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Salivary duct carcinoma with rhabdoid features: report of 2 cases with immunohistochemical and ultrastructural analyses.

Kusafuka K, Onitsuka T, Muramatsu K, Miki T, Murai C, Suda T, Fuke T, Kamijo T, Iida Y, Nakajima T - Head Neck (2013)

Bottom Line: This submandibular tumor was also composed of both residual pleomorphic adenoma region and invasive adenocarcinoma components, whereas some metastatic lesions were purely composed of rhabdoid cells.Such cells were strongly and diffusely positive for cytokeratins (CKs), gross cystic disease fluid protein-15 (GCDFP), and androgen receptor (AR).Case 1 was also positive for Her-2 and p53.

View Article: PubMed Central - PubMed

Affiliation: Pathology Division, Shizuoka Cancer Center, Shizuoka, Japan.

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Immunohistochemical results for rhabdoid cells in both cases. Rhabdoid cells were positive for pan-cytokeratin (CK) (A: case 2: immunostaining: original magnification ×200), gross cystic disease fluid protein-15 (GCDFP-15). (B: case 1: immunostaining ×200) androgen receptor (AR) (C: case 2: immunostaining: original magnification ×200). They were positive for Her-2 (D: immunostaining: original magnification ×200) and p53 (E: immunostaining: original magnification ×200) in case 1. They were also diffusely positive for Ki-67 in case 2 (F: immunostaining: original magnification ×200).
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fig04: Immunohistochemical results for rhabdoid cells in both cases. Rhabdoid cells were positive for pan-cytokeratin (CK) (A: case 2: immunostaining: original magnification ×200), gross cystic disease fluid protein-15 (GCDFP-15). (B: case 1: immunostaining ×200) androgen receptor (AR) (C: case 2: immunostaining: original magnification ×200). They were positive for Her-2 (D: immunostaining: original magnification ×200) and p53 (E: immunostaining: original magnification ×200) in case 1. They were also diffusely positive for Ki-67 in case 2 (F: immunostaining: original magnification ×200).

Mentions: In both cases, rhabdoid cells showed diffuse positivity for pan-cytokeratin (CK), CK7, epithelial membrane antigen (EMA), gross cystic disease fluid protein (GCDFP)-15, and androgen receptor (AR; Figure 4A–4C). Moreover, such cells in case 1 were positive for Her-2, prostate-specific antigen (PSA), and p53 (Figure 4D and 4E). Although the primary carcinoma in case 2 was negative for GCDFP-15, AR, Her-2, and PSA, both this component and the rhabdoid component were strongly positive for p16.


Salivary duct carcinoma with rhabdoid features: report of 2 cases with immunohistochemical and ultrastructural analyses.

Kusafuka K, Onitsuka T, Muramatsu K, Miki T, Murai C, Suda T, Fuke T, Kamijo T, Iida Y, Nakajima T - Head Neck (2013)

Immunohistochemical results for rhabdoid cells in both cases. Rhabdoid cells were positive for pan-cytokeratin (CK) (A: case 2: immunostaining: original magnification ×200), gross cystic disease fluid protein-15 (GCDFP-15). (B: case 1: immunostaining ×200) androgen receptor (AR) (C: case 2: immunostaining: original magnification ×200). They were positive for Her-2 (D: immunostaining: original magnification ×200) and p53 (E: immunostaining: original magnification ×200) in case 1. They were also diffusely positive for Ki-67 in case 2 (F: immunostaining: original magnification ×200).
© Copyright Policy - open-access
Related In: Results  -  Collection

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Show All Figures
getmorefigures.php?uid=PMC4296234&req=5

fig04: Immunohistochemical results for rhabdoid cells in both cases. Rhabdoid cells were positive for pan-cytokeratin (CK) (A: case 2: immunostaining: original magnification ×200), gross cystic disease fluid protein-15 (GCDFP-15). (B: case 1: immunostaining ×200) androgen receptor (AR) (C: case 2: immunostaining: original magnification ×200). They were positive for Her-2 (D: immunostaining: original magnification ×200) and p53 (E: immunostaining: original magnification ×200) in case 1. They were also diffusely positive for Ki-67 in case 2 (F: immunostaining: original magnification ×200).
Mentions: In both cases, rhabdoid cells showed diffuse positivity for pan-cytokeratin (CK), CK7, epithelial membrane antigen (EMA), gross cystic disease fluid protein (GCDFP)-15, and androgen receptor (AR; Figure 4A–4C). Moreover, such cells in case 1 were positive for Her-2, prostate-specific antigen (PSA), and p53 (Figure 4D and 4E). Although the primary carcinoma in case 2 was negative for GCDFP-15, AR, Her-2, and PSA, both this component and the rhabdoid component were strongly positive for p16.

Bottom Line: This submandibular tumor was also composed of both residual pleomorphic adenoma region and invasive adenocarcinoma components, whereas some metastatic lesions were purely composed of rhabdoid cells.Such cells were strongly and diffusely positive for cytokeratins (CKs), gross cystic disease fluid protein-15 (GCDFP), and androgen receptor (AR).Case 1 was also positive for Her-2 and p53.

View Article: PubMed Central - PubMed

Affiliation: Pathology Division, Shizuoka Cancer Center, Shizuoka, Japan.

Show MeSH
Related in: MedlinePlus