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Salivary duct carcinoma with rhabdoid features: report of 2 cases with immunohistochemical and ultrastructural analyses.

Kusafuka K, Onitsuka T, Muramatsu K, Miki T, Murai C, Suda T, Fuke T, Kamijo T, Iida Y, Nakajima T - Head Neck (2013)

Bottom Line: This submandibular tumor was also composed of both residual pleomorphic adenoma region and invasive adenocarcinoma components, whereas some metastatic lesions were purely composed of rhabdoid cells.Such cells were strongly and diffusely positive for cytokeratins (CKs), gross cystic disease fluid protein-15 (GCDFP), and androgen receptor (AR).Case 1 was also positive for Her-2 and p53.

View Article: PubMed Central - PubMed

Affiliation: Pathology Division, Shizuoka Cancer Center, Shizuoka, Japan.

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Ultrastructural finding of case 1. The condensation of the intermediated filaments and dilated segments of rough endoplasm reticulum were frequently observed in tumor cell cytoplasm. Scale bar = 1 μm.
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fig06: Ultrastructural finding of case 1. The condensation of the intermediated filaments and dilated segments of rough endoplasm reticulum were frequently observed in tumor cell cytoplasm. Scale bar = 1 μm.

Mentions: By electron microscope, tumor cells were variably sized, ovoid, or cuboidal. Tumor cells contained the condensation of intermediate filaments, dilated segments of rough endoplasmic reticulum, and mitochondria (Figure 6). Tumor cells frequently lacked the adherence junction and tight junction. The nuclei of tumor cells frequently showed irregular shapes with dense nuclear membranes.


Salivary duct carcinoma with rhabdoid features: report of 2 cases with immunohistochemical and ultrastructural analyses.

Kusafuka K, Onitsuka T, Muramatsu K, Miki T, Murai C, Suda T, Fuke T, Kamijo T, Iida Y, Nakajima T - Head Neck (2013)

Ultrastructural finding of case 1. The condensation of the intermediated filaments and dilated segments of rough endoplasm reticulum were frequently observed in tumor cell cytoplasm. Scale bar = 1 μm.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4296234&req=5

fig06: Ultrastructural finding of case 1. The condensation of the intermediated filaments and dilated segments of rough endoplasm reticulum were frequently observed in tumor cell cytoplasm. Scale bar = 1 μm.
Mentions: By electron microscope, tumor cells were variably sized, ovoid, or cuboidal. Tumor cells contained the condensation of intermediate filaments, dilated segments of rough endoplasmic reticulum, and mitochondria (Figure 6). Tumor cells frequently lacked the adherence junction and tight junction. The nuclei of tumor cells frequently showed irregular shapes with dense nuclear membranes.

Bottom Line: This submandibular tumor was also composed of both residual pleomorphic adenoma region and invasive adenocarcinoma components, whereas some metastatic lesions were purely composed of rhabdoid cells.Such cells were strongly and diffusely positive for cytokeratins (CKs), gross cystic disease fluid protein-15 (GCDFP), and androgen receptor (AR).Case 1 was also positive for Her-2 and p53.

View Article: PubMed Central - PubMed

Affiliation: Pathology Division, Shizuoka Cancer Center, Shizuoka, Japan.

Show MeSH
Related in: MedlinePlus