocrine cells of the duodenum is observed both in vivo and in the MGN3-1 cell line, a ghrelin secreting cell model, where incubation with CIN up-regulates expression of TRPA1 and Insulin receptor genes. Ghrelin secreted in the culture medium was quantified following CIN stimulation and we observe that octanoyl and total ghrelin are significantly lower than in control conditions. Additionally, obese mice fed for five weeks with CIN-containing diet significantly reduce their cumulative body weight gain and improve glucose tolerance without detectable modification of insulin secretion. Finally, in adipose tissue up-regulation of genes related to fatty acid oxidation was observed. Taken together, the results confirm anti-hyperglycemic and anti-obesity effects of CIN opening a new approach to investigate how certain spice derived compounds regulate endogenous ghrelin release for therapeutic intervention.

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Related in: MedlinePlus

Effect of chronic intake of 0.2% CIN included in the diet of obese mice on daily food intake and body weight gain.0.2% of CIN was included in the high fat diet of DIO mice for a period of 5 weeks and body weight gain and food intake was measured daily. We did not observe any effect on food intake, whereas a significant effect on cumulative body weight gain was observed from day 24. (*, p<0.05; n = 33; error bars: SEM).
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f7: Effect of chronic intake of 0.2% CIN included in the diet of obese mice on daily food intake and body weight gain.0.2% of CIN was included in the high fat diet of DIO mice for a period of 5 weeks and body weight gain and food intake was measured daily. We did not observe any effect on food intake, whereas a significant effect on cumulative body weight gain was observed from day 24. (*, p<0.05; n = 33; error bars: SEM).

Mentions: To better understand the effect of CIN administrated in a chronic manner during 5 weeks, daily FI and BW were measured in DIO-mice fed with high fat food (60% of calories coming from fat) containing 0.2% of CIN. Contrary to the acute treatment, daily food intake was not affected by CIN (Fig. 7B) but surprisingly CIN had a significant impact reducing cumulative body weight gain starting at day 24 of treatment (Fig. 7A).


Anti-obesity and anti-hyperglycemic effects of cinnamaldehyde via altered ghrelin secretion and functional impact on food intake and gastric emptying.

Camacho S, Michlig S, de Senarclens-Bezençon C, Meylan J, Meystre J, Pezzoli M, Markram H, le Coutre J - Sci Rep (2015)

Effect of chronic intake of 0.2% CIN included in the diet of obese mice on daily food intake and body weight gain.0.2% of CIN was included in the high fat diet of DIO mice for a period of 5 weeks and body weight gain and food intake was measured daily. We did not observe any effect on food intake, whereas a significant effect on cumulative body weight gain was observed from day 24. (*, p<0.05; n = 33; error bars: SEM).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4300502&req=5

f7: Effect of chronic intake of 0.2% CIN included in the diet of obese mice on daily food intake and body weight gain.0.2% of CIN was included in the high fat diet of DIO mice for a period of 5 weeks and body weight gain and food intake was measured daily. We did not observe any effect on food intake, whereas a significant effect on cumulative body weight gain was observed from day 24. (*, p<0.05; n = 33; error bars: SEM).
Mentions: To better understand the effect of CIN administrated in a chronic manner during 5 weeks, daily FI and BW were measured in DIO-mice fed with high fat food (60% of calories coming from fat) containing 0.2% of CIN. Contrary to the acute treatment, daily food intake was not affected by CIN (Fig. 7B) but surprisingly CIN had a significant impact reducing cumulative body weight gain starting at day 24 of treatment (Fig. 7A).

Bottom Line: Cinnamon extract is associated to different health benefits but the active ingredients or pathways are unknown.After receiving a single-dose of CIN, mice significantly reduce cumulative food intake and gastric emptying rates.Taken together, the results confirm anti-hyperglycemic and anti-obesity effects of CIN opening a new approach to investigate how certain spice derived compounds regulate endogenous ghrelin release for therapeutic intervention.

View Article: PubMed Central - PubMed

Affiliation: 1] Nestlé Research Center, Vers-chez-les-Blanc, Lausanne, Switzerland [2] Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.

ABSTRACT
Cinnamon extract is associated to different health benefits but the active ingredients or pathways are unknown. Cinnamaldehyde (CIN) imparts the characteristic flavor to cinnamon and is known to be the main agonist of transient receptor potential-ankyrin receptor 1 (TRPA1). Here, expression of TRPA1 in epithelial mouse stomach cells is described. After receiving a single-dose of CIN, mice significantly reduce cumulative food intake and gastric emptying rates. Co-localization of TRPA1 and ghrelin in enteroendocrine cells of the duodenum is observed both in vivo and in the MGN3-1 cell line, a ghrelin secreting cell model, where incubation with CIN up-regulates expression of TRPA1 and Insulin receptor genes. Ghrelin secreted in the culture medium was quantified following CIN stimulation and we observe that octanoyl and total ghrelin are significantly lower than in control conditions. Additionally, obese mice fed for five weeks with CIN-containing diet significantly reduce their cumulative body weight gain and improve glucose tolerance without detectable modification of insulin secretion. Finally, in adipose tissue up-regulation of genes related to fatty acid oxidation was observed. Taken together, the results confirm anti-hyperglycemic and anti-obesity effects of CIN opening a new approach to investigate how certain spice derived compounds regulate endogenous ghrelin release for therapeutic intervention.

Show MeSH
Related in: MedlinePlus