Spinally projecting preproglucagon axons preferentially innervate sympathetic preganglionic neurons.
Bottom Line: These results show that brainstem PPG neurons innervate spinal autonomic and somatic motor neurons.SPN receive the densest PPG innervation.Brainstem PPG neurons could directly modulate sympathetic outflow through their spinal inputs to SPN or interneurons.
Affiliation: Cardiovascular Medicine, Physiology and Centre for Neuroscience, Flinders University, Bedford Park, SA 5042, Australia.Show MeSH
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Mentions: In the LE, YFP-immunoreactive boutons formed close appositions on the somata or proximal dendrites of a subset of the spinal neurons that contained YFP (Fig. 9A–D). To assess the extent of this innervation, we counted YFP-immunoreactive neurons that were and were not apposed by YFP-immunoreactive axons in transverse sections that were stained for YFP and either ChAT or NOS from seven YFP-PPG mice. Of the 195 YFP-expressing spinal neurons examined, 40 (20.5%) received close appositions from YFP-immunoreactive terminals.
Affiliation: Cardiovascular Medicine, Physiology and Centre for Neuroscience, Flinders University, Bedford Park, SA 5042, Australia.