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Bilateral macular edema in a patient treated with tamoxifen: a case report and review of the literature.

Zafeiropoulos P, Nanos P, Tsigkoulis E, Stefaniotou M - Case Rep Ophthalmol (2014)

Bottom Line: On examination, her best corrected visual acuity (BCVA) in her right eye was 3/10 and her BCVA in her left eye was 2/10.Tamoxifen therapy was discontinued, and the patient received 250 mg of acetazolamide three times a day for a period of 1 month.Both foveae regained their normal contour within 2 months, and her vision was restored to 10/10 BCVA 3 months later.

View Article: PubMed Central - PubMed

Affiliation: University Ophthalmology Clinic of Ioannina, Ioannina, Greece.

ABSTRACT
We present a case of a 41-year-old female patient with progressive bilateral visual loss. On examination, her best corrected visual acuity (BCVA) in her right eye was 3/10 and her BCVA in her left eye was 2/10. Fundus and optical coherence tomography examination revealed severe bilateral macular edema. She had been diagnosed with breast cancer 6 years ago and was receiving tamoxifen at a dosage of 20 mg/day ever since. Tamoxifen therapy was discontinued, and the patient received 250 mg of acetazolamide three times a day for a period of 1 month. Both foveae regained their normal contour within 2 months, and her vision was restored to 10/10 BCVA 3 months later. To our knowledge, this is the first case reported where bilateral intraretinal macular edema is the only retinal manifestation in a patient on oral tamoxifen.

No MeSH data available.


Related in: MedlinePlus

OCT. Severe bilateral intraretinal macular edema.
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Figure 1: OCT. Severe bilateral intraretinal macular edema.

Mentions: On examination, the Snellen best corrected visual acuity (BCVA) in her right eye (OD) was 3/10 and that in her left eye (OS) was 2/10. Intraocular pressure was normal and anterior segment examination was unremarkable. Fundus examination revealed severe bilateral macular edema. Optical coherence tomography (OCT) scan showed bilateral, intraretinal macular edema with a central macular thickness of 506 μm in her OD and of 469 μm in her OS, respectively (fig. 1). Fluorescein angiography showed late-phase diffuse hyperfluorescence corresponding to the edematous area in both eyes (fig. 2). A diagnosis of central serous retinopathy was excluded because fluorescein angiography revealed no leakage point from the choroid in early phases. Furthermore, no pigment epithelium detachment was detected.


Bilateral macular edema in a patient treated with tamoxifen: a case report and review of the literature.

Zafeiropoulos P, Nanos P, Tsigkoulis E, Stefaniotou M - Case Rep Ophthalmol (2014)

OCT. Severe bilateral intraretinal macular edema.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4296251&req=5

Figure 1: OCT. Severe bilateral intraretinal macular edema.
Mentions: On examination, the Snellen best corrected visual acuity (BCVA) in her right eye (OD) was 3/10 and that in her left eye (OS) was 2/10. Intraocular pressure was normal and anterior segment examination was unremarkable. Fundus examination revealed severe bilateral macular edema. Optical coherence tomography (OCT) scan showed bilateral, intraretinal macular edema with a central macular thickness of 506 μm in her OD and of 469 μm in her OS, respectively (fig. 1). Fluorescein angiography showed late-phase diffuse hyperfluorescence corresponding to the edematous area in both eyes (fig. 2). A diagnosis of central serous retinopathy was excluded because fluorescein angiography revealed no leakage point from the choroid in early phases. Furthermore, no pigment epithelium detachment was detected.

Bottom Line: On examination, her best corrected visual acuity (BCVA) in her right eye was 3/10 and her BCVA in her left eye was 2/10.Tamoxifen therapy was discontinued, and the patient received 250 mg of acetazolamide three times a day for a period of 1 month.Both foveae regained their normal contour within 2 months, and her vision was restored to 10/10 BCVA 3 months later.

View Article: PubMed Central - PubMed

Affiliation: University Ophthalmology Clinic of Ioannina, Ioannina, Greece.

ABSTRACT
We present a case of a 41-year-old female patient with progressive bilateral visual loss. On examination, her best corrected visual acuity (BCVA) in her right eye was 3/10 and her BCVA in her left eye was 2/10. Fundus and optical coherence tomography examination revealed severe bilateral macular edema. She had been diagnosed with breast cancer 6 years ago and was receiving tamoxifen at a dosage of 20 mg/day ever since. Tamoxifen therapy was discontinued, and the patient received 250 mg of acetazolamide three times a day for a period of 1 month. Both foveae regained their normal contour within 2 months, and her vision was restored to 10/10 BCVA 3 months later. To our knowledge, this is the first case reported where bilateral intraretinal macular edema is the only retinal manifestation in a patient on oral tamoxifen.

No MeSH data available.


Related in: MedlinePlus