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Surgical and localized radiation therapy for an intranasal adenocarcinoma in a rabbit.

Nakata M, Miwa Y, Tsuboi M, Uchida K - J. Vet. Med. Sci. (2014)

Bottom Line: Surgical exenteration of the lesions was performed, and the histopathological diagnosis was an intranasal adenocarcinoma.The prognosis has remained good for over 3 years after treatment.This paper is the first to describe the clinical and pathological features of an intranasal tumor in a rabbit.

View Article: PubMed Central - PubMed

Affiliation: Miwa Exotic Animal Hospital, 1-25-5 Komagome, Toshima-ku, 170-0003 Tokyo, Japan.

ABSTRACT
An 8-year-old spayed female Netherland Dwarf rabbit presented with a two-month history of dyspnea and snoring. A computed tomography (CT) scan of the head revealed mass lesions in the right nasal cavity. Surgical exenteration of the lesions was performed, and the histopathological diagnosis was an intranasal adenocarcinoma. On the basis of this diagnosis, radiotherapy was planned and consisted of eight fractions of 6 Gy administered once a week. After the completion of radiation therapy, the soft tissue density in the right nasal cavity, as detected by CT, significantly decreased. The prognosis has remained good for over 3 years after treatment. This paper is the first to describe the clinical and pathological features of an intranasal tumor in a rabbit.

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Histopathological findings of the intranasal mass. Glandular proliferation of atypicalcolumnar cells with severe lymphocytic infiltration and interstitial hemorrhage wasobserved. Hematoxylin and Eosin stain. Bar=100 µm.
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fig_003: Histopathological findings of the intranasal mass. Glandular proliferation of atypicalcolumnar cells with severe lymphocytic infiltration and interstitial hemorrhage wasobserved. Hematoxylin and Eosin stain. Bar=100 µm.

Mentions: Histopathological evaluation of the nasal tissues revealed a glandular proliferation ofatypical columnar epithelial cells with severe lymphocytic infiltration and interstitialhemorrhage. Tumor cells had clear to slightly eosinophilic cytoplasm and a pale oval nucleuswith mild anisokaryosis. Nucleoli were prominent in occasional tumor cells, and there were 1to 2 mitotic figures per 400× field. Based on the histopathological findings, the diagnosiswas an intranasal adenocarcinoma (Fig. 3Fig. 3.


Surgical and localized radiation therapy for an intranasal adenocarcinoma in a rabbit.

Nakata M, Miwa Y, Tsuboi M, Uchida K - J. Vet. Med. Sci. (2014)

Histopathological findings of the intranasal mass. Glandular proliferation of atypicalcolumnar cells with severe lymphocytic infiltration and interstitial hemorrhage wasobserved. Hematoxylin and Eosin stain. Bar=100 µm.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4300386&req=5

fig_003: Histopathological findings of the intranasal mass. Glandular proliferation of atypicalcolumnar cells with severe lymphocytic infiltration and interstitial hemorrhage wasobserved. Hematoxylin and Eosin stain. Bar=100 µm.
Mentions: Histopathological evaluation of the nasal tissues revealed a glandular proliferation ofatypical columnar epithelial cells with severe lymphocytic infiltration and interstitialhemorrhage. Tumor cells had clear to slightly eosinophilic cytoplasm and a pale oval nucleuswith mild anisokaryosis. Nucleoli were prominent in occasional tumor cells, and there were 1to 2 mitotic figures per 400× field. Based on the histopathological findings, the diagnosiswas an intranasal adenocarcinoma (Fig. 3Fig. 3.

Bottom Line: Surgical exenteration of the lesions was performed, and the histopathological diagnosis was an intranasal adenocarcinoma.The prognosis has remained good for over 3 years after treatment.This paper is the first to describe the clinical and pathological features of an intranasal tumor in a rabbit.

View Article: PubMed Central - PubMed

Affiliation: Miwa Exotic Animal Hospital, 1-25-5 Komagome, Toshima-ku, 170-0003 Tokyo, Japan.

ABSTRACT
An 8-year-old spayed female Netherland Dwarf rabbit presented with a two-month history of dyspnea and snoring. A computed tomography (CT) scan of the head revealed mass lesions in the right nasal cavity. Surgical exenteration of the lesions was performed, and the histopathological diagnosis was an intranasal adenocarcinoma. On the basis of this diagnosis, radiotherapy was planned and consisted of eight fractions of 6 Gy administered once a week. After the completion of radiation therapy, the soft tissue density in the right nasal cavity, as detected by CT, significantly decreased. The prognosis has remained good for over 3 years after treatment. This paper is the first to describe the clinical and pathological features of an intranasal tumor in a rabbit.

Show MeSH
Related in: MedlinePlus