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Nighttime aircraft noise impairs endothelial function and increases blood pressure in patients with or at high risk for coronary artery disease.

Schmidt F, Kolle K, Kreuder K, Schnorbus B, Wild P, Hechtner M, Binder H, Gori T, Münzel T - Clin Res Cardiol (2014)

Bottom Line: FMD was significantly reduced (from 9.6 ± 4.3 to 7.9 ± 3.7%; p < 0.001) and systolic blood pressure was increased (from 129.5 ± 16.5 to 133.6 ± 17.9 mmHg; p = 0.030) by noise.The adverse vascular effects of noise were independent from sleep quality and self-reported noise sensitivity.These vascular effects appear to be independent from annoyance and attitude towards noise and may explain in part the cardiovascular side effects of nighttime aircraft noise.

View Article: PubMed Central - PubMed

Affiliation: 2 Medical Clinic, Cardiology, University Medical Center Mainz, Johannes Gutenberg University, Langenbeckstrasse 1, 55131, Mainz, Germany.

ABSTRACT

Aims: Epidemiological studies suggest the existence of a relationship between aircraft noise exposure and increased risk for myocardial infarction and stroke. Patients with established coronary artery disease and endothelial dysfunction are known to have more future cardiovascular events. We therefore tested the effects of nocturnal aircraft noise on endothelial function in patients with or at high risk for coronary artery disease.

Methods: 60 Patients (50p 1-3 vessels disease; 10p with a high Framingham Score of 23%) were exposed in random and blinded order to aircraft noise and no noise conditions. Noise was simulated in the patients' bedroom and consisted of 60 events during one night. Polygraphy was recorded during study nights, endothelial function (flow-mediated dilation of the brachial artery), questionnaires and blood sampling were performed on the morning after each study night.

Results: The mean sound pressure levels L eq(3) measured were 46.9 ± 2.0 dB(A) in the Noise 60 nights and 39.2 ± 3.1 dB(A) in the control nights. Subjective sleep quality was markedly reduced by noise from 5.8 ± 2.0 to 3.7 ± 2.2 (p < 0.001). FMD was significantly reduced (from 9.6 ± 4.3 to 7.9 ± 3.7%; p < 0.001) and systolic blood pressure was increased (from 129.5 ± 16.5 to 133.6 ± 17.9 mmHg; p = 0.030) by noise. The adverse vascular effects of noise were independent from sleep quality and self-reported noise sensitivity.

Conclusions: Nighttime aircraft noise markedly impairs endothelial function in patients with or at risk for cardiovascular disease. These vascular effects appear to be independent from annoyance and attitude towards noise and may explain in part the cardiovascular side effects of nighttime aircraft noise.

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Related in: MedlinePlus

Influence of patient factors on flow-mediated dilation (FMD). a Subjective sleep quality (in cm as measured in the source data, higher values correspond to worse sleep quality; cumulative transformed data on a 0–10 scale are reported in Table 2) does not exhibit a significant correlation with FMD values. b Global noise sensitivity and c sleep related noise sensitivity as assessed by the Dortmund Noise Sensitivity Questionnaire (NoiSeQ) do not modify the effect of noise exposure on endothelial function (FMD). d Likewise patient attitude towards air traffic and aircraft noise does not predict the effect of noise simulation on the primary endpoint. Data are mean ±2 standard errors. Categories including n < 5 are not presented
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Fig2: Influence of patient factors on flow-mediated dilation (FMD). a Subjective sleep quality (in cm as measured in the source data, higher values correspond to worse sleep quality; cumulative transformed data on a 0–10 scale are reported in Table 2) does not exhibit a significant correlation with FMD values. b Global noise sensitivity and c sleep related noise sensitivity as assessed by the Dortmund Noise Sensitivity Questionnaire (NoiSeQ) do not modify the effect of noise exposure on endothelial function (FMD). d Likewise patient attitude towards air traffic and aircraft noise does not predict the effect of noise simulation on the primary endpoint. Data are mean ±2 standard errors. Categories including n < 5 are not presented

Mentions: In the linear mixed models, the response of participants’ endothelial function was not associated with overall noise sensitivity (NoiSeQ), sleep related noise sensitivity or attitude towards aircraft noise (Fig. 2).Fig. 2


Nighttime aircraft noise impairs endothelial function and increases blood pressure in patients with or at high risk for coronary artery disease.

Schmidt F, Kolle K, Kreuder K, Schnorbus B, Wild P, Hechtner M, Binder H, Gori T, Münzel T - Clin Res Cardiol (2014)

Influence of patient factors on flow-mediated dilation (FMD). a Subjective sleep quality (in cm as measured in the source data, higher values correspond to worse sleep quality; cumulative transformed data on a 0–10 scale are reported in Table 2) does not exhibit a significant correlation with FMD values. b Global noise sensitivity and c sleep related noise sensitivity as assessed by the Dortmund Noise Sensitivity Questionnaire (NoiSeQ) do not modify the effect of noise exposure on endothelial function (FMD). d Likewise patient attitude towards air traffic and aircraft noise does not predict the effect of noise simulation on the primary endpoint. Data are mean ±2 standard errors. Categories including n < 5 are not presented
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4300412&req=5

Fig2: Influence of patient factors on flow-mediated dilation (FMD). a Subjective sleep quality (in cm as measured in the source data, higher values correspond to worse sleep quality; cumulative transformed data on a 0–10 scale are reported in Table 2) does not exhibit a significant correlation with FMD values. b Global noise sensitivity and c sleep related noise sensitivity as assessed by the Dortmund Noise Sensitivity Questionnaire (NoiSeQ) do not modify the effect of noise exposure on endothelial function (FMD). d Likewise patient attitude towards air traffic and aircraft noise does not predict the effect of noise simulation on the primary endpoint. Data are mean ±2 standard errors. Categories including n < 5 are not presented
Mentions: In the linear mixed models, the response of participants’ endothelial function was not associated with overall noise sensitivity (NoiSeQ), sleep related noise sensitivity or attitude towards aircraft noise (Fig. 2).Fig. 2

Bottom Line: FMD was significantly reduced (from 9.6 ± 4.3 to 7.9 ± 3.7%; p < 0.001) and systolic blood pressure was increased (from 129.5 ± 16.5 to 133.6 ± 17.9 mmHg; p = 0.030) by noise.The adverse vascular effects of noise were independent from sleep quality and self-reported noise sensitivity.These vascular effects appear to be independent from annoyance and attitude towards noise and may explain in part the cardiovascular side effects of nighttime aircraft noise.

View Article: PubMed Central - PubMed

Affiliation: 2 Medical Clinic, Cardiology, University Medical Center Mainz, Johannes Gutenberg University, Langenbeckstrasse 1, 55131, Mainz, Germany.

ABSTRACT

Aims: Epidemiological studies suggest the existence of a relationship between aircraft noise exposure and increased risk for myocardial infarction and stroke. Patients with established coronary artery disease and endothelial dysfunction are known to have more future cardiovascular events. We therefore tested the effects of nocturnal aircraft noise on endothelial function in patients with or at high risk for coronary artery disease.

Methods: 60 Patients (50p 1-3 vessels disease; 10p with a high Framingham Score of 23%) were exposed in random and blinded order to aircraft noise and no noise conditions. Noise was simulated in the patients' bedroom and consisted of 60 events during one night. Polygraphy was recorded during study nights, endothelial function (flow-mediated dilation of the brachial artery), questionnaires and blood sampling were performed on the morning after each study night.

Results: The mean sound pressure levels L eq(3) measured were 46.9 ± 2.0 dB(A) in the Noise 60 nights and 39.2 ± 3.1 dB(A) in the control nights. Subjective sleep quality was markedly reduced by noise from 5.8 ± 2.0 to 3.7 ± 2.2 (p < 0.001). FMD was significantly reduced (from 9.6 ± 4.3 to 7.9 ± 3.7%; p < 0.001) and systolic blood pressure was increased (from 129.5 ± 16.5 to 133.6 ± 17.9 mmHg; p = 0.030) by noise. The adverse vascular effects of noise were independent from sleep quality and self-reported noise sensitivity.

Conclusions: Nighttime aircraft noise markedly impairs endothelial function in patients with or at risk for cardiovascular disease. These vascular effects appear to be independent from annoyance and attitude towards noise and may explain in part the cardiovascular side effects of nighttime aircraft noise.

Show MeSH
Related in: MedlinePlus