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Botulinum toxin therapy in congenital blepharospasm.

Wabbels B - Case Rep Ophthalmol (2014)

Bottom Line: Pregnancy and delivery had been normal.A neuropediatric examination did not reveal useful findings.Four days later, clearly visible bilateral eye opening and commencement of eye contact were observed.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, University of Bonn, Bonn, Germany.

ABSTRACT
Botulinum toxin injections are the treatment of choice for the management of essential blepharospasm in adults. No cases of congenital blepharospasm have been described in the literature so far, and no cases of botulinum toxin injection in an infant have been reported. A 4-week-old girl was referred to our department with absent eye opening and spasmodically closed eyes. Pregnancy and delivery had been normal. A neuropediatric examination did not reveal useful findings. A periorbital injection of botulinum toxin was performed at the age of 2 months to prevent deprivation amblyopia. Four days later, clearly visible bilateral eye opening and commencement of eye contact were observed. At the age of 3 years, her eyelids remain open and no side effects of botulinum toxin therapy have occurred.

No MeSH data available.


Related in: MedlinePlus

a Status during the day at 3 weeks of age (picture taken by parents). b Typical findings during examination at 7 weeks of age. c Four days after injection of botulinum toxin at 2 months of age. d Picture of the girl at 3 years of age (after a single botulinum toxin injection at the age of 2 months).
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Figure 1: a Status during the day at 3 weeks of age (picture taken by parents). b Typical findings during examination at 7 weeks of age. c Four days after injection of botulinum toxin at 2 months of age. d Picture of the girl at 3 years of age (after a single botulinum toxin injection at the age of 2 months).

Mentions: A 4-week-old girl was referred to our department because of absence of eye opening. Since her birth, her eyes had been swollen and mainly spasmodically closed. Only briefly and more in the evening, slit-like eye opening occurred for a maximum of 1 h (fig. 1a). Then, the child turned her face towards light sources. The morphologic assessment was hampered by massive blepharospasm (fig. 1b). The child reacted with eyes closed to direct flashlight in the dark, e.g., by turning away or grimacing. Immediate massive blepharospasm was present even when lid opening was attempted in her sleep or following administration of local anesthetic eyedrops.


Botulinum toxin therapy in congenital blepharospasm.

Wabbels B - Case Rep Ophthalmol (2014)

a Status during the day at 3 weeks of age (picture taken by parents). b Typical findings during examination at 7 weeks of age. c Four days after injection of botulinum toxin at 2 months of age. d Picture of the girl at 3 years of age (after a single botulinum toxin injection at the age of 2 months).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4296243&req=5

Figure 1: a Status during the day at 3 weeks of age (picture taken by parents). b Typical findings during examination at 7 weeks of age. c Four days after injection of botulinum toxin at 2 months of age. d Picture of the girl at 3 years of age (after a single botulinum toxin injection at the age of 2 months).
Mentions: A 4-week-old girl was referred to our department because of absence of eye opening. Since her birth, her eyes had been swollen and mainly spasmodically closed. Only briefly and more in the evening, slit-like eye opening occurred for a maximum of 1 h (fig. 1a). Then, the child turned her face towards light sources. The morphologic assessment was hampered by massive blepharospasm (fig. 1b). The child reacted with eyes closed to direct flashlight in the dark, e.g., by turning away or grimacing. Immediate massive blepharospasm was present even when lid opening was attempted in her sleep or following administration of local anesthetic eyedrops.

Bottom Line: Pregnancy and delivery had been normal.A neuropediatric examination did not reveal useful findings.Four days later, clearly visible bilateral eye opening and commencement of eye contact were observed.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, University of Bonn, Bonn, Germany.

ABSTRACT
Botulinum toxin injections are the treatment of choice for the management of essential blepharospasm in adults. No cases of congenital blepharospasm have been described in the literature so far, and no cases of botulinum toxin injection in an infant have been reported. A 4-week-old girl was referred to our department with absent eye opening and spasmodically closed eyes. Pregnancy and delivery had been normal. A neuropediatric examination did not reveal useful findings. A periorbital injection of botulinum toxin was performed at the age of 2 months to prevent deprivation amblyopia. Four days later, clearly visible bilateral eye opening and commencement of eye contact were observed. At the age of 3 years, her eyelids remain open and no side effects of botulinum toxin therapy have occurred.

No MeSH data available.


Related in: MedlinePlus