Spinally projecting preproglucagon axons preferentially innervate sympathetic preganglionic neurons.
Bottom Line: These results show that brainstem PPG neurons innervate spinal autonomic and somatic motor neurons.SPN receive the densest PPG innervation.Brainstem PPG neurons could directly modulate sympathetic outflow through their spinal inputs to SPN or interneurons.
Affiliation: Cardiovascular Medicine, Physiology and Centre for Neuroscience, Flinders University, Bedford Park, SA 5042, Australia.Show MeSH
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Mentions: In both transverse (Fig. 4) and horizontal (Fig. 5) sections, it was clear that the YFP innervation of the CAA was considerably more dense than the YFP innervation of either the IML or the ICN. There were also YFP-immunoreactive axons in the dorsolateral and lateral funiculi (Figs. 4A–E and 5A, B). Many of the varicose YFP-immunoreactive axons in the IML and ICN in spinal segments T1–L2 closely apposed the cell bodies and proximal dendrites of ChAT-immunoreactive SPN (Fig. 4A, B, E and F). Similarly, varicose YFP-positive axons in dorsal lamina X often formed close appositions on ChAT-positive SPN perikarya in the CAA (Figs. 4G, H and 5D–F). In both the IML and CAA, some ChAT-positive neurons received more than one apposition from YFP-immunoreactive terminals. This was particularly the case for SPN that lay within dense arrays of YFP-positive axons (Fig. 4B, H).
Affiliation: Cardiovascular Medicine, Physiology and Centre for Neuroscience, Flinders University, Bedford Park, SA 5042, Australia.