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Effect of s-methyl-L-cysteine on oxidative stress, inflammation and insulin resistance in male wistar rats fed with high fructose diet.

Thomas S, Senthilkumar GP, Sivaraman K, Bobby Z, Paneerselvam S, Harichandrakumar KT - Iran J Med Sci (2015)

Bottom Line: S-methyl cysteine (SMC) is a hydrophilic cysteine-containing compound naturally found in garlic and onion.The 60% fructose used for 8 weeks and SMC in the dose of 100 mg/kg bw/day/rat was used in the study.Oral administration of SMC (100 mg/kg bw/day/rat) for 60 days resulted in significant attenuation of plasma glucose, insulin, tumor necrosis factor-alpha, insulin resistance and improved antioxidant enzyme activities.

View Article: PubMed Central - PubMed

Affiliation: Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India;

ABSTRACT

Background: S-methyl cysteine (SMC) is a hydrophilic cysteine-containing compound naturally found in garlic and onion. The purpose of the present study was to investigate the protective effect of SMC on oxidative stress, inflammation and insulin resistance in an experiment of metabolic syndrome.

Methods: Male Wistar rats were divided into five groups (6 rats in each group), namely; control, control+S-methyl cysteine (SMC), high fructose diet (HFD), HFD+SMC and HFD+metformin. The 60% fructose used for 8 weeks and SMC in the dose of 100 mg/kg bw/day/rat was used in the study. The fasting glucose, insulin, insulin resistance, and tumor necrosis factor alpha and erythrocyte enzymatic antioxidants were measured.

Results: Increased levels of plasma glucose, insulin, malondialdehyde, tumor necrosis factor-alpha, and insulin resistance and decreased levels of glutathione, glutathione peroxidase, and catalase were found in rats on a high fructose diet. Oral administration of SMC (100 mg/kg bw/day/rat) for 60 days resulted in significant attenuation of plasma glucose, insulin, tumor necrosis factor-alpha, insulin resistance and improved antioxidant enzyme activities.

Conclusion: Oral treatment of SMC is effective in improving insulin resistance while attenuating metabolic syndrome, inflammation, and oxidative stress in male rats fed with fructose rich diet.

No MeSH data available.


Related in: MedlinePlus

Comparison of the level of TNF-α between the study groups. The TNF-α is significantly higher in HFD when compared with all other groups (P<0.05)
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Figure 1: Comparison of the level of TNF-α between the study groups. The TNF-α is significantly higher in HFD when compared with all other groups (P<0.05)

Mentions: The effect of SMC on the level of TNF-α between the study groups shows that TNF-α is significantly higher (P<0.05) among HFD induced rats when compared with other groups. The details on the analysis of TNF-α between the study groups is depicted in figure 1. A significant (P<0.05) decline in the levels of TNF-α was observed on oral administration of SMC as well as metformin.


Effect of s-methyl-L-cysteine on oxidative stress, inflammation and insulin resistance in male wistar rats fed with high fructose diet.

Thomas S, Senthilkumar GP, Sivaraman K, Bobby Z, Paneerselvam S, Harichandrakumar KT - Iran J Med Sci (2015)

Comparison of the level of TNF-α between the study groups. The TNF-α is significantly higher in HFD when compared with all other groups (P<0.05)
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4300480&req=5

Figure 1: Comparison of the level of TNF-α between the study groups. The TNF-α is significantly higher in HFD when compared with all other groups (P<0.05)
Mentions: The effect of SMC on the level of TNF-α between the study groups shows that TNF-α is significantly higher (P<0.05) among HFD induced rats when compared with other groups. The details on the analysis of TNF-α between the study groups is depicted in figure 1. A significant (P<0.05) decline in the levels of TNF-α was observed on oral administration of SMC as well as metformin.

Bottom Line: S-methyl cysteine (SMC) is a hydrophilic cysteine-containing compound naturally found in garlic and onion.The 60% fructose used for 8 weeks and SMC in the dose of 100 mg/kg bw/day/rat was used in the study.Oral administration of SMC (100 mg/kg bw/day/rat) for 60 days resulted in significant attenuation of plasma glucose, insulin, tumor necrosis factor-alpha, insulin resistance and improved antioxidant enzyme activities.

View Article: PubMed Central - PubMed

Affiliation: Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India;

ABSTRACT

Background: S-methyl cysteine (SMC) is a hydrophilic cysteine-containing compound naturally found in garlic and onion. The purpose of the present study was to investigate the protective effect of SMC on oxidative stress, inflammation and insulin resistance in an experiment of metabolic syndrome.

Methods: Male Wistar rats were divided into five groups (6 rats in each group), namely; control, control+S-methyl cysteine (SMC), high fructose diet (HFD), HFD+SMC and HFD+metformin. The 60% fructose used for 8 weeks and SMC in the dose of 100 mg/kg bw/day/rat was used in the study. The fasting glucose, insulin, insulin resistance, and tumor necrosis factor alpha and erythrocyte enzymatic antioxidants were measured.

Results: Increased levels of plasma glucose, insulin, malondialdehyde, tumor necrosis factor-alpha, and insulin resistance and decreased levels of glutathione, glutathione peroxidase, and catalase were found in rats on a high fructose diet. Oral administration of SMC (100 mg/kg bw/day/rat) for 60 days resulted in significant attenuation of plasma glucose, insulin, tumor necrosis factor-alpha, insulin resistance and improved antioxidant enzyme activities.

Conclusion: Oral treatment of SMC is effective in improving insulin resistance while attenuating metabolic syndrome, inflammation, and oxidative stress in male rats fed with fructose rich diet.

No MeSH data available.


Related in: MedlinePlus