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Cancer stem cells in primary liver cancers: pathological concepts and imaging findings.

Joo I, Kim H, Lee JM - Korean J Radiol (2015)

Bottom Line: There is accumulating evidence that cancer stem cells (CSCs) play an integral role in the initiation of hepatocarcinogenesis and the maintaining of tumor growth.Liver CSCs derived from hepatic stem/progenitor cells have the potential to differentiate into either hepatocytes or cholangiocytes.Primary liver cancers originating from CSCs constitute a heterogeneous histopathologic spectrum, including hepatocellular carcinoma, combined hepatocellular-cholangiocarcinoma, and intrahepatic cholangiocarcinoma with various radiologic manifestations.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Seoul National University Hospital, Seoul 110-744, Korea.

ABSTRACT
There is accumulating evidence that cancer stem cells (CSCs) play an integral role in the initiation of hepatocarcinogenesis and the maintaining of tumor growth. Liver CSCs derived from hepatic stem/progenitor cells have the potential to differentiate into either hepatocytes or cholangiocytes. Primary liver cancers originating from CSCs constitute a heterogeneous histopathologic spectrum, including hepatocellular carcinoma, combined hepatocellular-cholangiocarcinoma, and intrahepatic cholangiocarcinoma with various radiologic manifestations. In this article, we reviewed the recent concepts of CSCs in the development of primary liver cancers, focusing on their pathological and radiological findings. Awareness of the pathological concepts and imaging findings of primary liver cancers with features of CSCs is critical for accurate diagnosis, prediction of outcome, and appropriate treatment options for patients.

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Scirrhous hepatocellular carcinoma in 50-year-old female patient with liver cirrhosis.A. Arterial phase CT image showing lobulated mass with peripheral enhancement in segment 8 of liver. B. Portal phase CT image demonstrating prolonged centripetal enhancement of tumor. C. Specimen photograph showing lobulated solid yellowish-white mass.
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Figure 10: Scirrhous hepatocellular carcinoma in 50-year-old female patient with liver cirrhosis.A. Arterial phase CT image showing lobulated mass with peripheral enhancement in segment 8 of liver. B. Portal phase CT image demonstrating prolonged centripetal enhancement of tumor. C. Specimen photograph showing lobulated solid yellowish-white mass.

Mentions: Scirrhous HCC, a subtype of HCC with significant proportions of fibrous stroma within the tumor, has been reported to account for 4.6% of all HCCs (68). However, the definition of scirrhous HCC has varied in the literature. The minimum amount of intratumoral fibrous component required ranged from 30% to 50% in various definitions (38, 68, 69, 70, 71). Morphologically, in addition to marked stromal fibrosis, these tumors are often without encapsulation and atrophy of tumor cell trabeculae (Fig. 10). There is accumulating evidence that scirrhous HCCs also express HPC markers, leading to the suggestion that scirrhous HCCs may have stem-cell traits. Small HPC-like cells are also observed at the periphery of tumor cell nests (71, 72). Scirrhous HCCs have been linked to clinicopathological features with more aggressive behavior, such as more frequent vascular invasion, more infiltrative growth, and decreased disease-free survival compared to conventional HCCs (71).


Cancer stem cells in primary liver cancers: pathological concepts and imaging findings.

Joo I, Kim H, Lee JM - Korean J Radiol (2015)

Scirrhous hepatocellular carcinoma in 50-year-old female patient with liver cirrhosis.A. Arterial phase CT image showing lobulated mass with peripheral enhancement in segment 8 of liver. B. Portal phase CT image demonstrating prolonged centripetal enhancement of tumor. C. Specimen photograph showing lobulated solid yellowish-white mass.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4296278&req=5

Figure 10: Scirrhous hepatocellular carcinoma in 50-year-old female patient with liver cirrhosis.A. Arterial phase CT image showing lobulated mass with peripheral enhancement in segment 8 of liver. B. Portal phase CT image demonstrating prolonged centripetal enhancement of tumor. C. Specimen photograph showing lobulated solid yellowish-white mass.
Mentions: Scirrhous HCC, a subtype of HCC with significant proportions of fibrous stroma within the tumor, has been reported to account for 4.6% of all HCCs (68). However, the definition of scirrhous HCC has varied in the literature. The minimum amount of intratumoral fibrous component required ranged from 30% to 50% in various definitions (38, 68, 69, 70, 71). Morphologically, in addition to marked stromal fibrosis, these tumors are often without encapsulation and atrophy of tumor cell trabeculae (Fig. 10). There is accumulating evidence that scirrhous HCCs also express HPC markers, leading to the suggestion that scirrhous HCCs may have stem-cell traits. Small HPC-like cells are also observed at the periphery of tumor cell nests (71, 72). Scirrhous HCCs have been linked to clinicopathological features with more aggressive behavior, such as more frequent vascular invasion, more infiltrative growth, and decreased disease-free survival compared to conventional HCCs (71).

Bottom Line: There is accumulating evidence that cancer stem cells (CSCs) play an integral role in the initiation of hepatocarcinogenesis and the maintaining of tumor growth.Liver CSCs derived from hepatic stem/progenitor cells have the potential to differentiate into either hepatocytes or cholangiocytes.Primary liver cancers originating from CSCs constitute a heterogeneous histopathologic spectrum, including hepatocellular carcinoma, combined hepatocellular-cholangiocarcinoma, and intrahepatic cholangiocarcinoma with various radiologic manifestations.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Seoul National University Hospital, Seoul 110-744, Korea.

ABSTRACT
There is accumulating evidence that cancer stem cells (CSCs) play an integral role in the initiation of hepatocarcinogenesis and the maintaining of tumor growth. Liver CSCs derived from hepatic stem/progenitor cells have the potential to differentiate into either hepatocytes or cholangiocytes. Primary liver cancers originating from CSCs constitute a heterogeneous histopathologic spectrum, including hepatocellular carcinoma, combined hepatocellular-cholangiocarcinoma, and intrahepatic cholangiocarcinoma with various radiologic manifestations. In this article, we reviewed the recent concepts of CSCs in the development of primary liver cancers, focusing on their pathological and radiological findings. Awareness of the pathological concepts and imaging findings of primary liver cancers with features of CSCs is critical for accurate diagnosis, prediction of outcome, and appropriate treatment options for patients.

Show MeSH
Related in: MedlinePlus