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Conjunctival follicular lymphoma after treatment for invasive squamous cell carcinoma.

da Cunha LP, Barros JN, Motono M, Costa FD, da Cunha MC, Chojniak MM - Case Rep Ophthalmol (2014)

Bottom Line: The authors describe the case of a 79-year-old Caucasian woman who presented an ocular adnexal lesion as the first clinical manifestation of a systemic follicular lymphoma, highlighting the clinicopathological features of this rare entity and its potential to be misdiagnosed as marginal zone lymphoma of the mucosa-associated lymphoid tissue.After the initial presentation and diagnosis, she was submitted to complete clinical evaluation; confluent retroperitoneal lymphadenopathy was detected through abdominal computed tomography, characterizing clinical stage III.Awareness of this lymphoma is important when making a diagnosis of ocular adnexal lymphoid neoplasms for its appropriate evaluation and management.

View Article: PubMed Central - PubMed

Affiliation: Clínica de Olhos Dr. Moacir Cunha, Brazil.

ABSTRACT

Backgrounds/aims: The authors describe the case of a 79-year-old Caucasian woman who presented an ocular adnexal lesion as the first clinical manifestation of a systemic follicular lymphoma, highlighting the clinicopathological features of this rare entity and its potential to be misdiagnosed as marginal zone lymphoma of the mucosa-associated lymphoid tissue.

Methods: Conjunctival impression cytology was performed for a rapid initial diagnosis of lymphoma, and subsequent histopathological and immunohistochemical studies were carried out for its confirmation and to identify the best therapeutic regimen.

Results: After the initial presentation and diagnosis, she was submitted to complete clinical evaluation; confluent retroperitoneal lymphadenopathy was detected through abdominal computed tomography, characterizing clinical stage III.

Conclusion: Awareness of this lymphoma is important when making a diagnosis of ocular adnexal lymphoid neoplasms for its appropriate evaluation and management.

No MeSH data available.


Related in: MedlinePlus

An impression cytology demonstrating an abrupt transition from the adjacent normal bulbar conjunctiva with goblet cells (E) and a fairly monomorphic population of lymphoid cells (L), almost equal to or slightly larger than a mature lymphocyte, with a scanty cytoplasm, predominantly condensed chromatin and inconspicuous nucleoli over the lesion surface (HE. Original magnification. ×200).
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Figure 2: An impression cytology demonstrating an abrupt transition from the adjacent normal bulbar conjunctiva with goblet cells (E) and a fairly monomorphic population of lymphoid cells (L), almost equal to or slightly larger than a mature lymphocyte, with a scanty cytoplasm, predominantly condensed chromatin and inconspicuous nucleoli over the lesion surface (HE. Original magnification. ×200).

Mentions: IC samples (fig. 2) revealed an abrupt transition from the adjacent normal bulbar conjunctiva and a fairly monomorphic population of cells resembling lymphocytes, almost equal to or slightly larger than a mature lymphocyte, with scant cytoplasm, predominantly condensed chromatin and inconspicuous nucleoli over the lesion surface. Based on the cytomorphological findings, a hypothesis of a lymphoma was made and a differential diagnosis of lymphoid hyperplasia was considered [3].


Conjunctival follicular lymphoma after treatment for invasive squamous cell carcinoma.

da Cunha LP, Barros JN, Motono M, Costa FD, da Cunha MC, Chojniak MM - Case Rep Ophthalmol (2014)

An impression cytology demonstrating an abrupt transition from the adjacent normal bulbar conjunctiva with goblet cells (E) and a fairly monomorphic population of lymphoid cells (L), almost equal to or slightly larger than a mature lymphocyte, with a scanty cytoplasm, predominantly condensed chromatin and inconspicuous nucleoli over the lesion surface (HE. Original magnification. ×200).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4296246&req=5

Figure 2: An impression cytology demonstrating an abrupt transition from the adjacent normal bulbar conjunctiva with goblet cells (E) and a fairly monomorphic population of lymphoid cells (L), almost equal to or slightly larger than a mature lymphocyte, with a scanty cytoplasm, predominantly condensed chromatin and inconspicuous nucleoli over the lesion surface (HE. Original magnification. ×200).
Mentions: IC samples (fig. 2) revealed an abrupt transition from the adjacent normal bulbar conjunctiva and a fairly monomorphic population of cells resembling lymphocytes, almost equal to or slightly larger than a mature lymphocyte, with scant cytoplasm, predominantly condensed chromatin and inconspicuous nucleoli over the lesion surface. Based on the cytomorphological findings, a hypothesis of a lymphoma was made and a differential diagnosis of lymphoid hyperplasia was considered [3].

Bottom Line: The authors describe the case of a 79-year-old Caucasian woman who presented an ocular adnexal lesion as the first clinical manifestation of a systemic follicular lymphoma, highlighting the clinicopathological features of this rare entity and its potential to be misdiagnosed as marginal zone lymphoma of the mucosa-associated lymphoid tissue.After the initial presentation and diagnosis, she was submitted to complete clinical evaluation; confluent retroperitoneal lymphadenopathy was detected through abdominal computed tomography, characterizing clinical stage III.Awareness of this lymphoma is important when making a diagnosis of ocular adnexal lymphoid neoplasms for its appropriate evaluation and management.

View Article: PubMed Central - PubMed

Affiliation: Clínica de Olhos Dr. Moacir Cunha, Brazil.

ABSTRACT

Backgrounds/aims: The authors describe the case of a 79-year-old Caucasian woman who presented an ocular adnexal lesion as the first clinical manifestation of a systemic follicular lymphoma, highlighting the clinicopathological features of this rare entity and its potential to be misdiagnosed as marginal zone lymphoma of the mucosa-associated lymphoid tissue.

Methods: Conjunctival impression cytology was performed for a rapid initial diagnosis of lymphoma, and subsequent histopathological and immunohistochemical studies were carried out for its confirmation and to identify the best therapeutic regimen.

Results: After the initial presentation and diagnosis, she was submitted to complete clinical evaluation; confluent retroperitoneal lymphadenopathy was detected through abdominal computed tomography, characterizing clinical stage III.

Conclusion: Awareness of this lymphoma is important when making a diagnosis of ocular adnexal lymphoid neoplasms for its appropriate evaluation and management.

No MeSH data available.


Related in: MedlinePlus