Spinally projecting preproglucagon axons preferentially innervate sympathetic preganglionic neurons.
Bottom Line: These results show that brainstem PPG neurons innervate spinal autonomic and somatic motor neurons.SPN receive the densest PPG innervation.Brainstem PPG neurons could directly modulate sympathetic outflow through their spinal inputs to SPN or interneurons.
Affiliation: Cardiovascular Medicine, Physiology and Centre for Neuroscience, Flinders University, Bedford Park, SA 5042, Australia.Show MeSH
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Mentions: The distribution of glucagon promoter-driven YFP expression in coronal and longitudinal sections of spinal cord between thoracic segment 1 (T1) and sacral segment 4 (S4) was assessed in seven adult YFP-PPG mice. ‘Native’ YFP-fluorescence was strong and both YFP-fluorescent axons and cell bodies could be identified without immunostaining (Fig. 1), as has been observed in brainstem (Hisadome et al., 2010; Llewellyn-Smith et al., 2011).
Affiliation: Cardiovascular Medicine, Physiology and Centre for Neuroscience, Flinders University, Bedford Park, SA 5042, Australia.