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Systemic mycobacteriosis in an aborted thoroughbred fetus in Japan.

Sano Y, Matsuda K, Osaki K, Miyasho T, Tsuda T, Taniyama H - J. Vet. Med. Sci. (2014)

Bottom Line: A male Thoroughbred fetus was aborted on day 251 of pregnancy.Gross and histological examinations detected systemic granulomatous lesions in many superficial and visceral lymph nodes and organs including the liver, tonsils, lungs, thymus, spleen, right thyroid gland and gastrointestinal tract, and suppurative placentitis, pyogranulomatous amnionitis and intralesional acid-fast bacilli were also detected.An examination of the DNA base sequence of the β subunit of RNA polymerase demonstrated that Mycobacterium avium strain 104 had infected several organs.

View Article: PubMed Central - PubMed

Affiliation: Department of Veterinary Pathology, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069-8501, Japan.

ABSTRACT
A male Thoroughbred fetus was aborted on day 251 of pregnancy. Gross and histological examinations detected systemic granulomatous lesions in many superficial and visceral lymph nodes and organs including the liver, tonsils, lungs, thymus, spleen, right thyroid gland and gastrointestinal tract, and suppurative placentitis, pyogranulomatous amnionitis and intralesional acid-fast bacilli were also detected. An examination of the DNA base sequence of the β subunit of RNA polymerase demonstrated that Mycobacterium avium strain 104 had infected several organs. To the best of our knowledge, this is the first report of equine fetal mycobacterial infection in Japan.

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Related in: MedlinePlus

Higher magnification image of the granulomatous lesion in the cranial mesenteric lymphnode. The lesion is composed of epithelioid macrophages, multinucleated giant cells andneutrophils admixed with prominent fibrous tissue, which exhibits a sarcomatousappearance. HE. Bar=100 µm. (Inset) Numerous acid-fast staining bacilliare detected within the cytoplasm of the epithelioid macrophages and multinucleatedgiant cells. Ziehl-Neelsen. Bar=20 µm.
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fig_005: Higher magnification image of the granulomatous lesion in the cranial mesenteric lymphnode. The lesion is composed of epithelioid macrophages, multinucleated giant cells andneutrophils admixed with prominent fibrous tissue, which exhibits a sarcomatousappearance. HE. Bar=100 µm. (Inset) Numerous acid-fast staining bacilliare detected within the cytoplasm of the epithelioid macrophages and multinucleatedgiant cells. Ziehl-Neelsen. Bar=20 µm.

Mentions: The cranial mesenteric lymph node has been replaced by a diffuse granulomatous lesioncontaining necrotic foci (N). HE. Bar=500 µm.


Systemic mycobacteriosis in an aborted thoroughbred fetus in Japan.

Sano Y, Matsuda K, Osaki K, Miyasho T, Tsuda T, Taniyama H - J. Vet. Med. Sci. (2014)

Higher magnification image of the granulomatous lesion in the cranial mesenteric lymphnode. The lesion is composed of epithelioid macrophages, multinucleated giant cells andneutrophils admixed with prominent fibrous tissue, which exhibits a sarcomatousappearance. HE. Bar=100 µm. (Inset) Numerous acid-fast staining bacilliare detected within the cytoplasm of the epithelioid macrophages and multinucleatedgiant cells. Ziehl-Neelsen. Bar=20 µm.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4300377&req=5

fig_005: Higher magnification image of the granulomatous lesion in the cranial mesenteric lymphnode. The lesion is composed of epithelioid macrophages, multinucleated giant cells andneutrophils admixed with prominent fibrous tissue, which exhibits a sarcomatousappearance. HE. Bar=100 µm. (Inset) Numerous acid-fast staining bacilliare detected within the cytoplasm of the epithelioid macrophages and multinucleatedgiant cells. Ziehl-Neelsen. Bar=20 µm.
Mentions: The cranial mesenteric lymph node has been replaced by a diffuse granulomatous lesioncontaining necrotic foci (N). HE. Bar=500 µm.

Bottom Line: A male Thoroughbred fetus was aborted on day 251 of pregnancy.Gross and histological examinations detected systemic granulomatous lesions in many superficial and visceral lymph nodes and organs including the liver, tonsils, lungs, thymus, spleen, right thyroid gland and gastrointestinal tract, and suppurative placentitis, pyogranulomatous amnionitis and intralesional acid-fast bacilli were also detected.An examination of the DNA base sequence of the β subunit of RNA polymerase demonstrated that Mycobacterium avium strain 104 had infected several organs.

View Article: PubMed Central - PubMed

Affiliation: Department of Veterinary Pathology, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069-8501, Japan.

ABSTRACT
A male Thoroughbred fetus was aborted on day 251 of pregnancy. Gross and histological examinations detected systemic granulomatous lesions in many superficial and visceral lymph nodes and organs including the liver, tonsils, lungs, thymus, spleen, right thyroid gland and gastrointestinal tract, and suppurative placentitis, pyogranulomatous amnionitis and intralesional acid-fast bacilli were also detected. An examination of the DNA base sequence of the β subunit of RNA polymerase demonstrated that Mycobacterium avium strain 104 had infected several organs. To the best of our knowledge, this is the first report of equine fetal mycobacterial infection in Japan.

Show MeSH
Related in: MedlinePlus