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Effects of surgical wound infiltration with bupivacaine on postoperative analgesia in cats undergoing bilateral mastectomy.

Yilmaz ÖT, Toydemir TS, Kirşan İ, Dokuzeylul B, Gunay Z, Karacam E - J. Vet. Med. Sci. (2014)

Bottom Line: In order to examine the behavioral changes associated with acute pain, a questionnaire was prepared and given to the owners to be completed 4 hr and then 10 hr after the operation.No significant difference was found at 10 hr after the operation between the groups.In conclusion, wound infiltration with bupivacaine before incisional closure provided reliable analgesia at least 4 hr after bilateral radical mastectomy in cats.

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics and Gynaecology, Faculty of Veterinary Medicine, Istanbul University, Avcılar, 34320, Istanbul, Turkey.

ABSTRACT
The analgesic effect of wound infiltration with bupivacaine was evaluated in cats undergoing bilateral mastectomy. Twenty-one female cats with mammary gland tumors were anesthetized with propofol and oxygen-isoflurane anesthesia following premedication with atropine. In the trial group (Group I; n=11), 30 ml of saline containing 2 mg/kg of bupivacaine was infiltrated topically into the surgical wound right after removal of the mammary glands, whereas only saline solution was infiltrated in the control group (Group II; n=10). At the same time, carprofen (4 mg/kg) was also administered subcutaneously in both groups. Behavioral signs of pain were monitored during the recovery period after general anesthesia. In order to examine the behavioral changes associated with acute pain, a questionnaire was prepared and given to the owners to be completed 4 hr and then 10 hr after the operation. According to the owners' anwers to the questionnaire, a pain score was specified using a "numerical rating scale" for each cat. Although some cats showed mild to moderate pain, the pain score recorded at 4 hr after the operation was significantly lower in Group I (P<0.001). No significant difference was found at 10 hr after the operation between the groups. The incidence of vocalization, aggression and convulsion within 2 hr after the operation was also lower in Group I. In conclusion, wound infiltration with bupivacaine before incisional closure provided reliable analgesia at least 4 hr after bilateral radical mastectomy in cats.

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Irrigation solution was administered to the surgical area through an impregnatedgauze after the removal of the mammary glands.
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fig_001: Irrigation solution was administered to the surgical area through an impregnatedgauze after the removal of the mammary glands.

Mentions: Anesthesia and Surgery: The cats were fasted for 10–12 hr prior tosurgery. In all cases, 0.04 mg/kg intramuscular atropine sulphate (Atropin®;Vetas, Istanbul, Turkey) was administered as a pre-medicant, and 4–6 mg/kg intravenouspropofol (Pofol®; Dongkook, Seoul, South Korea) was used for the induction ofanesthesia. General anesthesia was maintained with isoflurane (Isoflurane®;Rhodia Organique, Bristol, U.K.) in oxygen delivered via an endotracheal tube. Fluid therapywas administered during anesthesia using Lactated Ringer’s solution (Laktatlı Ringer Sol.500 ml, I.E. Ulagay, Istanbul, Turkey) at 3 ml/kg/hr asrecommended by Davis et al.[3]. Theoperations were performed by the same surgeon in this study. The cats were randomly dividedinto two groups. In the trial group (Group I) (n=11), after removal of the mammary glands, apour-on analgesia was administered to the surgical area with 30 ml ofsterile saline (Izotonik Sol. 100 ml, Eczacıbaşı Baxter, Istanbul, Turkey)containing 2 mg/kg bupivacaine (Marcaine® 0.5%; AstraZeneca, Istanbul, Turkey)solution, whereas in the control group (Group II) (n=10), only 30 ml salinewas used. The solution was kept on the area for at least 5 min on a sterile gauze (Fig. 1Fig. 1.


Effects of surgical wound infiltration with bupivacaine on postoperative analgesia in cats undergoing bilateral mastectomy.

Yilmaz ÖT, Toydemir TS, Kirşan İ, Dokuzeylul B, Gunay Z, Karacam E - J. Vet. Med. Sci. (2014)

Irrigation solution was administered to the surgical area through an impregnatedgauze after the removal of the mammary glands.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4300374&req=5

fig_001: Irrigation solution was administered to the surgical area through an impregnatedgauze after the removal of the mammary glands.
Mentions: Anesthesia and Surgery: The cats were fasted for 10–12 hr prior tosurgery. In all cases, 0.04 mg/kg intramuscular atropine sulphate (Atropin®;Vetas, Istanbul, Turkey) was administered as a pre-medicant, and 4–6 mg/kg intravenouspropofol (Pofol®; Dongkook, Seoul, South Korea) was used for the induction ofanesthesia. General anesthesia was maintained with isoflurane (Isoflurane®;Rhodia Organique, Bristol, U.K.) in oxygen delivered via an endotracheal tube. Fluid therapywas administered during anesthesia using Lactated Ringer’s solution (Laktatlı Ringer Sol.500 ml, I.E. Ulagay, Istanbul, Turkey) at 3 ml/kg/hr asrecommended by Davis et al.[3]. Theoperations were performed by the same surgeon in this study. The cats were randomly dividedinto two groups. In the trial group (Group I) (n=11), after removal of the mammary glands, apour-on analgesia was administered to the surgical area with 30 ml ofsterile saline (Izotonik Sol. 100 ml, Eczacıbaşı Baxter, Istanbul, Turkey)containing 2 mg/kg bupivacaine (Marcaine® 0.5%; AstraZeneca, Istanbul, Turkey)solution, whereas in the control group (Group II) (n=10), only 30 ml salinewas used. The solution was kept on the area for at least 5 min on a sterile gauze (Fig. 1Fig. 1.

Bottom Line: In order to examine the behavioral changes associated with acute pain, a questionnaire was prepared and given to the owners to be completed 4 hr and then 10 hr after the operation.No significant difference was found at 10 hr after the operation between the groups.In conclusion, wound infiltration with bupivacaine before incisional closure provided reliable analgesia at least 4 hr after bilateral radical mastectomy in cats.

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics and Gynaecology, Faculty of Veterinary Medicine, Istanbul University, Avcılar, 34320, Istanbul, Turkey.

ABSTRACT
The analgesic effect of wound infiltration with bupivacaine was evaluated in cats undergoing bilateral mastectomy. Twenty-one female cats with mammary gland tumors were anesthetized with propofol and oxygen-isoflurane anesthesia following premedication with atropine. In the trial group (Group I; n=11), 30 ml of saline containing 2 mg/kg of bupivacaine was infiltrated topically into the surgical wound right after removal of the mammary glands, whereas only saline solution was infiltrated in the control group (Group II; n=10). At the same time, carprofen (4 mg/kg) was also administered subcutaneously in both groups. Behavioral signs of pain were monitored during the recovery period after general anesthesia. In order to examine the behavioral changes associated with acute pain, a questionnaire was prepared and given to the owners to be completed 4 hr and then 10 hr after the operation. According to the owners' anwers to the questionnaire, a pain score was specified using a "numerical rating scale" for each cat. Although some cats showed mild to moderate pain, the pain score recorded at 4 hr after the operation was significantly lower in Group I (P<0.001). No significant difference was found at 10 hr after the operation between the groups. The incidence of vocalization, aggression and convulsion within 2 hr after the operation was also lower in Group I. In conclusion, wound infiltration with bupivacaine before incisional closure provided reliable analgesia at least 4 hr after bilateral radical mastectomy in cats.

Show MeSH
Related in: MedlinePlus