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Effects of surgical wound infiltration with bupivacaine on postoperative analgesia in cats undergoing bilateral mastectomy.

Yilmaz ÖT, Toydemir TS, Kirşan İ, Dokuzeylul B, Gunay Z, Karacam E - J. Vet. Med. Sci. (2014)

Bottom Line: In order to examine the behavioral changes associated with acute pain, a questionnaire was prepared and given to the owners to be completed 4 hr and then 10 hr after the operation.No significant difference was found at 10 hr after the operation between the groups.In conclusion, wound infiltration with bupivacaine before incisional closure provided reliable analgesia at least 4 hr after bilateral radical mastectomy in cats.

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics and Gynaecology, Faculty of Veterinary Medicine, Istanbul University, Avcılar, 34320, Istanbul, Turkey.

ABSTRACT
The analgesic effect of wound infiltration with bupivacaine was evaluated in cats undergoing bilateral mastectomy. Twenty-one female cats with mammary gland tumors were anesthetized with propofol and oxygen-isoflurane anesthesia following premedication with atropine. In the trial group (Group I; n=11), 30 ml of saline containing 2 mg/kg of bupivacaine was infiltrated topically into the surgical wound right after removal of the mammary glands, whereas only saline solution was infiltrated in the control group (Group II; n=10). At the same time, carprofen (4 mg/kg) was also administered subcutaneously in both groups. Behavioral signs of pain were monitored during the recovery period after general anesthesia. In order to examine the behavioral changes associated with acute pain, a questionnaire was prepared and given to the owners to be completed 4 hr and then 10 hr after the operation. According to the owners' anwers to the questionnaire, a pain score was specified using a "numerical rating scale" for each cat. Although some cats showed mild to moderate pain, the pain score recorded at 4 hr after the operation was significantly lower in Group I (P<0.001). No significant difference was found at 10 hr after the operation between the groups. The incidence of vocalization, aggression and convulsion within 2 hr after the operation was also lower in Group I. In conclusion, wound infiltration with bupivacaine before incisional closure provided reliable analgesia at least 4 hr after bilateral radical mastectomy in cats.

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Mean pain scores for the groups at 4 and 10 hr after the operation. Significantdifference between the groups: *P<0.001.
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fig_003: Mean pain scores for the groups at 4 and 10 hr after the operation. Significantdifference between the groups: *P<0.001.

Mentions: Urination was first observed at 10 ± 1.2 hr and 11 ± 1 hr after surgery in Group I andGroup II, respectively. Defecation was first observed at 22 ± 3 hr and 25 ± 2 hr aftersurgery in Group I and Group II, respectively. Voluntary eating was observed at 12 ± 2 hrand 26 ± 2 hr after surgery in Group I and Group II, respectively. The time at which eatingwas first observed was statistically earlier in Group I than in Group II(P<0.05). Mean pain scores for the groups are presented in Fig. 3Fig. 3.


Effects of surgical wound infiltration with bupivacaine on postoperative analgesia in cats undergoing bilateral mastectomy.

Yilmaz ÖT, Toydemir TS, Kirşan İ, Dokuzeylul B, Gunay Z, Karacam E - J. Vet. Med. Sci. (2014)

Mean pain scores for the groups at 4 and 10 hr after the operation. Significantdifference between the groups: *P<0.001.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4300374&req=5

fig_003: Mean pain scores for the groups at 4 and 10 hr after the operation. Significantdifference between the groups: *P<0.001.
Mentions: Urination was first observed at 10 ± 1.2 hr and 11 ± 1 hr after surgery in Group I andGroup II, respectively. Defecation was first observed at 22 ± 3 hr and 25 ± 2 hr aftersurgery in Group I and Group II, respectively. Voluntary eating was observed at 12 ± 2 hrand 26 ± 2 hr after surgery in Group I and Group II, respectively. The time at which eatingwas first observed was statistically earlier in Group I than in Group II(P<0.05). Mean pain scores for the groups are presented in Fig. 3Fig. 3.

Bottom Line: In order to examine the behavioral changes associated with acute pain, a questionnaire was prepared and given to the owners to be completed 4 hr and then 10 hr after the operation.No significant difference was found at 10 hr after the operation between the groups.In conclusion, wound infiltration with bupivacaine before incisional closure provided reliable analgesia at least 4 hr after bilateral radical mastectomy in cats.

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics and Gynaecology, Faculty of Veterinary Medicine, Istanbul University, Avcılar, 34320, Istanbul, Turkey.

ABSTRACT
The analgesic effect of wound infiltration with bupivacaine was evaluated in cats undergoing bilateral mastectomy. Twenty-one female cats with mammary gland tumors were anesthetized with propofol and oxygen-isoflurane anesthesia following premedication with atropine. In the trial group (Group I; n=11), 30 ml of saline containing 2 mg/kg of bupivacaine was infiltrated topically into the surgical wound right after removal of the mammary glands, whereas only saline solution was infiltrated in the control group (Group II; n=10). At the same time, carprofen (4 mg/kg) was also administered subcutaneously in both groups. Behavioral signs of pain were monitored during the recovery period after general anesthesia. In order to examine the behavioral changes associated with acute pain, a questionnaire was prepared and given to the owners to be completed 4 hr and then 10 hr after the operation. According to the owners' anwers to the questionnaire, a pain score was specified using a "numerical rating scale" for each cat. Although some cats showed mild to moderate pain, the pain score recorded at 4 hr after the operation was significantly lower in Group I (P<0.001). No significant difference was found at 10 hr after the operation between the groups. The incidence of vocalization, aggression and convulsion within 2 hr after the operation was also lower in Group I. In conclusion, wound infiltration with bupivacaine before incisional closure provided reliable analgesia at least 4 hr after bilateral radical mastectomy in cats.

Show MeSH
Related in: MedlinePlus