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Phosphoproteomic analyses reveal novel cross-modulation mechanisms between two signaling pathways in yeast.

Vaga S, Bernardo-Faura M, Cokelaer T, Maiolica A, Barnes CA, Gillet LC, Hegemann B, van Drogen F, Sharifian H, Klipp E, Peter M, Saez-Rodriguez J, Aebersold R - Mol. Syst. Biol. (2014)

Bottom Line: We observed a pheromone-induced down-regulation of Hog1 phosphorylation due to Gpd1, Ste20, Ptp2, Pbs2, and Ptc1.Distinct Ste20 and Pbs2 phosphosites responded differently to the two stimuli, suggesting these proteins as key mediators of the information exchange.Our results show that the integration of the response to different stimuli requires complex interconnections between signaling pathways.

View Article: PubMed Central - PubMed

Affiliation: Department of Biology, Institute of Molecular Systems Biology ETH Zürich, Zürich, Switzerland.

No MeSH data available.


Related in: MedlinePlus

Modulation of Hog1 activation by pheromone and NaCl
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fig07: Modulation of Hog1 activation by pheromone and NaCl

Mentions: The down-regulation of ppHog1 (Figs5B and 7A) could have two sources: Either a Hog1 inhibitory component is activated or an activating component is down-regulated. Using the specificity matrices, we could now search our dataset for components that either directly or inversely follow the ppHog1 dynamic pattern. In the following, we present two possibilities that account for how pheromone could inactivate ppHog1.


Phosphoproteomic analyses reveal novel cross-modulation mechanisms between two signaling pathways in yeast.

Vaga S, Bernardo-Faura M, Cokelaer T, Maiolica A, Barnes CA, Gillet LC, Hegemann B, van Drogen F, Sharifian H, Klipp E, Peter M, Saez-Rodriguez J, Aebersold R - Mol. Syst. Biol. (2014)

Modulation of Hog1 activation by pheromone and NaCl
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4300490&req=5

fig07: Modulation of Hog1 activation by pheromone and NaCl
Mentions: The down-regulation of ppHog1 (Figs5B and 7A) could have two sources: Either a Hog1 inhibitory component is activated or an activating component is down-regulated. Using the specificity matrices, we could now search our dataset for components that either directly or inversely follow the ppHog1 dynamic pattern. In the following, we present two possibilities that account for how pheromone could inactivate ppHog1.

Bottom Line: We observed a pheromone-induced down-regulation of Hog1 phosphorylation due to Gpd1, Ste20, Ptp2, Pbs2, and Ptc1.Distinct Ste20 and Pbs2 phosphosites responded differently to the two stimuli, suggesting these proteins as key mediators of the information exchange.Our results show that the integration of the response to different stimuli requires complex interconnections between signaling pathways.

View Article: PubMed Central - PubMed

Affiliation: Department of Biology, Institute of Molecular Systems Biology ETH Zürich, Zürich, Switzerland.

No MeSH data available.


Related in: MedlinePlus