Maternal body mass index in early pregnancy and offspring asthma, rhinitis and eczema up to 16 years of age.
Bottom Line: In contrast, no significant associations were found for rhinitis, eczema or sensitization.Maternal BMI is associated with an increased risk of asthma, but not rhinitis, eczema or sensitization; however, overweight in the offspring seems to have a mediating role.Prevention strategies of maternal pre-pregnancy and childhood obesity might be important to reduce the prevalence of childhood asthma.
Affiliation: Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.Show MeSH
Related in: MedlinePlus
Mentions: Figure1 shows the associations between maternal BMI in early pregnancy and prevalent and incident asthma, rhinitis, eczema and sensitization to inhalant allergens with maternal BMI treated as a continuous variable and underweight mothers excluded (n = 117, leaving 3177 children in the analyses). Maternal BMI was associated with an increased overall risk (using GEE) of asthma in the offspring (adj OR per 5 kg/m2 increase, e.g. BMI 25 kg/m2 compared with 20 kg/m2: 1.23; 95% CI 1.07–1.40 for prevalent asthma and 1.17; 95% CI 1.03–1.32 for incident asthma). No statistically significant associations were found for the association between maternal BMI and rhinitis, eczema or sensitization (adj OR: 1.07; 95% CI 0.96–1.19 for prevalent rhinitis, 1.03; 95% CI 0.93–1.14 for prevalent eczema and 1.05; 95% CI 0.93–1.19 for prevalent sensitization). No significant interactions were found between maternal BMI and gender or parental history of allergic disease. Additional adjustments for potential mediators (birth weight, mode of delivery, breastfeeding and newborn respiratory diagnosis) had no major influence on the observed ORs (data not shown) and were not included in the subsequent analyses.
Affiliation: Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.