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Cancer stem cells in primary liver cancers: pathological concepts and imaging findings.

Joo I, Kim H, Lee JM - Korean J Radiol (2015)

Bottom Line: There is accumulating evidence that cancer stem cells (CSCs) play an integral role in the initiation of hepatocarcinogenesis and the maintaining of tumor growth.Liver CSCs derived from hepatic stem/progenitor cells have the potential to differentiate into either hepatocytes or cholangiocytes.Primary liver cancers originating from CSCs constitute a heterogeneous histopathologic spectrum, including hepatocellular carcinoma, combined hepatocellular-cholangiocarcinoma, and intrahepatic cholangiocarcinoma with various radiologic manifestations.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Seoul National University Hospital, Seoul 110-744, Korea.

ABSTRACT
There is accumulating evidence that cancer stem cells (CSCs) play an integral role in the initiation of hepatocarcinogenesis and the maintaining of tumor growth. Liver CSCs derived from hepatic stem/progenitor cells have the potential to differentiate into either hepatocytes or cholangiocytes. Primary liver cancers originating from CSCs constitute a heterogeneous histopathologic spectrum, including hepatocellular carcinoma, combined hepatocellular-cholangiocarcinoma, and intrahepatic cholangiocarcinoma with various radiologic manifestations. In this article, we reviewed the recent concepts of CSCs in the development of primary liver cancers, focusing on their pathological and radiological findings. Awareness of the pathological concepts and imaging findings of primary liver cancers with features of CSCs is critical for accurate diagnosis, prediction of outcome, and appropriate treatment options for patients.

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Related in: MedlinePlus

Spectrum of primary liver cancers according to cellular differentiation. CC = cholangiocarcinoma, cHCC-CC = combined hepatocellular-cholangiocarcinoma, HCC = hepatocellular carcinoma, WHO = World Health Organization
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Figure 1: Spectrum of primary liver cancers according to cellular differentiation. CC = cholangiocarcinoma, cHCC-CC = combined hepatocellular-cholangiocarcinoma, HCC = hepatocellular carcinoma, WHO = World Health Organization

Mentions: Extensive studies on HPC markers over the past decade have led to an increasing interest in the histological diversity of primary liver cancers. Now we have cumulative data on a wide spectrum of hepatic malignancies with various morphological and immunophenotypic features, a significant proportion of which seem to be related to HPCs (Fig. 1). These different primary liver cancers will be reviewed in the following in details.


Cancer stem cells in primary liver cancers: pathological concepts and imaging findings.

Joo I, Kim H, Lee JM - Korean J Radiol (2015)

Spectrum of primary liver cancers according to cellular differentiation. CC = cholangiocarcinoma, cHCC-CC = combined hepatocellular-cholangiocarcinoma, HCC = hepatocellular carcinoma, WHO = World Health Organization
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4296278&req=5

Figure 1: Spectrum of primary liver cancers according to cellular differentiation. CC = cholangiocarcinoma, cHCC-CC = combined hepatocellular-cholangiocarcinoma, HCC = hepatocellular carcinoma, WHO = World Health Organization
Mentions: Extensive studies on HPC markers over the past decade have led to an increasing interest in the histological diversity of primary liver cancers. Now we have cumulative data on a wide spectrum of hepatic malignancies with various morphological and immunophenotypic features, a significant proportion of which seem to be related to HPCs (Fig. 1). These different primary liver cancers will be reviewed in the following in details.

Bottom Line: There is accumulating evidence that cancer stem cells (CSCs) play an integral role in the initiation of hepatocarcinogenesis and the maintaining of tumor growth.Liver CSCs derived from hepatic stem/progenitor cells have the potential to differentiate into either hepatocytes or cholangiocytes.Primary liver cancers originating from CSCs constitute a heterogeneous histopathologic spectrum, including hepatocellular carcinoma, combined hepatocellular-cholangiocarcinoma, and intrahepatic cholangiocarcinoma with various radiologic manifestations.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Seoul National University Hospital, Seoul 110-744, Korea.

ABSTRACT
There is accumulating evidence that cancer stem cells (CSCs) play an integral role in the initiation of hepatocarcinogenesis and the maintaining of tumor growth. Liver CSCs derived from hepatic stem/progenitor cells have the potential to differentiate into either hepatocytes or cholangiocytes. Primary liver cancers originating from CSCs constitute a heterogeneous histopathologic spectrum, including hepatocellular carcinoma, combined hepatocellular-cholangiocarcinoma, and intrahepatic cholangiocarcinoma with various radiologic manifestations. In this article, we reviewed the recent concepts of CSCs in the development of primary liver cancers, focusing on their pathological and radiological findings. Awareness of the pathological concepts and imaging findings of primary liver cancers with features of CSCs is critical for accurate diagnosis, prediction of outcome, and appropriate treatment options for patients.

Show MeSH
Related in: MedlinePlus